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Retiform Purpura Caused by the Use of Cocaine, That Was Probably Adulterated with Levamisole

Torregrosa Calatayud JL, Garcias Ladaria J, De Unamuno Bustos B, Zaragoza Ninet V, Alegre De Miquel V

No abstract available.
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Classic Studies on the Interaction of Cocaine and the Dopamine Transporter

Verma V

The dopamine transporter is responsible for recycling dopamine after release. Inhibitors of the dopamine transporter, such as cocaine, will stop the reuptake of dopamine and allow it to stay extracellularly,...
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Cocaine-Induced Behavioral Sensitization in Mice: Effects of Microinjection of Dopamine D2 Receptor Antagonist into the Nucleus Accumbens

Jung ES, Lee HJ, Sim HR, Baik JH

To determine the role of dopamine D2 receptor (D2R) in the nucleus accumbens (NAc) core in cocaine-induced behavioral sensitization, D2R antagonist, raclopride was bilaterally microinjected (2.5 or 5 nmol) into...
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Ritanserin, a 5HT2/1C receptor antagonist, does not block cocaine-induced behavioral alterations and zif268 mRNA expression in the striatum of the rats

Choe ES, Kim JY

  • KMID: 1580932
  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):355-359.
Cocaine induces immediate early gene expression and behavioral changes by blocking dopamine transporters in the terminals of nigrostriatal neurons in the striatum. The pharmacological role of serotonin 2/1C (5HT2/1C) receptors in cocaine-induced expression...
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Amperozide decreases cocaine-induced increase in behavior and immediate early gene expression in the dorsal striatum

Choe ES, Kim JY

  • KMID: 1580933
  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):361-367.
Cocaine functions as indirect dopamine and serotonin (5-hydroxytryptamine, 5HT) agonists and induces genomic and behavioral alterations in the striatum. Previously we demonstrated that ritanserin, a 5HT2/1C receptor antagonist, is not responsible for cocaine-induced behavioral...
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Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases

Roncero C, Palma-Alvarez RF, Ros-Cucurull E, Barral C, Gonzalvo B, Corominas-Roso M, Casas M, Grau-Lopez L

Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to...
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A Review on Renal Toxicity Profile of Common Abusive Drugs

Singh VP, Singh N, Jaggi AS

Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal...
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Effects of Clozapine, Haloperidol, and Fluoxetine on the Reversal of Cocaine-Induced Locomotor Sensitization

Cha SK, Kang UG

OBJECTIVE: Repeated treatment with psychostimulants induces sensitization of the dopaminergic system in the brain. Dopaminergic sensitization has been proposed as a mechanism of psychosis. Although antipsychotics block the expression of...
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Blockade of ERK Phosphorylation in the Nucleus Accumbens Inhibits the Expression of Cocaine-induced Behavioral Sensitization in Rats

Kim S, Shin JK, Yoon HS, Kim JH

Repeated administration of psychostimulants such as cocaine leads to the development of behavioral sensitization. Extracellular signal-Regulated Kinase (ERK), an enzyme important for long-term neuronal plasticity, has been implicated in such...
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Metoprolol treatment of dual cocaine and bupropion cardiovascular and central nervous system toxicity

Richards J, Gould JB, Laurin EG, Albertson

Cardiovascular and central nervous system (CNS) toxicity, including tachydysrhythmia, agitation, and seizures, may arise from cocaine or bupropion use. We report acute toxicity from the concomitant use of cocaine and...
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Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration

Hu Z, Oh EH, Chung YB, Hong JT, Oh KW

The aim of this study was to investigate the involvement of dopaminergic receptors (DR) in behavioral sensitization, as measured by locomotor activity, and the over-expression of cocaine- and amphetamine-regulated transcript...
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Experimental Study on the Ciliary Ganglion and Pupil

Chang BL

  • KMID: 1902455
  • J Korean Ophthalmol Soc.
  • 1977 Dec;18(4):347-349.
Using albino rabbits, auther studied pupillary response on various drugs after destruction of ciliary ganglion or its post ganglionic fibers. Right eye was used as experimental group and left eye...
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Interactions of Dopamine D1 and N-methyl-D-Aspartate Receptors are Required for Acute Cocaine-Evoked Nitric Oxide Efflux in the Dorsal Striatum

Lee DK, Ahn SM, Shim YB, Koh WC, Shim I, Choe ES

Alterations in nitric oxide (NO) release in response to psychostimulants in the striatum cause a plastic change contributing to the development and expression of addiction. In this study, regulation of...
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The functional domains of dopamine transporter for cocaine analog, CFT binding

Lee SH, Chang MY, Jeon DJ, Oh DY, Son H, Lee CH, Lee YS, Lee YS

  • KMID: 1093603
  • Exp Mol Med.
  • 2002 Mar;34(1):90-94.
Cocaine analogue, CFT (2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane) binding to dopamine transporter (DAT) in different species is quite heterogeneous. CFT is scarcely detected in bovine DAT whereas it is conspicuous in humans. To...
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A Case of Acute Dissection of the Aorta Associated with Methamphetamine Abuse

Han SW, Kim KS, Kim MJ, Han SB

  • KMID: 2204307
  • J Korean Soc Echocardiogr.
  • 1999 Jul;7(1):75-79.
Acute aortic dissection is a medical emergency requiring prompt diagnosis and management. To our knowledge, there have been no reports associating acute dissection of the aorta with methamphetamine abuse in...
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NHS Hospital Pharmacist Training Programme in UK

Kim YJ

The aim of the research was to explore post-registration training opportunities for NHS hospital pharmacists which contributes to promote structural reform of the professional development and lifelong learning for Korean...
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Practical Use and Risk of Modafinil, a Novel Waking Drug

Kim D

  • KMID: 2380174
  • Environ Health Toxicol.
  • 2012 ;27(1):e2012007.
OBJECTIVES: Modafinil is a waking drug prescribed to narcolepsy patients, but its usage among healthy individuals is increasing to enhance their alertness or to mitigate fatigue. This study was conducted...
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Experimental Models of Schizophrenia

Cheon JS

  • KMID: 2334614
  • J Korean Soc Biol Psychiatry.
  • 1999 Nov;6(2):153-160.
Animal models can provide a useful tool for the study of some aspects of psychiatric disorders and their treatment. The four criteria for the evaluation of animal models of psychiatric...
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A Case of Ischemic Colitis Following Oral OsmoticLaxative for Bowel Preparation

Lee CK, Lee SH, Lee JY, Kim SP, Chung IK, Kim SJ, Cho HD

  • KMID: 2174095
  • Intest Res.
  • 2008 Dec;6(2):135-139.
Ischemic colitis is the most prevalent form of ischemic vascular compromise of the gastrointestinal tract. Although frequent in the elderly with co-morbidity, numerous pharmacologic agents including diuretics, pseudoephedrine, nonsteroidal anti-inflammatory...
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Alcoholic Drinking

Yang JM

Alcohol abuse is one of the most significant healthrelated drug problems in many countries. Although cocaine and other illegal drugs receive much more attention from governments and news media, these...
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