- Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells
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Mutoh H, Sashikawa , Sakamoto H, Tateno T
- KMID: 2070061
- Gut Liver.
- 2014 Sep;8(5):508-518.
- doi: 10.5009/gnl13237
BACKGROUND/AIMS: Doublecortin and CaM kinase-like-1 (DCAMKL1) is a marker of stem cells expressed predominantly in the crypt base in the intestine. However, DCAMKL1-positive cells have been shown to be differentiated... -
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- Cyclooxygenase-2 Expression Is Related to the Epithelial-to-Mesenchymal Transition in Human Colon Cancers
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Jang TJ, Jeon KH, Jung KH
- KMID: 1777097
- Yonsei Med J.
- 2009 Dec;50(6):818-824.
- doi: 10.3349/ymj.2009.50.6.818
PURPOSE: Down-regulation of E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT). EMT progression in cancer cells is associated with the loss of certain epithelial markers and the acquisition of... -
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- Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway
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Shin S, Joo SS, Park D, Jeon JH, Kim TK, Kim JS, Park SK, Hwang BY, Kim YB
- KMID: 1106156
- J Vet Sci.
- 2010 Mar;11(1):43-50.
- doi: 10.4142/jvs.2010.11.1.43
The anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG) were investigated in vitro and in vivo using croton oil-induced inflammation models. Croton oil (20 microgram/mL) up-regulated mRNA expression... -
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- Chemopreventive and metabolic effects of inulin on colon cancer development
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Hijova E, Szabadosova V, Stofilova , Hrckova G
- KMID: 1712304
- J Vet Sci.
- 2013 Dec;14(4):387-393.
- doi: 10.4142/jvs.2013.14.4.387
Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4... -
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- Leukotriene-related Gene Polymorphisms in Patients with Aspirin-intolerant Urticaria and Aspirin-intolerant Asthma: Differing Contributions of ALOX5 Polymorphism in Korean Population
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Kim SH, Choi JH, Holloway J, Suh CH, Nahm DH, Ha EH, Park CS, Park HS
- KMID: 2157738
- J Korean Med Sci.
- 2005 Dec;20(6):926-931.
- doi: 10.3346/jkms.2005.20.6.926
The pathogenesis of aspirin (acetylsalicylic acid, ASA)-intolerant urticaria (AIU) is still poorly understood but it has recently been suggested that it is associated with the overproduction of leukotriene (LT). This... -
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- AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin
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Lee YK, Park SY, Kim YM, Lee WS, Park OJ
- KMID: 1123467
- Exp Mol Med.
- 2009 Mar;41(3):201-207.
- doi: 10.3858/emm.2009.41.3.023
AMPK (AMP-activated protein kinase) is highly conserved in eukaryotes, where it functions primarily as a sensor of cellular energy status. Recent studies indicate that AMPK activation strongly suppresses cell proliferation... -
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- beta-irradiation (166Ho patch)-induced skin injury in mini-pigs: effects on NF-kappaB and COX-2 expression in the skin
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Kim JS, Rhim KJ, Jang WS, Lee SJ, Son Y, Lee SS, Park S, Lim SM
- KMID: 2160814
- J Vet Sci.
- 2015 Mar;16(1):1-9.
- doi: 10.4142/jvs.2015.16.1.1
In the present study, the detrimental effect of beta-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing the animals to 50 and 100 Gy of... -
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- Effect of Pertussis Toxin and Herbimycin A on Proteinase-Activated Receptor 2-Mediated Cyclooxygenase 2 Expression in Helicobacter pylori-Infected Gastric Epithelial AGS Cells
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Seo JH, Seo JY, Chung HY, Kim H
- KMID: 1777026
- Yonsei Med J.
- 2011 May;52(3):522-526.
- doi: 10.3349/ymj.2011.52.3.522
Helicobacter pylori (H. pylori) is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Proteinase-activated receptor 2 (PAR2), subgroup of G-protein coupled receptor family, is highly expressed... -
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- Probiotics may Reduce Inflammation by Enhancing Peroxisome Proliferator Activated Receptor gamma Activation in HT-29 Cells
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Eun CS, Han DS, Lee SH, Jeon YC, Sohn JH, Kim YS, Lee J
- KMID: 782835
- Korean J Gastroenterol.
- 2007 Mar;49(3):139-146.
BACKGROUND/AIMS: The peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor highly expressed in the colon which plays an anti-inflammatory role through the inhibition of nuclear factor-kappaB (NF-kappaB) pathway. Probiotics... -
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- Endoplasmic reticulum stress (ER-stress) by 2-deoxy-D-glucose (2DG) reduces cyclooxygenase-2 (COX-2) expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes
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Yu SM, Kim SJ
- KMID: 994401
- Exp Mol Med.
- 2010 Nov;42(11):777-786.
- doi: 10.3858/emm.2010.42.11.079
Endoplasmic reticulum (ER) stress regulates a wide range of cellular responses including apoptosis, proliferation, inflammation, and differentiation in mammalian cells. In this study, we observed the role of 2-deoxy-D-glucose (2DG)... -
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