- Nickel (II)-induced apoptosis and G2/M enrichment
-
Lee SH, Kim DK, Seo YR, Woo KM, Kim CS, Cho MH
- KMID: 1109301
- Exp Mol Med.
- 1998 Sep;30(3):171-176.
Treatment with certain DNA-damaging agents induce a complex cellular response comprising pertubation of cell cycle progression and/or apoptosis on proliferating mammalian cells. Our studies were focused on the cellular effects of nickel (II)... -
- CITED
-
- Close
- SHARE
-
- Close
- Methyl-beta-cyclodextrin inhibits cell growth and cell cycle arrest via a prostaglandin E(2) independent pathway
-
Choi YA, Chin BR, Rhee DH, Choi HG, Chang HW, Kim JH, Baek SH
- KMID: 755669
- Exp Mol Med.
- 2004 Feb;36(1):78-84.
Methyl-beta-cyclodextrin, a cyclic oligosaccharide known for its interaction with the plasma membrane induces several events in cells including cell growth and anti-tumor activity. In this study, we have investigated the... -
- CITED
-
- Close
- SHARE
-
- Close
- Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells
-
Lee SH, Choi JG, Cho MH
- KMID: 648251
- J Korean Med Sci.
- 2001 Apr;16(2):165-168.
- doi: 10.3346/jkms.2001.16.2.165
Nickel compounds are carcinogenic to human and are potent inducers of kidney and lung tumors in experimental animals. In this study, the effects of nickel(II) acetate on apoptosis, cell cycle... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells
-
Lee E, Choi MK, Han IO, Lim SJ
- KMID: 1094159
- Exp Mol Med.
- 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells... -
- CITED
-
- Close
- SHARE
-
- Close
- Berberine Inhibited the Growth of Thyroid Cancer Cell Lines 8505C and TPC1
-
Park KS, Kim JB, Bae J, Park SY, Jee HG, Lee KE, Youn YK
- KMID: 1120201
- Yonsei Med J.
- 2012 Mar;53(2):346-351.
- doi: 10.3349/ymj.2012.53.2.346
PURPOSE: Thyroid cancer is the most common malignancy in Korean females and can be treated with good prognosis. However, drugs to treat aggressive types of thyroid cancer such as poorly... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Excretory/Secretory Products from Clonorchis sinensis and the Carcinogen Dimethylnitrosamine on the Proliferation and Cell Cycle Modulation of Human Epithelial HEK293T Cells
-
Kim EM, Kim JS, Choi MH, Hong ST, Bae YM
- KMID: 1720554
- Korean J Parasitol.
- 2008 Sep;46(3):127-132.
- doi: 10.3347/kjp.2008.46.3.127
Clonorchis sinensis is one of the most prevalent parasitic helminths in Korea. Although cholangiocarcinoma can be induced by C. sinensis infection, the underlying mechanism is not clearly understood. To assess... -
- CITED
-
- Close
- SHARE
-
- Close
- Autocrine Extracellular Signal-regulated Kinase Activation in Normal Human Keratinocytes is not Interrupted by Calcium Triggering and is Involved in the Control of Cell Cycle at the Early Stage of Calciuminduced Differentiation
-
Park GT, Kim HY, Kim EK, Yang JM
- KMID: 1713190
- J Korean Med Sci.
- 2007 Apr;22(2):290-297.
- doi: 10.3346/jkms.2007.22.2.290
Normal human epidermal keratinocytes (NHEK) respond to the autocrine activated extracellular signal-regulated kinase (ERK) signaling pathway, which contributes to the survival of keratinocytes. However, during the condition of calcium-induced differentiation,... -
- CITED
-
- Close
- SHARE
-
- Close
- The mechanism of antiproliferative effect of desferrioxamine on human hepatoma cell lines
-
Kim DY, Kim WH, Kang JK, Park IS, Kwon OH
- KMID: 1381218
- Yonsei Med J.
- 1994 Mar;35(1):62-71.
- doi: 10.3349/ymj.1994.35.1.62
We investigated the effect of desferrioxamine (DFO), an iron chelator, on the DNA synthesis and the cell cycle of cultured hepatoma cells. Using Hep 3B cells as the hepatoma cell... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells
-
Sohn J, Lee CH, Chung DJ, Park SH, Kim IS, Hwang WI
- KMID: 754987
- Exp Mol Med.
- 1998 Mar;30(1):47-51.
Panax ginseng roots have long been used as a medicinal herb in oriental countries. We have investigated anti-proliferative effects of lipid soluble Panax ginseng components on human renal cancer cell lines. Petroleum... -
- CITED
-
- Close
- SHARE
-
- Close
- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
-
Lee J, Hong EM, Jang JA, Park SW, Koh DH, Choi MH, Jang HJ, Kae SH
- KMID: 2363978
- Gut Liver.
- 2016 Mar;10(2):310-317.
