- Expression of Cyclin A, B1, D1, D3, and E in Non-Small Lung Cancers
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Ha SY, Kim HK, Im JS, Cho HY, Chung DH, An J
- KMID: 2199874
- J Lung Cancer.
- 2012 Jun;11(1):33-37.
- doi: 10.6058/jlc.2012.11.1.33
PURPOSE: Cyclins, and their associated cyclin dependent kinases, regulate progression of the cell cycle through the G1 phase and into the S-phase during the DNA replication process. Cyclin E regulation... -
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- Cyclin B1 and D1 expression in invasive cervical cancer
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Kim YT, Zhao M, Kim HY, Kang MH, Kim JW, Kim SH, Kim JH, Kim SW, Yoon BS
- KMID: 1575056
- Korean J Gynecol Oncol.
- 2005 Sep;16(3):256-263.
OBJECTIVE: Cyclin is a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases (CDKs),... -
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- CHANGES OF CYCLINS, CYCLIN DEPENDENT KINASES, CYCLIN DEPENDENT KINASE INHIBITORS DURING GLOSSAL DEVELOPMENT IN THE RATS
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Kim HH, Lee SC
- KMID: 2005912
- J Korean Assoc Oral Maxillofac Surg.
- 1997 Nov;23(4):581-596.
The molecular mechanisms that regulate glossal muscle cell cycle and terminal differentiation remain largely unknown. To determine which cyclins, cyclin dependent kinases (CDKs), cyclin dependent kinase inhibitors (CKIs) are important... -
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- Changes in expression of cell cycle regulators and their hepatic lobular distribution in partial hepatectomy-induced regenerating rat liver
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Jeong JS, Lee JH, Kim HI, Park JI
- KMID: 646039
- J Korean Med Sci.
- 1999 Dec;14(6):635-642.
- doi: 10.3346/jkms.1999.14.6.635
Partial hepatectomy (PH) endorses quiescent hepatocytes to reenter the cell cycle. The regenerating liver returns to its preresection weight after 7 days, following one or two cell division and maintains... -
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- The function of p27(KIP1) during tumor development
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Lee J, Kim SS
- KMID: 1122277
- Exp Mol Med.
- 2009 Nov;41(11):765-771.
- doi: 10.3858/emm.2009.41.11.102
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which... -
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- Tannic acid-induced apoptosis in FaDu hypopharyngeal squamous cell carcinoma
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Ta LT, Nguyen TT, Yoo H
- KMID: 2452746
- Int J Oral Biol.
- 2019 Jun;44(2):43-49.
- doi: 10.11620/IJOB.2019.44.2.43
Tannic acid (TA) is a water-soluble polyphenol compound found in various herbal plants. We investigated the chemopreventive effects of TA on FaDu hypopharyngeal squamous carcinoma cells. In an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide... -
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- Human Papillomavirus Infection and Expression of Cyclin D1 in the Uterine Cervical Neoplasia
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Kim MK, Kim HB, Lee SK, Sunwoo JG, Bae DH, Kim CJ
- KMID: 2143478
- Korean J Gynecol Oncol Colposc.
- 2002 Mar;13(1):28-37.
About 80 subtypes of human papilloma viruses(HPVs) were known, and they were divided into two groups as 'high-risk HPVs' and 'low-risk HPVs' according to their oncogenic potentialities. Even though the... -
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- The Clinical Significance of p21 Expressionin Gastric Adenocarcinoma
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Kim SJ, Son GS
- KMID: 2206344
- J Korean Surg Soc.
- 1998 Jul;55(1):65-69.
BACKGROUNDS: The p21 protein inhibits cyclin-dependent kinases and mediates cell-cycle arrest and cell differentiation. METHODS: This study was performed in 61 patients with gastric adenocarcinoma to investigate the realtionship between... -
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- Expression of p21WAF1/CIP1/SDI1 in Epithelial Ovarian Cancer ; Its Relationship with p53 Expression and Prognostic Factors
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Kim BS, Lee SK, Lee JH, Kim SB
- KMID: 2261174
- Korean J Obstet Gynecol.
- 1998 Sep;41(9):2447-2453.
The p21WAF1/CIP1/SDI1 protein is a potent inhibitor of cyclin dependent kinases. The tumor growth suppressor WAF1/CIP1/SDI1 was shown to be induced not only by p53 but also by other mechanisms.... -
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- Cell cycle regulators during human atrial development
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Kim WH, Joo CU, Ku JH, Ryu CH, Koh KN, Koh GY, Ko JK
- KMID: 759076
- Korean J Intern Med.
- 1998 Jul;13(2):77-82.
OBJECTIVES: The molecular mechanisms that regulate cardiomyocyte cell cycle and terminal differentiation in humans remain largely unknown. To determine which cyclins, cyclin dependent kinases (CDKs) and cyclin kinase inhibitors (CKIs)... -
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- Biochemical characterizations reveal different properties between CDK4/cyclin D1 and CDK2/cyclin A
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Kim DM, Yang K, Yang BS
- KMID: 1093615
- Exp Mol Med.
- 2003 Oct;35(5):421-430.
