- Involvement of Oxidative Stress in Cisplatin-Induced Apoptosis in HeLa Cells
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Ko KH, Kim SH, Cho HJ, Oh SH, Kim HG, Park RG
- KMID: 1925291
- Korean J Obstet Gynecol.
- 2003 Dec;46(12):2410-2416.
OBJECTIVE: To determine whether oxidants are formed as part of the cisplatin-induced apoptotic process, intracellular markers of oxidative stress were examined. METHODS: Apoptotic death of HeLa cells by cisplatin was confirmed... -
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- Caspases Activation in Ultraviolet B-induced Apoptosis of G361 Human Melanoma Cell Line
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Park KC, Lim JG, Kim DS, Choi HO, Kim KH, Cho KH, Youn JI
- KMID: 2163992
- Ann Dermatol.
- 2000 Dec;12(4):243-246.
- doi: 10.5021/ad.2000.12.4.243
BACKGROUND: Ultraviolet B (UVB) irradiation can induce apoptosis of melanocytes and melanoma cells. However, mechanism of UVB-induced apoptosis of melanoma cells is not clarified yet. OBJECTIVE: Our purpose was to study... -
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- Epilepsy and Programmed Cell Death
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Seo DW
- KMID: 2053701
- Hanyang Med Rev.
- 2006 Feb;26(1):52-60.
Epilepsy is one of the most common episodic neurological diseases characterized by recurrent epileptic seizures. The seizures occur by synchronization of a neuronal network, which may cause disturbances in intracellular... -
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- Expression of Apoptosis Related Genes from HaCaT Cell after UVB Irradiation
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Kang MC, Lee KS
- KMID: 2425018
- Korean J Dermatol.
- 2009 Jul;47(7):790-797.
BACKGROUND: Ultraviolet B (UVB) radiation is a major harmful environmental factor causing cutaneous changes such as sunburn, skin aging and skin cancer. Excessive UVB irradiation induces apoptosis of keratinocytes through... -
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- Intracellular pH is a Critical Element in Apoptosis Triggered by GM-CSF Deprivation in TF1 Cells
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Yoon SR, Choi IP
- KMID: 2054230
- Immune Netw.
- 2003 Dec;3(4):268-275.
- doi: 10.4110/in.2003.3.4.268
BACKGROUND: Hemopoietic cells require the constant presence of growth factors for survival in vitro and in vivo. Caspases have been known as central executors of apoptotic cell death. We have,... -
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- Cytotoxic Activity from Curcuma zedoaria Through Mitochondrial Activation on Ovarian Cancer Cells
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Shin Y, Lee Y
- KMID: 2317844
- Toxicol Res.
- 2013 Dec;29(4):257-261.
alpha-Curcumene is one of the physiologically active components of Curcuma zedoaria, which is believed to perform anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we... -
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- Molecular Aspects of Radiotherapy
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Park HJ
- KMID: 2200190
- J Lung Cancer.
- 2003 Mar;2(1):10-15.
When tumor cells are exposed to ionizing radiation, various and complicated molecular biological changes take place leading to cell death, mutation, and recovery from sublethal damage. It has been known... -
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- Apoptosis: role in myeloid cell development
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Sarvothaman S, Undi RB, Pasupuleti SR, Gutti U, Gutti RK
- KMID: 2172770
- Blood Res.
- 2015 Jun;50(2):73-79.
- doi: 10.5045/br.2015.50.2.73
Hematopoiesis is the process that generates blood cells in an organism from the pluripotent stem cells. Hematopoietic stem cells are characterized by their ability to undergo self-renewal and differentiation. The... -
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- Sulindac Sulfide-induced Apoptosis is Caspase 3-Dependent in Maxillary Cancer Cells
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Kim DY, Song KS, Moon IS, Yoon JH
- KMID: 1611639
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Dec;45(12):1157-1161.
BACKGROUND AND OBJECTIVES: Head and neck cancer is the sixth most common cancer in human body. Squamous cell cancer (SCC) accounts for most of sinonasal cancers. Prediction of cancer development... -
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- Pattern of Apoptosis by NS398, a Selective COX-2 Inhibitor, in Hepatocellular Carcinoma Cell Lines
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Park MK, Kim MK, Kim JC, Sung YK
- KMID: 2166122
- Cancer Res Treat.
- 2005 Oct;37(5):313-317.
PURPOSE: NS398, a selective COX-2 inhibitor, is known to inhibit the growth of COX-2 expressing hepatocellular carcinoma cells. The present study investigated whether the cytotoxic effect of NS398 was COX-2... -
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- Effect of Hypoxia on the Signal Transduction of Apoptosis in Osteoblasts
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Park YJ, Oh ST, Kang KH, Kim SC
- KMID: 1976475
- Korean J Orthod.
