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Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH

P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult...
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p40 Immunohistochemistry Is an Excellent Marker in Primary Lung Squamous Cell Carcinoma

Affandi KA, Tizen NM, Mustangin , Zin RR

BACKGROUND: Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma...
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Expression of p63 and its association with cell proliferation at different stages of murine hair follicle cycle

Lee BW, Oh JW, Seo M, Hwang JS, Yoon B

In the present study, we investigated the expression patterns of p63, a member of the p53 gene family, in hair follicle cells at different stages of the hair cycle and...
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Immunohistochemical evaluation of p63 and cyclin D1 in oral squamous cell carcinoma and leukoplakia

Patel SB, Manjunatha BS, Shah V, Soni N, Sutariya R

OBJECTIVES: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63...
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Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-beta1/beta2, and p63 in Sebaceous and Follicular Tumors

Jeon SY, Kim DC, Song KH, Kim KH

BACKGROUND: Certain epidermal appendage tumors, including hyperplasias (hamartomas), adenomas, benign epitheliomas, primordial epitheliomas, and malignant tumors, can exhibit any stage of differentiation. Several molecules associated with tumorigenesis, such as Gli-1,...
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The prognostic significance of p16, Ki-67, p63, and CK17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia 1

Kim SM, Lee JU, Lee DW, Kim MJ, Lee HN

OBJECTIVE: To evaluate the prognostic significance of p16, Ki-67, p63, and cytokeratin (CK) 17 expression determined by immunohistochemical staining in cervical intraepithelial neoplasia (CIN) 1. METHODS: Biopsy tissue samples from 33...
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Distinction of Pulmonary Large Cell Neuroendocrine Carcinoma from Small Cell Lung Carcinoma Using a Panel of Bcl-2, p63, and 34betaE12

Li JZ, Choi C, Choi YD, Na KJ

BACKGROUND: Making the distinction between large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) is difficult in some samples of biopsy tissues, but we have to separate LCNEC...
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Expression of p63 and its Isoform, deltaNp63, in Non-Small Cell Lung Carcinoma

Kim ID, Shin DH, Choi KU, Park DY, Huh GY, Sol MY, Lee MK, Kim YD, Lee CH

  • KMID: 2459591
  • Korean J Pathol.
  • 2009 Aug;43(4):321-328.
BACKGROUND: Several studies have been conducted on the role of the p63 gene family in non-small cell lung carcinoma (NSCLC). Nevertheless, the role of these genes in the development and...
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Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss

Kang H, Lee YJ, Park YM, Kim SY, Kim HO, Lee SD

  • KMID: 2302103
  • Korean J Dermatol.
  • 2008 Feb;46(2):181-188.
BACKGROUND: Integrins have a crucial function in the attachment of cells to the extracellular matrix and as important transducers of signals from the extracellular matrix to the matrix cells of...
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Efficient Cultivation Conditions for Human Limbal Epithelial Cells

Kim MK, Lee JL, Oh JY, Shin MS, Shin KS, Wee WR, Lee JH, Park KS, Son YS

To compare the stem niche in different culture conditions of limbal epithelial cells, the suspended human limbal epithelial cells (HLECs) were seeded on the 3T3-pretreated plates and the other suspended...
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Impaired Delta NP63 Expression is Associated with Poor Tumor Development in Transitional Cell Carcinoma of the Bladder

He Y, Wu X, Tang W, Tian D, Luo C, Yin Z, Du H

The oncogenic isoform of the p63 protein, delta NP63, plays an important role in the pathogenesis of many epithelial carcinomas, and emerging evidences suggest that delta NP63 is a promising...
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Expression of dominant negative p63 isoform in well-differenciated oral squamous cell carcinoma

Kim IS, Kim CH, Kim KW

  • KMID: 2190264
  • J Korean Assoc Oral Maxillofac Surg.
  • 2007 Jun;33(3):191-198.
The p53 which is well known as tumor suppressor gene is located at 17p13. p53 is a sequence-specific DNA binding transcription factor that responds to certain cytotoxic stresses, such as...
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The expression of Ki-67, p63, p53, and p27 as a biological marker for grading cervical intraepithelial neoplasia and cervical carcinoma

Kim YJ, Lee HJ, Kim SH, Park MH, Cho SH

  • KMID: 2273115
  • Korean J Obstet Gynecol.
  • 2007 Apr;50(4):629-637.
OBJECTIVE: To determine the pattern of expression of p63, p27, and p53 as well as Ki-67 and its efficacy to discriminate the cervical lesion such as intraepithelial lesion, microinvasive carcinoma,...
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Expression of p63 in Various Hyperproliferative Skin Diseases

Han SS, Chang SE, Jung HJ, Lee MW, Choi JH, Moon KC, Koh JK

The keratinocytes in human epidermis are replaced by a population of stem cells located in the basal layer of the epidermis and one candidate stem cell marker is the transcription...
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The Clinicopathologic Significance of a p63 Expression in Invasive Breast Cancer

Lee SR, Cho JS, Hong KD, Ryu WS, Lee JB, Son GS, Bae JW, Kim AR, Koo BH

  • KMID: 1844898
  • J Korean Surg Soc.
  • 2006 Oct;71(4):243-249.
PURPOSE: p63 is a recently described as p53 homologue. Despite their structural homologies, they have different activities. p63 is a specific myoepithelial cell marker in normal breast tissue and it...
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The relationship of p63 expression with cell proliferation and apoptosis in DMBA-induced hamster buccal pouch carcinogenesis

Park JH, Lee WD, Min CG, Kang JH, Myung H, Lee JH, Kim MJ

  • KMID: 2190389
  • J Korean Assoc Oral Maxillofac Surg.
  • 2005 Jun;31(3):219-227.
PURPOSE: Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family,...
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Expression of p63,bcl-2,bcl-6 and p16 in Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin

Zheng Z, Kye Y, Zhang X, Kim A, Kim I

  • KMID: 2275425
  • Korean J Pathol.
  • 2005 Apr;39(2):91-98.
BACKGROUND: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the common malignant neoplasms of the skin. The p63 is a p53 homologue which is considered to be a...
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Expression of p63 in Reactive Hyperplasias and Malignant Lymphomas

Park CK, Oh YH

p63 is a recently described p53 homologue. It is involved in survival and differentiation of reserve/stem cells in epithelia. To obtain new insights into the role of p63 in malignant...
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p63 and p73 in Tumor Suppression and Promotion

McKeon FD

  • KMID: 1807301
  • Cancer Res Treat.
  • 2004 Feb;36(1):6-12.
The recent discovery of two genes, termed p63 and p73, encoding transcription factors highly homologous to p53 presents unexpected challenges and opportunities for the understanding and treatment of cancers. The...
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Analysis of Expression of p63 in Cervical Neoplasia Comparing with Other Immunohistochemical Markers

Kim MY, Cho SH, Park MH

  • KMID: 2275537
  • Korean J Pathol.
  • 2003 Oct;37(5):333-341.
BACKGROUND: The reproducibility in grading a cervical intraepithelial neoplasia (CIN) are not perfect. The aim of this study was to assess the value of the immunohistochemical expression of p63 and...
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