- Trends of clinical trials from 2014 to 2016 in South Korea
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Huh KY, Hwang JG, Lee S
- KMID: 2429513
- Transl Clin Pharmacol.
- 2018 Dec;26(4):172-176.
- doi: 10.12793/tcp.2018.26.4.172
Mandatory registration of clinical trials in public registry can ensure the transparency of clinical trials. Public clinical trial registry of can provide current chronological and geographical distribution of clinical trial... -
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- Are You "Tilting at Windmills" or Undertaking a Valid Clinical Trial?
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Steeves JD, Zariffa J, Kramer JL
- KMID: 1108061
- Yonsei Med J.
- 2011 Sep;52(5):701-716.
- doi: 10.3349/ymj.2011.52.5.701
In this review, several aspects surrounding the choice of a therapeutic intervention and the conduct of clinical trials are discussed. Some of the background for why human studies have evolved... -
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- Stages of Institutional Review Board Activities
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No authors listed
- KMID: 1099784
- J Korean Med Sci.
- 2003 Feb;18(1):1-2.
- doi: 10.3346/jkms.2003.18.1.1
No abstract available. -
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- The Review of Chemotherapeutric Trials on Leprosy and its Present States in Korea
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Lew J
- KMID: 687772
- Yonsei Med J.
- 1979 Jun;20(1):52-55.
- doi: 10.3349/ymj.1979.20.1.52
No abstract available. -
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- The potential use of mesenchymal stem cells in hematopoietic stem cell transplantation
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Kim EJ, Kim N, Cho SG
- KMID: 2154221
- Exp Mol Med.
- 2013 Jan;45(1):e2.
In the last 10 years, mesenchymal stem cells (MSCs) have emerged as a therapeutic approach to regenerative medicine, cancer, autoimmune diseases, and many more due to their potential to differentiate... -
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- Independent Data Monitoring Committees: Review of Current Guidelines
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Lee BR, Lee KE
- KMID: 2358070
- Korean J Clin Pharm.
- 2016 Jun;26(2):181-186.
- doi: 10.0000/kjcp.2016.26.2.181
BACKGROUND: There has been on increasing emphasis on the importance of monitoring the safety of participants in a clinical trial to protect patients and maintain the integrity of the trial.... -
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- Spinal Cord Injury and Related Clinical Trials
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Kim YH, Ha KY, Kim SI
- KMID: 2412297
- Clin Orthop Surg.
- 2017 Mar;9(1):1-9.
- doi: 10.4055/cios.2017.9.1.1
Spinal cord injury (SCI) has been considered an incurable condition and it often causes devastating sequelae. In terms of the pathophysiology of SCI, reducing secondary damage is the key to... -
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- FTY720: Mechanism of Action and Potential Benefit in Organ Transplantation
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Brinkmann
- KMID: 1726160
- Yonsei Med J.
- 2004 Dec;45(6):991-997.
- doi: 10.3349/ymj.2004.45.6.991
FTY720 is a novel immunomodulator that has proven effective in animal models of transplantation and autoimmunity, has achieved promising results in Phase I and Phase II studies of renal transplantation... -
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- Clinical Trials with Stem Cells in Digestive Diseases and Future Perspectives
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Kim TI
- KMID: 1018401
- Korean J Gastroenterol.
- 2011 Sep;58(3):139-143.
- doi: 10.4166/kjg.2011.58.3.139
Many techniques for isolation, expansion and handling of stem cells are being developed rapidly, and preclinical evidence has shown the possibility to use this technology for refractory diseases in the... -
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- Review of the Registration in the Clinical Research Information Service
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Choi EK, Kim MJ, Lim NK, Park HY
- KMID: 2359984
- J Korean Med Sci.
- 2016 Jan;31(1):1-8.
- doi: 10.3346/jkms.2016.31.1.1
Clinical research registration is required in many countries to improve transparency of clinical research and to ensure subject safety. Developed in February 2010, the Clinical Research Information Service (CRIS) is... -
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- Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment
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Oh H, Jun DW, Saeed WK, Nguyen MH
- KMID: 2373132
- Clin Mol Hepatol.
- 2016 Sep;22(3):327-335.
- doi: 10.3350/cmh.2016.0049
The prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to be 25-30% of the population, and is the most common cause of elevated liver enzymes in Korea. NAFLD is... -
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- Clinicoepidemiological research designs in childhood allergic diseases
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Yang HJ
- KMID: 2361280
- Allergy Asthma Respir Dis.
