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Elevated Levels of T Helper 17 Cells Are Associated with Disease Activity in Patients with Rheumatoid Arthritis

Kim J, Kang S, Kim J, Kwon G, Koo S

BACKGROUND: Interleukin-17 (IL-17)-producing T helper (Th) 17 cells are considered as a new subset of cells critical to the development of rheumatoid arthritis (RA). We aimed to investigate the distribution...
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Activation of monocytes, T-lymphocytes and plasma inflammatory markers in angina patients

Lee WH, Lee Y, Kim JR, Chu JA, Lee SY, Jung JO, Kim JS, Kim S, Seo JD, Rhee SS, Park JE

  • KMID: 755045
  • Exp Mol Med.
  • 1999 Sep;31(3):159-164.
Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the plasma levels of inflammatory markers and the degree of activation of peripheral blood monocytes and T-lymphocytes...
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Novel Mutations in the UNC13D Gene Carried by a Chinese Neonate with Hemophagocytic Lymphohistiocytosis

Chen Y, Wang Z, Cheng Y, Tang Y

Hemophagocytic lymphohistiocytosis (HLH) in different ethnicities has been described in the literature, but few cases in patients of Chinese descent have been reported. Here, we describe the case of a...
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The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis

Jung S, Park YK, Shin JH, Lee H, Kim SY, Lee GR, Park SH

TGF-beta-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved...
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Letter to the Editor: Acute Effects of Intravenous Administration of Pamidronate in Patients with Osteoporosis

Marcuzzi A, Zanin V, Vuch J, Pontillo A, Crovella S

No abstract available.
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Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism

Lee SH, Kim EJ, Lee DH, Lee WY, Chung BC, Seo HS, Choi MH

BACKGROUND: Eicosanoids are metabolites of arachidonic acid that are rapidly biosynthesized and degraded during inflammation, and their metabolic changes reveal altered enzyme expression following drug treatment. We developed an eicosanoid...
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Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model

Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G

In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its...
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Chemopreventive and metabolic effects of inulin on colon cancer development

Hijova E, Szabadosova V, Stofilova , Hrckova G

Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4...
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Therapeutic effects of recombinant Salmonella typhimurium harboring CCL22 miRNA on atopic dermatitis-like skin in mice

Yoon WS, Lee SS, Chae YS, Park YK

Th-2-biased immune responses are known to play a key role in the pathogenesis of atopic dermatitis. In particular, the macrophage-derived chemokine CCL22 is directly implicated in Th-2-associated skin inflammatory reactions,...
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Immunomodulatory effects of betulinic acid from the bark of white birch on mice

Yi JE, Obminska-Mrukowicz B, Yuan LY, Yuan H

The objective of this study was to explore the immunomodulatory effects of betulinic acid (BA) extracted from the bark of white birch on mice. Female mice were orally administered BA...
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