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Methionine Enhances the Contractile Activity of Human Colon Circular Smooth Muscle In Vitro

Choe EK, Moon JS, Park KJ

Effective drug to manage constipation has been unsatisfactory. We sought to determine whether methionine has effect on the human colon. Human colon tissues were obtained from the specimens of colon...
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Relationship between ganglioside expression and anti-cancer effects of the monoclonal antibody against epithelial cell adhesion molecule in colon cancer

Kwak DH, Ryu JS, Kim CH, Ko K, Ma JY, Hwang KA, Choo YK

The human colorectal carcinoma-associated GA733 antigen epithelial cell adhesion molecule (EpCAM) was initially described as a cell surface protein selectively expressed in some myeloid cancers. Gangliosides are sialic acid-containing glycosphingolipids...
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Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling

Lee JS, Park SY, Thapa D, Choi MK, Chung IM, Park YJ, Yong CS, Choi HG, Kim JA

TNF-alpha is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through...
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Cisapride in chronic idiopathic constipation: clinical response and effect on colonic transit time

Bak YT, Kim JH, Lee CH

  • KMID: 1051557
  • Korean J Intern Med.
  • 1996 Jun;11(2):151-156.
OBJECTIVES: To evaluate the effect of cisapride on the total and segmental colonic transit times (CTT's) and on the clinical symptoms in patients with chronic idiopathic constipation, and to elucidate...
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Alteration of nitrergic neuromuscular transmission as a result of acute experimental colitis in rat

Sung TS, La JH, Kim TW, Yang IS

Nitric oxide (NO) is a non-adrenergic, non-cholinergic neurotransmitter found in the enteric nervous system that plays a role in a variety of enteropathies, including inflammatory bowel disease. Alteration of nitrergic neurons has been reported...
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The Effects of Prucalopride on Postoperative Ileus in Guinea Pigs

Park SJ, Choi EJ, Yoon YH, Park H

PURPOSE: Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and...
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Malakoplakia in a healthy young female patient

Hyun KH, Shin HD, Kim DH

Malakoplakia is a rare granulomatous disease that occurs commonly in the urinary tract and secondarily in the gastrointestinal tract. Most reported cases of malakoplakia are associated with immunosuppressive diseases or...
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The Effect of Peripheral CRF Peptide and Water Avoidance Stress on Colonic and Gastric Transit in Guinea Pigs

Hussain Z, Kim HW, Huh CW, Lee YJ, Park H

Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) diseases; however, there is frequent overlap between FD and IBS patients. Emerging evidence links the activation of corticotropin...
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Benzoxazole Derivative B-98 Ameliorates Dextran Sulfate Sodium-induced Acute Murine Colitis and the Change of T Cell Profiles in Acute Murine Colitis Model

Song EM, Jung SA, Lee JS, Kim SE, Shim KN, Jung HK, Yoo K, Park HY

BACKGROUND/AIMS: The unique role of enzyme 5-lipoxygenase (5-LO) in the production of leukotrienes makes it a therapeutic target for inflammatory bowel disease (IBD). The aim of this study was to...
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