- A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models
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Heo JR, Hwang KA, Kim SU, Choi KC
- KMID: 2464425
- Cancer Res Treat.
- 2019 Apr;51(2):797-811.
- doi: 10.4143/crt.2018.364
PURPOSE: In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line (HB1.F3) was transduced into... -
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- Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node–Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models
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Park GT, Kim SU, Choi KC
- KMID: 2367506
- Cancer Res Treat.
- 2017 Jan;49(1):79-91.
- doi: 10.4143/crt.2015.503
PURPOSE: Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, genetically engineered human neural stem cells... -
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- Selective Delivery of a Therapeutic Gene for Treatment of Head and Neck Squamous Cell Carcinoma Using Human Neural Stem Cells
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Kwon SK, Kim SU, Song JJ, Cho CG, Park SW
- KMID: 2468440
- Clin Exp Otorhinolaryngol.
- 2013 Sep;6(3):176-183.
OBJECTIVES: Based on studies of the extensive tropism of neural stem cells (NSCs) toward malignant brain tumor, we hypothesized that NSCs could also target head and neck squamous cell carcinoma... -
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- Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells
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Park JS, Chang DY, Kim JH, Jung JH, Park J, Kim SH, Lee YD, Kim SS, Suh-Kim H
- KMID: 2154229
- Exp Mol Med.
- 2013 Feb;45(2):e10.
Human mesenchymal stem cells (MSCs) have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases; this is, in part, because they have the capability... -
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- Tumor targeted gene therapy
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Kang JH
- KMID: 1512522
- Nucl Med Mol Imaging.
- 2006 Oct;40(5):237-242.
Knowledge of molecular mechanisms governing malignant transformation brings new opportunities for therapeutic intervention against cancer using novel approaches. One of them is gene therapy based on the transfer of genetic... -
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- The Transfection of Cytosine Deaminase Gene and the Cell Killing Effects of Administration of 5-Fluorocytosine in Colon Cancer Cell Lines
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Cha SW, Chang SK
- KMID: 1896294
- J Korean Surg Soc.
- 2004 Apr;66(4):271-280.
PURPOSE: Among cancer gene therapies, the aims to eliminate malignant cells using genes as drugs as substitutes for conventional therapy, the use of bacterial cytosine deaminase (CD) which can convert... -
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- Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine
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Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY
- KMID: 755664
- Exp Mol Med.
- 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine... -
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- Suicide Gene Therapy for Bladder Cancer Using a Recombinant Adenovirus Expressing Escherichia Coli Cytosine Deaminase
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Ahn M, Lim HY, Kao C, Gardner TA, Ko SC, Kim SJ
- KMID: 1990951
- Korean J Urol.
- 2003 Mar;44(3):244-249.
PURPOSE: The poor prognosis of advanced bladder cancer requires the investigation of novel treatment modalities. In this study, we investigated the suicide gene therapy for bladder cancer, using the adenovirus-mediated... -
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- Adenovirus-Mediated Toxic Gene Therapy Using Cytosine Deaminase and Osteocalcin Promoter for the Treatment of Prostate Cancer
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Park HS, Bae JH, Moon DG, Cho HY, Kao C, Gardner TA, Cheon J
- KMID: 1583951
- Korean J Urol.
- 2000 Dec;41(12):1437-1444.
No abstract available. -
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- Enhancement of Bystander Prostate Cancer Cell Killing by the Utilization of Bone Marrow Stromal Cells Genetically Engineered to Express Cytosine Deaminase
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Kim SJ, Gardner TA, Ko SC, Kao C, Chung LW
- KMID: 1583473
- Korean J Urol.
- 2000 Aug;41(8):933-939.
No abstract available. -
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