J Korean Med Sci.  2010 Jul;25(7):1024-1028. 10.3346/jkms.2010.25.7.1024.

Cox-2 and IL-10 Polymorphisms and Association with Squamous Cell Carcinoma of The Head and Neck in a Korean Sample

• Jeong SW
• Tae K
• Lee SH
• Kim KR
• Park CW
• Park BL
• Shin HD

• KMID: 1792951
• DOI: http://doi.org/10.3346/jkms.2010.25.7.1024

Abstract

Cyclooxygenase-2 (COX-2) is involved in inflammation and carcinogenesis. Interleukin-10 (IL-10) is also regarded as anti-inflammatory factors with the multi-functional ability to positively and negatively influence functional immunity and tumor development. Genetic polymorphisms of COX-2 and IL-10 might contribute to the development of squamous cell carcinoma of the head and neck (SCCHN). The purpose of this study was to evaluate the association of COX-2 and IL-10 single nucleotide polymorphisms (SNPs) with the risk of SCCHN in a Korean sample. We analyzed the COX-2 SNPs, -1329A>G, +1266C>T, and +6365T>C, and the IL-10 SNPs, -1082A>G, +920T>G, and +3917T>C, in 290 Korean SCCHN patients and 358 healthy controls. There was no significant association between the risk of SCCHN and the three COX-2 or three IL-10 SNPs. We analyzed three haplotypes (ht1, ht2, ht3) for COX-2 and found that COX-2 ht3+/+ was associated with a decreased risk of SCCHN in a Korean sample, compared with the COX-2 ht3 -/- genotype (P=0.03). Two haplotypes (ht1, ht2) of IL-10 were analyzed and there was no statistical significance in the distribution of haplotypes. Based on these results, the COX-2 haplotype ht3 can be used as a molecular biomarker to predict low risk groups of SCCHN in a Korean sample.

Keyword

Carcinom, Squamous Cell; Head and Neck Neoplasms; Cyclooxygenase 2; Interleukin-10; Polymorphism, Genetic; Polymorphism, Single Nucleotide

MeSH Terms

Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group/*genetics
Carcinoma, Squamous Cell/*genetics
Cyclooxygenase 2/*genetics
Female
*Genetic Predisposition to Disease
Genotype
Haplotypes
Head and Neck Neoplasms/*genetics
Humans
Interleukin-10/*genetics
Korea
Male
Middle Aged
*Polymorphism, Genetic
Risk Factors

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