- Studies on expression of DNA topoisomerases genes and protooncogene c-Myc during hepatocarcinogenesis
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Hwang BD, Won SH, Kwon KR, Kim KY, Kang DY, Kwak ST, Lim K
- KMID: 1694362
- J Korean Cancer Assoc.
- 1993 Oct;25(5):636-650.
No abstract available. -
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- Expression of DNA Topoisomerase II and P-Glycoprotein in Breast Cancer
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Park HR, Jung EH, Sohn JH, Park YE
- KMID: 2175461
- J Korean Cancer Assoc.
- 1997 Apr;29(2):242-249.
PURPOSE: To determine whether the expression of DNA topoisomerase II and P-glycoprotein are of prognostic value. MATERIALS AND METHODS: We evaluated the expression of DNA topoisomerase II and P-glycoprotein immunohistochemically... -
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- Localization of DNA Topoisomerase II on High Salt Extract Chromatin Fraction of Mouse Embry Fibroblast Cells Treated with Bezo(a)pyrene and Doxorubicin
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Lee DG, Kim JG, Jung IC, Cho MY
- KMID: 2260972
- Korean J Obstet Gynecol.
- 1998 May;41(5):1437-1445.
This study was conducted to determine if there exists a DNA topoisomerase II participating in the cleave and rejoining of DNA in the nuclear fraction of a mouse embryo fibroblast,... -
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- Altered Expression of DNA Topoisomerase IIalpha, Ki-67, p53 and p27 in Non-Hodgkin's Lymphoma
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Lee KM, Sol MY, Kang HJ, Shin DH, Choi KU, Kim HW, Kim JY, Park DY, Lee CH
- KMID: 1598234
- Korean J Pathol.
- 2005 Oct;39(5):332-337.
BACKGROUND: Topoisomerase II (TOPO II) is an enzyme that separates intertwined chromosomes during DNA synthesis by transiently breaking and joining DNA strands. The level of TOP II is one of... -
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- Construction of Painting probe for Chromosome Band 18p11.1-p11.2
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Seo YS, Chun YH, Park SY, Kim H, Park SH
- KMID: 1937885
- Korean J Anat.
- 1998 Oct;31(5):753-760.
Chromosome microdissection has become a very powerful approach to generate chromosome band-specific library and painting probes for physical mapping or cytogenetic analysis. Here we have constructed the band-specific painting probe... -
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- Multidrug Resistance-Related Gene Expressions in Germ Cell Tumors in Testis
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Lee JW, Lee SC, Kim WJ
- KMID: 2290041
- Korean J Urol.
- 1996 Apr;37(4):392-400.
The development of drug resistance is a major obstacle in effective cancer chemotherapy. Multidrug resistance(MDR) is a widely studied phenomenon of interest to both clinicians and research workers because many... -
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- Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
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Kim IS, Lee NY, Kim S, Ki CS, Kim SH
- KMID: 1106455
- Yonsei Med J.
- 2011 Jan;52(1):188-191.
- doi: 10.3349/ymj.2011.52.1.188
Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs > or = 0.5 microg/mL). These six isolates had no significant quinolone... -
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- Irinotecan (CPT-11)-induced hemorrhagic colitis
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Kim JH, Choi MH, Ryu JH, Jang HJ, Eun CS, Kae SH, Lee J
- KMID: 2306090
- Korean J Med.
- 2002 Dec;63(6):688-691.
Irinotecan (CPT-11) is a chemotherapeutic agent that inhibits topoisomerase I and has shown efficacy against advanced colorectal cancer. Diarrhea is the most common toxicity that has been reported to be... -
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- Construction and Application of Painting Probe for Chromosome Band 1p36.1, 7q11, 7q32-34, 17q12-21
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Kim KH, Park SY, Jeon YH, Park SH
- KMID: 2075422
- Korean J Obstet Gynecol.
- 1998 Feb;41(2):433-440.
Chromosome microdissection has become a very powerful approach to generate chromosome band-specific library and painting probes for physical mapping or cytogenetic analysis. Here we have constructed the band-specific painting probes... -
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- A Case of Typhlitis Developed after Chemotherapy with Irinotecan and Cisplatin in a Patient with Small Cell Lung Carcinoma
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Ji EH, Kim YM, Kim SJ, Yeom SJ, Ha SE, Kang HH, Kang JY, Lee SH, Moon HS
- KMID: 2050683
- Tuberc Respir Dis.
- 2012 Nov;73(5):288-291.
- doi: 10.4046/trd.2012.73.5.288
Typhlitis is a necrotizing colitis that usually occurs in neutropenic patients and develops most often in patients with hematologic malignancies such as leukemia and lymphoma. Typhlitis may proceed to bowel... -
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- Camptothecin-nduced Apoptosis in Gastric Cancer Cell Lines: Involvement of Bcl-
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Cha YJ, Min YD, Choi CH
- KMID: 1940174
- J Korean Surg Soc.
