Korean J Obstet Gynecol.  2002 Dec;45(12):2124-2129.

Expression of c-erbB-2 Oncoprotein and DNA Topoisomerase II-alpha in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix

• Shin SH
• Koo HM
• Kim JS
• Mun HK
• Lee JD
• Kim SY
• Han JH
• Cho TI
• Lee TJ

Abstract

OBJECTIVE
The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix.
METHODS
Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha.
RESULTS
The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha.
CONCLUSION
There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.

Keyword

c-erbB-2; topoisomerase II-alpha; uterine cervix; precancerous lesion; invasive squamous cell carcinoma

MeSH Terms

Carcinoma, Squamous Cell*
Cervix Uteri*
DNA Topoisomerases, Type I*
DNA*
Female
Immunohistochemistry
Receptor, erbB-2
DNA
DNA Topoisomerases, Type I
Receptor, erbB-2