- doi: 10.5009/gnl15195
BACKGROUND/AIMS: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to... -
- CITED
-
- Close
- SHARE
-
- Close
- Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver
-
Hong SH, Lee GD, Chung JY, Cho KS, Park SH, Kim IH, Jeong JS
- KMID: 755208
- Exp Mol Med.
- 2002 Nov;34(5):361-366.
Repetitive low dose thioacetamide (TA) treatment of hepatocytes was found to induce cells in G2 arrest. In the present study, an attempt was made to investigate alterations in expression of... -
- CITED
-
- Close
- SHARE
-
- Close
- Capsaicin-Induced Apoptosis of FaDu Human Pharyngeal Squamous Carcinoma Cells
-
Le TD, Jin DC, Rho SR, Kim MS, Yu R, Yoo H
- KMID: 1716886
- Yonsei Med J.
- 2012 Jul;53(4):834-841.
- doi: 10.3349/ymj.2012.53.4.834
PURPOSE: To investigate the anti-tumor effect of capsaicin on human pharyngeal squamous carcinoma cells (FaDu). MATERIALS AND METHODS: The expression of apoptosis/cell cycle-related proteins (or genes) was examined by reverse transcriptase-polymerase... -
- CITED
-
- Close
- SHARE
-
- Close
- Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells
-
Jung EJ, Kim CW, Kim DR
- KMID: 756329
- Exp Mol Med.
- 2008 Jun;40(3):276-285.
- doi: 10.3858/emm.2008.40.3.276
Tropomyosin-related kinase A (TrkA) plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types. Here we show that TrkA overexpression by the Tet-On... -
- CITED
-
- Close
- SHARE
-
- Close
- JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis
-
Moon DO, Kim MO, Kang CH, Lee JD, Choi YH, Kim GY
- KMID: 756210
- Exp Mol Med.
- 2009 Sep;41(9):665-677.
- doi: 10.3858/emm.2009.41.9.073
The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking cell-cycle progression and inducing apoptosis. Despite extensive study, the mechanism by which SP600125 inhibits mitosis-related... -
- CITED
-
- Close
- SHARE
-
- Close
- IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1
-
Yu SJ, Kim HS, Cho SW, Sohn J
- KMID: 1094082
- Exp Mol Med.
- 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the... -
- CITED
-
- Close
- SHARE
-
- Close
- Heterogeneous nuclear ribonuclear protein C is increased in the celecoxib-induced growth inhibition of human oral squamous cell carcinoma
-
Lee EJ, Kim SH, Kwark YE, Kim J
- KMID: 1094145
- Exp Mol Med.
- 2006 Jun;38(3):203-209.
Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) that is a critical factor in carcinogenesis, but precise mechanism of its action remains to be elucidated. Here we evaluated the inhibitory... -
- CITED
-
- Close
- SHARE
-
- Close
- Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1
-
Seo YJ, Kim BS, Chun SY, Park YK, Kang KS, Kwon TG
- KMID: 1123450
- J Korean Med Sci.
- 2011 Nov;26(11):1489-1494.
- doi: 10.3346/jkms.2011.26.11.1489
Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and... -
- CITED
-
- Close
- SHARE
-
- Close
- Miltefosine-Induced Apoptotic Cell Death on Leishmania major and L. tropica Strains
-
Khademvatan S, Gharavi MJ, Rahim F, Saki J
- KMID: 1715628
- Korean J Parasitol.
- 2011 Mar;49(1):17-23.
- doi: 10.3347/kjp.2011.49.1.17
The aim of this study was to assess the cytotoxic effects of various concentrations of miltefosine on Leishmania major (MRHO/IR/75/ER) and L. tropica (MHOM/IR/02/Mash10) promastigotes and to observe the programmed... -
- CITED
-
- Close
- SHARE
-
- Close
- Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3
-
Sung HJ, Choi SM, Yoon YS, An KS
- KMID: 1029923
- Exp Mol Med.
- 1999 Dec;31(4):174-178.
Tanshinone II-A is a derivative of phenanthrene-quinone isolated from Salvia miltiorrhiza BUNGE, a traditional herbal medicine that is known to induce antiinflammatory, anti-oxidative and cytotoxic activity. We have... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells
-
Hong YB, Kang HJ, Kim HJ, Rosen EM, Dakshanamurthy S, Rondanin R, Baruchello R, Grisolia G, Daniele S, Bae I
- KMID: 1123462
- Exp Mol Med.
- 2009 Mar;41(3):151-160.
- doi: 10.3858/emm.2009.41.3.018
Resveratrol has been reported to possess cancer preventive properties. In this study, we analyzed anti-tumor activity of a newly synthesized resveratrol analog, cis-3,4',5-trimethoxy-3'-hydroxystilbene (hereafter called 11b) towards breast and pancreatic... -
- CITED
-
- Close
- SHARE
-
- Close
