- Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis
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Wang J, Guo X, Zhang J, Song J, Ji M, Yu S, Wang J, Cao Z, Dong W
- KMID: 1798130
- Yonsei Med J.
- 2013 Nov;54(6):1353-1361.
- doi: 10.3349/ymj.2013.54.6.1353
PURPOSE: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective... -
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- The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study
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Huang J, Zhang D, Xie F, Lin D
- KMID: 2164533
- J Vet Sci.
- 2015 Jun;16(2):225-231.
- doi: 10.4142/jvs.2015.16.2.225
Increasing evidence suggests that cancer stem cells (CSCs) are responsible for tumor initiation and maintenance. Additionally, it is becoming apparent that cyclooxygenase (COX) signaling is associated with canine mammary tumor... -
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- Cox-2 and IL-10 Polymorphisms and Association with Squamous Cell Carcinoma of The Head and Neck in a Korean Sample
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Jeong SW, Tae K, Lee SH, Kim KR, Park CW, Park BL, Shin HD
- KMID: 1792951
- J Korean Med Sci.
- 2010 Jul;25(7):1024-1028.
- doi: 10.3346/jkms.2010.25.7.1024
Cyclooxygenase-2 (COX-2) is involved in inflammation and carcinogenesis. Interleukin-10 (IL-10) is also regarded as anti-inflammatory factors with the multi-functional ability to positively and negatively influence functional immunity and tumor development.... -
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- Evidence for Cyclooxygenase-2 Association with Caveolin-3 in Primary Cultured Rat Chondrocytes
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Kwak JO, Lee WK, Kim HW, Jung SM, Oh KJ, Jung SY, Huh YH, Cha SH
- KMID: 2157791
- J Korean Med Sci.
- 2006 Feb;21(1):100-106.
- doi: 10.3346/jkms.2006.21.1.100
The purpose of this study was to demonstrate the cellular localization of cyclooxygenase-2 (COX-2) and caveolin-3 (Cav-3) in primarily cultured rat chondrocytes. In normal rat chondrocytes, we observed relatively high... -
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- Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells
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Lee JA, Song HY, Ju SM, Lee SJ, Kwon HJ, Eum WS, Jang SH, Choi SY, Park J
- KMID: 756206
- Exp Mol Med.
- 2009 Sep;41(9):629-637.
- doi: 10.3858/emm.2009.41.9.069
Inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) have been known to be involved in various pathophysiological processes such as inflammation. This study was performed to determine the regulatory... -
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- Comparison of pharmacological and genetic inhibition of cyclooxygenase-2: effects on adult neurogenesis in the hippocampal dentate gyrus
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Nam SM, Kim JW, Yoo DY, Choi JH, Kim W, Jung HY, Won MH, Hwang IK, Seong JK, Yoon YS
- KMID: 2344296
- J Vet Sci.
- 2015 Sep;16(3):245-251.
- doi: 10.4142/jvs.2015.16.3.245
Inducible cyclooxygenase-2 (COX-2) has received much attention because of its role in neuro-inflammation and synaptic plasticity. Even though COX-2 levels are high in healthy animals, the function of this factor... -
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- Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells
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Park EJ, Kwon TK
- KMID: 1058704
- Exp Mol Med.
- 2011 Dec;43(12):669-675.
- doi: 10.3858/emm.2011.43.12.077
Cyclooxygenase-2 (COX-2) is an important enzyme in inflammation. In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231... -
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