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Pragmatic Clinical Trials

Doorenbos AZ, Chae D

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Introduction to dynamical systems analysis in quantitative systems pharmacology: basic concepts and applications

Chae D

Quantitative systems pharmacology (QSP) can be regarded as a hybrid of pharmacometrics and systems biology. Here, we introduce the basic concepts related to dynamical systems theory that are fundamental to...
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The Significance of Tartrate Resistant Acid Phosphatase as a Marker of osteoclast

Lee S, Chae D, Jang W, Jeon S, Chang J

Tatrate resistant acid phosphatase (TRAP) has been widely used as histochemical marker to identify osteoclast in studies of bone metabolism. However, the value of TRAP as an osteoclast marker is...
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Factors Affecting the Social Distance between Minority Groups and Nursing Cadets

Kang KH, Woo CH, Chae D

PURPOSE: The purpose of this study was to identify factors affecting the social distance between minority groups and nursing cadets. METHODS: A cross-sectional survey design was used. A questionnaire was distributed...
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Radiological Analysis of the Proximal Femoral Geometry in Korean Adults and the Design of the Cementless Femoral Stem

Shon W, Lee S, Chae D, Chang O

We analyzed the endosteal morphology of the proximal femur in 300 Korean adults radiologically and assessed the proximal canal filling of the cementless anatomic stem in 100 patients with imaging...
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Data science and machine learning in anesthesiology

Chae D

Machine learning (ML) is revolutionizing anesthesiology research. Unlike classical research methods that are largely inference-based, ML is geared more towards making accurate predictions. ML is a field of artificial intelligence...
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Comparison of the Effects of an App-based and Poster-based Self-managed Workplace Stretching Program on Musculoskeletal Symptoms of Workers in Small Manufacturing Businesses

Lee RS, Chae D, Kim J

Purpose: This study aimed to compare the effects of an 8 week, self-managed, app-based and poster-based stretching program on musculoskeletal symptoms, flexibility, stretching frequency, self-efficacy, social support, and musculoskeletal disorder...
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Relationship between body weight and postmenstrual age in a Korean pediatric population

Guk J, Chae D, Park K

Weight is a covariate representative of body size and is known to influence drug disposition. Recently, with increased use of allometric scaling, this variable has become more significant in accounting...
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Anti-inflammatory Effect of Plocamium telfairiae Extract in LPS-stimulated Bone Marrow-derived Macrophages and Dendritic Cells

Shrestha E, Kim S, Chae D, Manzoor Z, Yoo ES, Kang HK, Hyun JW, Ko MH, Koh YS

Marine algae are rich sources of various biologically active compounds with potential pharmaceutical properties. In the present study, we investigated the inhibitory effects of Plocamium telfairiae extract (PTE) on proinflammatory...
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Influencing Factors on Health-related Quality of Life among Japanese Middle-aged Marriage-based Immigrant Women in South Korea: A Cross-Sectional Study

Asami K, Chae D

Purpose With the first generation of marriage-based immigrant women in East Asia now reaching their middle or old age, the need to focus investigations on their health-related quality of life has...
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Development and Cross-Validation of the Short Form of the Cultural Competence Scale for Nurses

Chae D, Park Y

PURPOSE: To develop and validate the short form of the Korean adaptation of the Cultural Competence Scale for Nurses. METHODS: To shorten the 33-item Cultural Competence Scale for Nurses, an expert...
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Population pharmacodynamics of cilostazol in healthy Korean subjects

Jung YS, Chae D, Park K

Cilostazol is used for the treatment of intermittent claudication, ulceration and pain. This study was conducted to develop a population pharmacodynamic (PD) model for cilostazol's closure time (CT) prolongation effect...
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Characterization of circadian blood pressure patterns using non-linear mixed effects modeling

Chae D, Kim Y, Park K

Characterizing the time course of baseline or pre-drug blood pressure is important in acquiring unbiased estimates of antihypertensive drug effect. In this study, we recruited 23 healthy male volunteers and...
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An imputation-based method to reduce bias in model parameter estimates due to non-random censoring in oncology trials

Chae D, Park K

In oncology trials, patients are withdrawn from study at the time when progressive disease (PD) is diagnosed, which is defined as 20% increase of tumor size from the minimum. Such...
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Experiences of Middle-aged Korean-Chinese Female Migrant Workers in Korea: With Focus on Risk Factors in Work-related Musculoskeletal Diseases

Lee H, Chae D, Lee K, Lee M

PURPOSE: This study was to explore situations that might put the middle-aged Korean-Chinese female migrant workers at risk for work-related musculoskeletal diseases (WMSDs). At the development phase of a continuing...
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Acrosorium polyneurum Extract Inhibits the LPS-Induced Inflammatory Response by Impairing the MAPK and NF-κB Pathways

Manzoor Z, Ali I, Chae D, Koh YS

Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the antiinflammatory...
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Public Health Center Service Experiences and Needs among Immigrant Women in South Korea

Chae D, Kim H, Seo M, Asami K, Doorenbos A

Purpose: To support implementation of comprehensive, person-centered healthcare, this study aimed to explore immigrant women's public health center (PHC) service experiences and needs while considering Photovoice's feasibility for this purpose....
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Agreement on Core Components of an E-Learning Cultural Competence Program for Public Health Workers in South Korea: A Delphi Study

Chae D, Kim H, Yoo JY, Lee J

PURPOSE: This study aimed to seek agreement on the core components of an e-learning cultural competence program for Korean public health workers (PHWs) while prioritizing educational content areas. METHODS: A two-round...
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Home-based walking intervention for middle-aged migrant women using 360-degree virtual videos and a wearable activity tracker: A mixed-methods pilot study

Chae D, Asami K, Kim J, Kim K, Ryu J, Doorenbos AZ

Purpose: To sustain behavior change, an intervention strategy that considers the contribution of affect to daily physical activity behavior regulation is needed. Although virtual reality-based physical activity interventions have the...
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