CDK2 and CDK4 known promoter of cell cycling catalyze phosphorylation of RB protein. Enzyme specificity between two CDKs that work at a different cell cycle phase is not clearly understood.... -
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- Expressions of Cyclin E-pathway Proteins (cyclinE, cdk2, p21, p27, p57) and Their Prognostic Significance in Non-small Cell Lung Carcinomas
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Jung JH, Park G, Lee MA, Byun JH, Jung CK, Lee H, Lee KY, Shim SI, Kang CS
- KMID: 1593157
- Korean J Pathol.
- 2006 Feb;40(1):24-31.
BACKGROUND: The aberrant expression of cyclins, cdk and cdk inhibitor has been shown to be involved in oncogenic transformation. The aim of this study was to investigate the expression of... -
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- Expression of p27Kip1 Protein Associated with Poor Clinical Outcome in Human Gastric Cancer
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Bu DS, Han SH, Bae BN, Kim KH, Kim HJ, Kim YD, Kim HY, Park KM
- KMID: 1895841
- J Korean Surg Soc.
- 2001 Aug;61(2):153-157.
PURPOSE: p27Kip1 protein is an inhibitor of cyclin-dependent kinases and is thought to be a potential prognostic indicator for numerous human cancers. We investigated the expression of p27Kip1 in gastric... -
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- Expression of p34(cdc2), p27(Kip1), p21(WAF1/Cip1) and p53 in Human Breast Cancers
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Kim DH, Park CK, Lee HJ, Lee WM, Kim EK, Joo JE
- KMID: 2073753
- Korean J Pathol.
- 2005 Dec;39(6):391-400.
BACKGROUND: Cell cycle progression is governed by cell cycle regulators and inhibitors such as the cyclin dependent kinases (CDK), p27(Kip1), p21(WAF1/Cip1) and p53. The purpose of this study was... -
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- Dysregulation of Cell Cycle Regulating Proteins in Peripheral Lymphocytes from the Patients with Alzheimer's Disease
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Chung SH, Kwon YA, Kim H, Shin JY, Kim DK
- KMID: 2286986
- Korean J Psychopharmacol.
- 2004 Dec;15(4):474-479.
OBJECTIVE: Extensive neuronal death occurring in the Alzheimer's disease (AD) may be related with the apoptosis. Recent studies have suggested that regulatory failure of cell cycle appeared to be very... -
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- The Effects of p21 on Bladder Cancers
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Jung W, Cho IC, Ha YS, Jo SH, Park MS, Lee YS, Yoon SJ, Kim WJ
- KMID: 2294271
- Korean J Urol.
- 2006 Nov;47(11):1149-1154.
- doi: 10.4111/kju.2006.47.11.1149
Purpose: p21 protein is an inhibitor of cyclin-dependent kinases, which may be able to arrest the cell cycle at the G1 phase by inhibiting DNA replication through the interaction with... -
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- Expressions of Cell Cycle Control Genes in Human Uterine Cervical Cancer Cells
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Ahn JG, Lee TS, Cho JW, Baek WK, Suh SI, Suh MH, Park JW, Cha SD
- KMID: 2137118
- J Korean Cancer Assoc.
- 2000 Feb;32(1):110-119.
PURPOSE: Recently, many aspects of biological functions of cyclins, cyclin-dependent kinases (CDKs), CDK inhibitors and Rb gene have been reported, and the cell cycle control genes are considered to act important roles in... -
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- The role of p21/CIP1/WAF1 (p21) in the negative regulation of the growth hormone/growth hormone receptor and epidermal growth factor/epidermal growth factor receptor pathways, in growth hormone transduction defect
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Kostopoulou E, Rojas Gil , Spiliotis
- KMID: 2432278
- Ann Pediatr Endocrinol Metab.
- 2018 Dec;23(4):204-209.
- doi: 10.6065/apem.2018.23.4.204
PURPOSE: Growth hormone transduction defect (GHTD) is characterized by severe short stature, impaired STAT3 (signal transducer and activator of transcription-3) phosphorylation and overexpression of the cytokine inducible SH2 containing protein... -
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- Impact of methylation of the p16INK4a gene on the prognosis ofhead and neck squamous cell carcinoma patients
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Lee EH, Hwang DS, Shin SH, Kim UK, Chung IK, Kim YD
- KMID: 2189706
- J Korean Assoc Oral Maxillofac Surg.
- 2012 Apr;38(2):101-109.
- doi: 10.5125/jkaoms.2012.38.2.101
OBJECTIVES: The inactivation of the tumor suppressor gene p16INK4a plays an important role in the development of malignant tumors, including oral squamous cell carcinoma. The p16 gene is involved in... -
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- The effects of gamma-radiation on cyclin-dependent kinases and their inhibitors in cultured vascular smooth muscle cells
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Zo JH
- KMID: 2029537
- Korean Circ J.
- 2001 Jan;31(1):63-73.
- doi: 10.4070/kcj.2001.31.1.63
BACKGROUND: In spite of the clinical introduction of brachytherapy to reduce restenosis, the biologic responses of vascular smooth muscle cells(VSMCs) to radiation have not been well studied. We investigated the... -
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