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Significant results: statistical or clinical?

Park S

The null hypothesis significance test method is popular in biological and medical research. Many researchers have used this method for their research without exact knowledge, though it has both merits...
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Alternatives to P value: confidence interval and effect size

Lee DK

The previous articles of the Statistical Round in the Korean Journal of Anesthesiology posed a strong enquiry on the issue of null hypothesis significance testing (NHST). P values lie at...
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Clinical Application of Overlapping Confidence Intervals for Monitoring Changes in Serial Clinical Chemistry Test Results

Cho J, Seo DM, Uh Y

BACKGROUND: Interpretation of changes in serial laboratory results is necessary for both clinicians and laboratories; however, setting decision limits is not easy. Although the reference change value (RCV) has been...
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Statistical Data Editing in Scientific Articles

Habibzadeh F

Scientific journals are important scholarly forums for sharing research findings. Editors have important roles in safeguarding standards of scientific publication and should be familiar with correct presentation of results, among...
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Comparison of Parametric and Bootstrap Method in Bioequivalence Test

Ahn BJ, Yim DS

The estimation of 90% parametric confidence intervals (CIs) of mean AUC and Cmax ratios in bioequivalence (BE) tests are based upon the assumption that formulation effects in log-transformed data are...
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Test-Retest Reliability of a Questionnaire for the Korea Youth Risk Behavior Web-Based Survey

Bae J, Joung H, Kim JY, Kwon KN, Kim YT, Park SW

OBJECTIVES: A web-based survey has been administered annually since 2005 throughout Korea to assess the prevalence of adolescent health risk behaviors among middle and high school students. The aim of...
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Biochemical Analysis on Postmortem Specimens

Chung NE, Choi YS, Lee HY

  • KMID: 1849206
  • Korean J Leg Med.
  • 2000 Oct;24(2):28-36.
Because the postmortem changes rapidly distort values of many constituents in the body fluids, the determination of postmortem chemical changes and relation among body fluids is very important in medicolegal...
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Evaluation of bioequivalence of two enrofloxacin formulations after intramuscular administration in goats

Aboubakr M

  • KMID: 1991774
  • Korean J Vet Res.
  • 2013 Jun;53(2):77-82.
The present study was planned to evaluate the bioequivalence of two commercial formulations of enrofloxacin, which have been marketed as 10% injectable solution after intramuscular administration at a single dose...
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The Discriminatiuon between Congenital and Acquired Color Vision Defects by Computerized Color Vision Test

Shin YJ, Choi SY, Park KH, Kim MS, Hwang JM, Wee WR, Lee JH, Lee IB, Yu YS, Choi JH

  • KMID: 2207588
  • J Korean Ophthalmol Soc.
  • 2005 Jan;46(1):125-132.
PURPOSE: To investigate the characteristics of congenital and acquired color vision defects with Seohan computerized hue test and SNU (Seoul National University) computerized color test and to help to discriminate...
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Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China

Wei XS, Wei CD, Tong YQ, Zhu CL, Zhang PA

  • KMID: 2386473
  • Yonsei Med J.
  • 2014 Mar;55(2):428-434.
PURPOSE: To analyze the correlation of polymorphisms of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han population. MATERIALS AND...
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Validity of Self-Reported Height, Weight, and Body Mass Index of the Korea Youth Risk Behavior Web-Based Survey Questionnaire

Bae J, Joung H, Kim JY, Kwon KN, Kim Y, Park SW

OBJECTIVES: Self-reported anthropometric values, such as height and weight, are used to calculate body mass index (BMI) and assess the prevalence of obesity among adolescents. The aim of this study...
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Are Hemorrhoids Associated with False-Positive Fecal Immunochemical Test Results?

Kim NH, Park JH, Park DI, Sohn CI, Choi K, Jung YS

PURPOSE: False-positive (FP) results of fecal immunochemical tests (FITs) conducted in colorectal cancer (CRC) screening could lead to performing unnecessary colonoscopies. Hemorrhoids are a possible cause of FP FIT results;...
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Rethinking Statistical Approaches to Evaluating Drug Safety

Liu JP

PURPOSE: The current methods used to evaluate the efficacy of drug products are inadequate. We propose a non-inferiority approach to prove the safety of drugs. MATERIALS AND METHODS: Traditional...
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Arterial Stiffness is Associated With Diabetic Retinopathy in Korean Type 2 Diabetic Patients

Yun YW, Shin MH, Lee YH, Rhee JA, Choi JS

OBJECTIVES: We evaluated the association between common carotid artery intima-media thickness (CCA-IMT), brachial-ankle pulse wave velocity (baPWV), carotid plaque, and peripheral arterial disease (PAD) as indicators of macroangiopathy and diabetic...
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Certain Polymorphisms in SP110 Gene Confer Susceptibility to Tuberculosis: A Comprehensive Review and Updated Meta-Analysis

Zhang S, Wang XB, Han YD, Wang C, Zhou Y, Zheng F

PURPOSE: Numerous studies have assessed the association of SP110 gene variants with tuberculosis (TB), but the results were inconsistent. Through a comprehensive review and meta-analysis, our study aimed to clarify...
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Patient's Perception of Symptoms Related to Morning Activity in Chronic Obstructive Pulmonary Disease: The SYMBOL Study

Kim YJ, Lee BK, Jung CY, Jeon YJ, Hyun DS, Kim KC, Yu SK, Choi HS, Shin WH, Lee KH

  • KMID: 2432935
  • Korean J Intern Med.
  • 2012 Dec;27(4):426-435.
BACKGROUND/AIMS: Patients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to...
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Dose-Response Relationship between Alanine Aminotransferase Levels within the Reference Interval and Metabolic Syndrome in Chinese Adults

Wu P, Chen Q, Chen L, Zhang P, Xiao J, Chen X, Liu M, Wang S

PURPOSE: Elevation in serum alanine aminotransferase (ALT) levels is a biomarker for metabolic syndrome (MS); however, the relationship has not been fully investigated within the reference interval of ALT levels....
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Prevalence of Mental Disorders in Family Practice Centers in Korea and the Utility of a Diagnostic Tool

Kim YS, Yoon YS, Oh JY, Ryu HT, Kim DH, Suh YS, Kim BS, Kim YJ, Song SW, Lee J

  • KMID: 2294643
  • J Korean Acad Fam Med.
  • 2005 Nov;26(11):699-705.
BACKGROUND: A considerable portion of patients in primary care are thought to have mental disorders in Korea. But they are not easily noticed and are thus underdiagnosed and approached improperly....
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A Combination of Melphalan, Prednisone, and 50 mg Thalidomide Treatment in Non-Transplant-Candidate Patients with Newly Diagnosed Multiple Myeloma

Chang HJ, Lee JH, Do YR, Bae SH, Lee JL, Nam SH, Yoon SS, Bang SM

BACKGROUND/AIMS: The clinical efficacy and safety of a three-drug combination of melphalan, prednisone, and thalidomide were assessed in patients with multiple myeloma who were not candidates for high-dose therapy as...
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Sound Analysis in an In Vitro Endotracheal Tube Model

Park YS, Kee YW, Park KS, Lee J, Lee SM, Yim JJ, Yoo CG, Kim YW, Han SK, Yang SC

BACKGROUND/AIMS: Complete endotracheal tube obstruction is a medical emergency, and partial occlusion causes increased breathing rates and failure to wean off mechanical ventilation. Partial occlusion may be underestimated due to...
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