Korean J Obstet Gynecol.
2003 Oct;46(10):1905-1911.
Expression of p63 and p53 Proteins in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix
- Affiliations
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- 1Department of Obstetrics and Gynecology, Seoul Sung Ae General Hospital, Seoul, Korea.
- 2Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.
Abstract
OBJECTIVE
p63 is a member of the p53 gene family. The main aim of this study was to compare p63 and p53 expression in precancerous lesions and invasive squamous cell carcinoma of the uterine cervix.
METHODS
Total 81 formalin-fixed, paraffin-embedded sections of low-grade squamous intraepithelial lesion (22 cases), high-grade squamous intraepithelial lesion (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of p63, p53 and topoisomerase II-alpha.
RESULTS
p63 was statistically significant higher immunoreactivity according to progression of uterine cervical squamous lesions, but p53 was not significant. No statistical correlation was found between p63 and p53. Topoisomerase II-alpha index was statistically significant higher according to increase of p63 expression.
CONCLUSION
These findings suggest that the expression of p63 protein may play a roles in progression and proliferative activities of the uterine cervical squamous lesions.
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