- 2003 Dec;33(6):453-463.
Mammalian cell is critically dependent on a continuous supply of oxygen. Even brief periods of oxygen deprivation can result in profound cellular damage. The aim of this study was to... -
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- Anti-growth Effects of Imatinib and GNF5 via Regulation of Skp2 in Human Hepatocellular Carcinoma Cells
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Kim SH, Kim MO, Kim KR
- KMID: 2447448
- J Cancer Prev.
- 2018 Dec;23(4):170-175.
- doi: 10.15430/JCP.2018.23.4.170
BACKGROUND: Human hepatocellular carcinoma (HCC) is a common liver tumor and the main cause of cancer-related death. Tyrosine kinase inhibitors, such as imatinib and GNF5 which were developed to treat... -
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- Activation of Caspase-3 in Hydrogen Peroxide-Induced Apoptosis of Human Leukemia HL 60 Cells
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Jeon S, Woo CW, Lee J, Sohn J, Lee KC, Son C, Lee J
- KMID: 2278318
- Korean J Pediatr Hematol Oncol.
- 2004 Oct;11(2):228-235.
PURPOSE: Reactive oxygen species have been recognized as a common signaling mediator in diverse stimuli-induced apoptosis and hydrogen peroxide is a natural one of those reactive oxygen species. This study... -
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- Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction
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Chae YJ, Kim HS, Rhim HS, Kim BE, Jeong SW, Kim IK
- KMID: 1457543
- Exp Mol Med.
- 2001 Dec;33(4):284-292.
3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells. In this study, we analyzed the activation pathway of the caspase cascade involved... -
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- Mechanism of Neuronal Damage in Epilepsy
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Seo DW
- KMID: 2343223
- J Korean Neurol Assoc.
- 2006 Aug;24(4):301-310.
Epilepsy is one of the most common episodic neurological diseases, and patients with epilepsy may experience a range of neurological, psychological, and behavioral problems. Recurring seizures potentially contribute to the... -
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- Caspase 3 and Ki-67 Immunoreactivity and Its Correlation with Frequency of Apoptosis in Gastric Adenomas and Carcinomas
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Sohn JH, Chae SW, Choi KC, Shin HS
- KMID: 1725815
- Korean J Pathol.
- 2001 Aug;35(4):286-290.
BACKGROUND: Apoptosis, also known as programmed cell death, is under genetic control and is mediated by apoptosis-specific genes, certain oncogenes and tumor suppressor genes. Caspase 3, a group of cystein... -
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- Effect of Extracellular Signal-Regulated Kinase Inhibition on Oxysterol 7-Ketocholesterol-Induced Apoptosis
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Hwang JY, Lee SW, Han JH, Kim DE, Lee CS
- KMID: 1966474
- J Korean Neurol Assoc.
- 2011 Nov;29(4):317-325.
BACKGROUND: Defects in mitochondrial function have been shown to participate in the induction of neuronal cell injury. The extracellular-signal-regulated kinase (ERK) signaling pathway plays a crucial role in almost all... -
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- Modulation of Telomerase Activity and Human Telomerase Reverse Transcriptase Expression by Caspases and Bcl-2 Family Proteins in Cisplatin-Induced Cell Death
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Park YP, Choi SC, Cho MY, Song EY, Kim JW, Paik SG, Kim YK, Kim JW, Lee HG
- KMID: 2238837
- Korean J Lab Med.
- 2006 Aug;26(4):287-293.
- doi: 10.3343/kjlm.2006.26.4.287
BACKGROUND: Human telomerase is a ribonucleoprotein polymerase, which synthesizes telomeric repeat sequences, and human telomerase reverse transcriptase (hTERT) has been identified as the catalytic subunit, as well as the rate-limiting... -
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- Bcl-2 Family and Caspases are Involved in CoCl2-Induced Apoptosis of PC12 Cells
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Jung JY, Park HJ, Kim SH, Kim WJ
- KMID: 1512981
- Korean J Phys Anthropol.
- 2006 Jun;19(2):137-148.
Hypoxic/ischemic condition induces the neuronal apoptotic events, consequently resulting in neuronal damages. Cobalt chloride (CoCl2) could mimic the hypoxic condition including the production of reactive oxygen species (ROS). This study... -
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- Update of Research on Aminoglycoside Ototoxicity
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Byun JY
- KMID: 2277304
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2012 Jan;55(1):1-7.
- doi: 10.3342/kjorl-hns.2012.55.1.1
It has long been known that the major irreversible toxicity of aminoglycosides is ototoxicity. Among them, streptomycin and gentamicin are primarily vestibulotoxic, whereas amikacin, neomycin, dihydrosterptomycin, and kanamicin are primarily... -
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