- 2016 Mar;4(2):91-99.
- doi: 10.4168/aard.2016.4.2.91
Clinical epidemiology is defined as a method for investigating the distribution and determinants of diseases and for applying this knowledge in their prevention, and simply means application of epidemiological methods... -
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- Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials
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Song GG, Bae SC, Lee YH
- KMID: 1794631
- Korean J Intern Med.
- 2014 Sep;29(5):656-663.
- doi: 10.3904/kjim.2014.29.5.656
BACKGROUND/AIMS: The aim of this study was to assess the efficacy and safety of tofacitinib (5 and 10 mg twice daily) in patients with active rheumatoid arthritis (RA). METHODS: A systematic... -
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- Integrating Evidence for Managing Asthma in Patients Who Smoke
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Price D, Bjermer L, Popov TA, Chisholm A
- KMID: 2260254
- Allergy Asthma Immunol Res.
- 2014 Mar;6(2):114-120.
- doi: 10.4168/aair.2014.6.2.114
Cigarette smoking among asthma patients is associated with worsening symptoms and accelerated decline in lung function. Smoking asthma is also characterized by increased levels of neutrophils and macrophages, and greater... -
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- Effect of Brace to Osteoporotic Vertebral Fracture: a Meta-Analysis
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Jin YZ, Lee JH
- KMID: 2468257
- J Korean Med Sci.
- 2016 Oct;31(10):1641-1649.
- doi: 10.3346/jkms.2016.31.10.1641
Brace is one of the most commonly used interventions to manage osteoporotic vertebral fracture. However, its authentic effectiveness remains unclear. The aim of this study was to investigate the efficacy... -
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- FK778, A Synthetic Malononitrilamide
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Fitzsimmons WE, First MR
- KMID: 1726179
- Yonsei Med J.
- 2004 Dec;45(6):1132-1135.
- doi: 10.3349/ymj.2004.45.6.1132
FK778 is a synthetic malononitrilamide (MNA) that has been demonstrated to have both both immunosuppressive and anti-proliferative activities. The MNAs inhibit both T-cell and B-cell function by blocking de novo... -
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- Targeted Cancer Therapy Using Engineered Salmonella typhimurium
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Zheng JH, Min JJ
- KMID: 2432267
- Chonnam Med J.
- 2016 Sep;52(3):173-184.
- doi: 10.4068/cmj.2016.52.3.173
Obligate or facultative anaerobic bacteria such as Bifidobacterium, Clostridium, Salmonella, or Escherichia coli specifically colonize and proliferate inside tumor tissues and inhibit tumor growth. Among them, attenuated Salmonella typhimurium (S.... -
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- Systematic Review and Meta-Analysis of Pulmonary Hypertension Specific Therapy for Exercise Capacity in Chronic Obstructive Pulmonary Disease
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Park J, Song JH, Park DA, Lee JS, Lee SD, Oh YM
- KMID: 1793026
- J Korean Med Sci.
- 2013 Aug;28(8):1200-1206.
- doi: 10.3346/jkms.2013.28.8.1200
Some patients with chronic obstructive pulmonary disease (COPD) have pulmonary hypertension (PH) that adversely affects survival. We performed a systematic review and meta-analysis to assess whether PH-specific therapies have an... -
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- The Role of Pharmacoethnicity in the Development of Cytotoxic and Molecular Targeted Drugs in Oncology
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Saijo N
- KMID: 1776911
- Yonsei Med J.
- 2013 Jan;54(1):1-14.
- doi: 10.3349/ymj.2013.54.1.1
The effective and toxic ranges of anticancer drugs are very narrow and, in some cases, inverted. Thus determination of the most appropriate dosage and schedule of administration is crucial for... -
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- Assessment of statistical power for covariate effects in data from phase I clinical trials
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Kim Y, Son H, Son M, Lee D, Heo YA, Park K
- KMID: 2148857
- Transl Clin Pharmacol.
- 2015 Jun;23(1):31-34.
- doi: 10.12793/tcp.2015.23.1.31
One of the important purposes in population pharmacokinetic studies is to investigate the relationships between parameters and covariates to describe parameter variability. The purpose of this study is to evaluate... -
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