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Signaling Pathways in Osteoclast Differentiation

Kim JH, Kim N

Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor...
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No-Reflow Phoenomenon by Intracoronary Thrombus in Acute Myocardial Infarction

Lim SY

Recently, percutaneous coronary intervention has been the treatment of choice in most acute myocardial infarction cases. Although the results of percutaneous coronary interventions have ben good, the no-reflow phenomenon and...
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HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases

Yoon S, Eom GH

Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also post-transcriptional modifiers that regulate the protein acetylation implicated in...
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Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes

Lim HS, Jin S, Yun SJ

As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and...
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Association of APOE Genotype with Bone Mineral Density in Men and Women: The Dong-gu and Namwon Studies

Kim SA, Kweon SS, Choi JS, Rhee JA, Lee YH, Nam HS, Jeong SK, Park KS, Ryu SY, Choi SW, Kim HN, Song HR, Oh SH, Cauley JA, Shin MH

Many studies have investigated relationships between APOE genotype and bone mineral density (BMD). However, the results of these studies have been inconsistent. Few studies have been carried out in Asian...
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The Neurobiology of Bipolar Disorder: An Integrated Approach

Muneer A

Bipolar disorder is a heterogeneous condition with myriad clinical manifestations and many comorbidities leading to severe disabilities in the biopsychosocial realm. The objective of this review article was to underline...
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The Effects of Air Pollution on Ischemic Stroke Admission Rate

Alimohammadi H, Fakhri S, Derakhshanfar H, Hosseini-Zijoud SM, Safari S, Hatamabadi HR

The present study aimed to determine the relationship between the level of air pollutants and the rate of ischemic stroke (IS) admissions to hospitals. In this retrospective cross-sectional study, stroke...
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The Diagnostic Value of Pelvic Ultrasound in Girls with Central Precocious Puberty

Lee SH, Joo EY, Lee JE, Jun YH, Kim MY

The gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for differentiating central precocious puberty (CPP) from exaggerated thelarche (ET). Because of this test's limitations, previous studies have clarified the...
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Clinical and Laboratory Characteristics of Childhood Diabetes Mellitus: A Single-Center Study from 2000 to 2013

Park TH, Kim MS, Lee DY

We examined the clinical and laboratory characteristics of children newly diagnosed with diabetes mellitus (DM) in a single-center study. We retrospectively reviewed the data of 155 children with DM between...
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