- 1998 Dec;55(6):800-808.
BACKGROUND: Apoptosis can be induced by various anticancer agents. Resistance to apoptosis may play an important role in tumors refractory to chemotherapy. The authors investigated both the induction of apoptosis... -
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- Role of ATF on Transcriptional Regulation of DNA Topoisomerase II a Gene in HL - 60 Arrested to G2 / M and M Phase
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Lim K, Son MY, Choi BI, Yun KA, Zheng M, Kang TW, Lee YC, Park JI, Yoon WH, Hwang BD
- KMID: 2175140
- J Korean Cancer Assoc.
- 1999 Dec;31(6):1279-1287.
PURPOSE: To gain insight on transcriptional repression of Topo II a in HL-60 cells arrested to G2/M and M phase, the levels of Topo IIa mRNA and the binding activity... -
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- The Immunohistochemical Expression of DNA Topoisomerase II-alpha and E2F-1 in the Breast Carcinoma and Their Relationship with Clinicopathologic Factors
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Kim HY, Lim HM, Lee TJ, Park SJ, Cha SJ, Kim BG
- KMID: 2096039
- J Korean Surg Soc.
- 2003 Feb;64(2):93-100.
PURPOSE: Clinical courses of breast cancer are very different, and concern for finding a predictable marker of breast carcinomas has increased. This study focused on the relationship between the expressions... -
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- The Immunohistochemical Expression of E2F-1 Protein and DNA Topoisomerase II-alpha E2F-1 Protein in Colorectal Cancer and Their Relationship with Clinicopathologic Factors
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Hwang SI, Lee TJ, Park YG, Ji GC, Lee JH, Chang IT, Park SI
- KMID: 2004546
- J Korean Surg Soc.
- 2003 Jul;65(1):35-41.
PURPOSE: E2F-1 is a transcriptor that converts G1 to S in the cell cycle, and Topoisomerase II-alpha is a key enzyme in the metabolism of DNA, and an indicator of... -
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- Construction and Analysis of Painting Probe for Homogeneously Staining Regions in Human Neuroblastoma Cell line IMR-32
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Park SH, Kim HC, Chun YH
- KMID: 1963064
- J Genet Med.
- 1997 Sep;1(1):45-50.
Painting probe for HSRs in IMR-32 Neuroblastoma, a pediatric malignant neoplasm of neural crest origin, has a wide range of clinical virulence. The mechanisms contributing to the development of neuroblastomas... -
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- The Expression of Bcl-2, Bax, Cytochrome C and Caspase-3 in Camptothecin-Induced Apoptosis of Mouse 3T3 Fibroblasts
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Ahn YJ, Lee MS, Kang G
- KMID: 2073723
- Korean J Pathol.
- 2002 Apr;36(2):71-76.
BACKGROUND: Camptothecin (CPT), which has been used for cancer treatment and apoptosis as an inhibitor of DNA topoisomerase I. We investigated the possibility that camptothecin induces anti-appoptotic bcl-2 and pro-apoptotic... -
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- Anti-epidermal growth factor receptor (EGFR) monoclonal antibody and DNA topoisomerase inhibitor reduce growth of salivary adenoid cystic carcinoma in a murine model
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Park YW, Lee HS
- KMID: 2189945
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Jun;36(3):177-185.
- doi: 10.5125/jkaoms.2010.36.3.177
INTRODUCTION: Epidermal growth factor receptor (EGFR) is expressed in human epithelial tumors including salivary cancers, and known to be correlated with tumor progression and poor clinical courses in some epithelial... -
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- Expression of c-erbB-2 Oncoprotein and DNA Topoisomerase II-alpha in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix
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Shin SH, Koo HM, Kim JS, Mun HK, Lee JD, Kim SY, Han JH, Cho TI, Lee TJ
- KMID: 2270617
- Korean J Obstet Gynecol.
- 2002 Dec;45(12):2124-2129.
OBJECTIVE: The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix. METHODS: Total 81 formalin-fixed,... -
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- Expression of DNA Topoisomerase II-alpha as a Proliferating Marker in Urothelial Carcinoma of Urinary Bladder based on World Health Organization/International Society of Urological Pathology Consensus Classification: A Correlation with Expression of Ki-67 and Apoptosis
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Lee TJ, Lee DK, Park ES, Yoo JH
- KMID: 2275562
- Korean J Pathol.
- 2002 Oct;36(5):305-313.
BACKGROUND: DNA topoisomerase II-alpha is linked with active cell proliferation in mammalian cells. The aim of this study was to examine the relationship between the expression of DNA topoisomerase II-alpha... -
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- Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90
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Jun KY, Kwon Y
- KMID: 2351668
- Biomol Ther.
- 2016 Sep;24(5):453-468.
- doi: 10.4062/biomolther.2016.168
There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The... -
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