- CYP3A5*3 Polymorphism and Its Clinical Implications and Pharmacokinetic Role
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Park JY, Cha YJ, Kim KA
- KMID: 2317850
- Transl Clin Pharmacol.
- 2014 Jun;22(1):3-7.
The cytochrome P450 (CYP) 3A subfamily is estimated to participate in the biotransformation of 50% of the currently prescribed drugs. Four members of the CYP3A subfamily have been identified in... -
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- Population Pharmacokinetics of Midazolam in Healthy Koreans: Effect of Cytochrome P450 3A-mediated Drug-drug Interaction
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Shin KH
- KMID: 2369008
- Korean J Clin Pharm.
- 2016 Dec;26(4):312-317.
- doi: 10.0000/kjcp.2016.26.4.312
OBJECTIVE: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop... -
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- Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats
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Noh K, Nepal MR, Jeong KS, Kim SA, Um YJ, Seo CS, Kang MJ, Park PH, Kang W, Jeong HG, Jeong TC
- KMID: 2380355
- Biomol Ther.
- 2015 Mar;23(2):201-206.
- doi: 10.4062/biomolther.2014.134
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the... -
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- Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes
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Han KM, Ahn SY, Seo H, Yun J, Cha HJ, Shin JS, Kim YH, Kim H, Park HK, Lee YM
- KMID: 2378807
- Biomol Ther.
- 2017 May;25(3):288-295.
- doi: 10.4062/biomolther.2016.153
The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and... -
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- Comparative evaluation of phenobarbital-induced CYP3A and CYP2H1 gene expression by quantitative RT-PCR in Bantam, Bantamized White Leghorn and White Leghorn chicks
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Goriya HV, Kalia A, Bhavsar SK, Joshi CG, Rank DN, Thaker AM
- KMID: 1090760
- J Vet Sci.
- 2005 Dec;6(4):279-285.
The present work was to study induction of cytochrome P450 (CYP)3A and CYP2H1 gene by reverse transcriptase polymerase chain reaction (RT-PCR) and quantitative RTPCR in Bantam, Bantamized White Leghorn and... -
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- Assessment of Hepatic Cytochrome P450 3A Activity Using Metabolic Markers in Patients with Renal Impairment
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Kim AH, Yoon S, Lee Y, Lee J, Bae E, Lee H, Kim DK, Lee S, Yu KS, Jang IJ, Cho JY
- KMID: 2429888
- J Korean Med Sci.
- 2018 Dec;33(53):e298.
- doi: 10.3346/jkms.2018.33.e298
BACKGROUND: The renal function of individuals is one of the reasons for the variations in therapeutic response to various drugs. Patients with renal impairment are often exposed to drug toxicity,... -
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- Dosage Adjustment before and after Warfarin - Rifampin Combination Therapy
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Kim DH, Kim KH, Choi KH, Lee KJ, Lee HS, Son IJ, Kim KB, Lee JW, Ahn H
- KMID: 2140190
- Korean J Thorac Cardiovasc Surg.
- 2008 Jun;41(3):354-359.
BACKGROUND: Warfarin is used as an anticoagulant and it is mainly excreted by the liver metabolism (the R-form is mainly metabolized by cytochrome p450 3A4, and the S form by... -
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- Functional Comparison of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells as Sources of Hepatocyte-Like Cells
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Jeong J, Kim KN, Chung MS, Kim HJ
- KMID: 2360886
- Tissue Eng Regen Med.
- 2016 Dec;13(6):740-749.
- doi: 10.1007/s13770-016-0094-y
Pluripotent stem cells can differentiate into many cell types including mature hepatocytes, and can be used in the development of new drugs, treatment of diseases, and in basic research. In... -
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- An NH(2)-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells
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Jeon S, Kim KH, Yun CH, Hong BW, Chang YS, Han HS, Yoon YS, Choi WB, Kim S, Lee AY
- KMID: 1052948
- Exp Mol Med.
- 2008 Apr;40(2):254-260.
- doi: 10.3858/emm.2008.40.2.254
Cytochrome P450 3A4 (CYP3A4), is the dominant human liver hemoprotein enzyme localized in the endoplasmic reticulum (ER), and is responsible for the metabolism of more than 50% of clinically relevant... -
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- Development and validation of a HPLC-UV method for 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in humans: providing in vivo evidence of CYP3A4-mediated CPHP formation
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Park JY, Shin JG
- KMID: 2351802
- Transl Clin Pharmacol.
- 2016 Sep;24(3):147-151.
- doi: 10.12793/tcp.2016.24.3.147
We developed a high-performance liquid chromatographic procedure for the determination of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a toxic metabolite of haloperidol, in human. Chromatographic analysis was performed on a reverse-phase Câ‚₈ column with... -
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- Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis
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Okabayashi S, Kobayashi , Saito E, Toyonaga T, Ozaki R, Sagami S, Nakano M, Tanaka J, Yagisawa K, Kuronuma S, Takeuchi O, Hibi T
- KMID: 2449963
- Intest Res.
- 2019 Apr;17(2):218-226.
- doi: 10.5217/ir.2018.00117
BACKGROUND/AIMS: The pharmacokinetics of tacrolimus (TAC) is known to be largely influenced by single-nucleotide polymorphisms (SNPs) in CYP3A5. Patients starting TAC require careful dose adjustment, owing to the wide range... -
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- Effect of Atorvastatin and Clopidogrel Co-Administration After Coronary Stenting in Korean Patients With Stable Angina
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Kim GB, Kim JK, Park S, Jeong JJ, Yoon HS, Ko SH, Ko JE, Park SJ, Nam SW, Lee JH, Hyon MS
- KMID: 2225151
- Korean Circ J.
- 2011 Jan;41(1):28-33.
- doi: 10.4070/kcj.2011.41.1.28
BACKGROUND AND OBJECTIVES: It was reported that atorvastatin co-administered with clopidogrel for 8 months did not affect the anti-platelet potency of clopidogrel in Korean patients with acute coronary syndrome, but... -
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- Meta-Analysis of First-Line Triple Therapy for Helicobacter pylori Eradication in Korea: Is It Time to Change?
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Gong EJ, Yun SC, Jung HY, Lim H, Choi KS, Ahn JY, Lee JH, Kim DH, Choi KD, Song HJ, Lee GH, Kim JH
- KMID: 1786114
- J Korean Med Sci.
- 2014 May;29(5):704-713.
- doi: 10.3346/jkms.2014.29.5.704
Proton pump inhibitor (PPI)-based triple therapy consisting of PPI, amoxicillin, and clarithromycin, is the recommended first-line treatment for Helicobacter pylori infection. However, the eradication rate of triple therapy has declined... -
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- Influencing Factors for Cure of Clonorchiasis by Praziquantel Therapy: Infection Burden and CYP3A5 Gene Polymorphism
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Kim CH, Lee JK, Chung BS, Li S, Choi MH, Hong ST
- KMID: 1715632
- Korean J Parasitol.
- 2011 Mar;49(1):45-49.
- doi: 10.3347/kjp.2011.49.1.45
Chemotherapy of clonorchiasis with praziquantel (PZQ) is effective but about 15% of treated cases have been reported uncured. The present study investigated correlation of single nucleotide polymorphisms (SNPs) of the... -
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