- Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis
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Kim HS, Shen Q, Nam SW
- KMID: 2344168
- J Korean Med Sci.
- 2015 Oct;30(10):1375-1380.
- doi: 10.3346/jkms.2015.30.10.1375
A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of... -
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- Detection of Aberrant p16INK4A Methylation in Sera of Patients with Liver Cirrhosis and Hepatocellular Carcinoma
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Chu HJ, Heo J, Seo SB, Kim GH, Kang DH, Song GA, Cho M, Yang US
- KMID: 1785699
- J Korean Med Sci.
- 2004 Feb;19(1):83-86.
- doi: 10.3346/jkms.2004.19.1.83
Hepatocellular carcinomas (HCCs) show genomic alterations, including DNA rearrangements associated with HBV DNA integration, loss of heterozygosity, and chromosomal amplification. The genes most frequently involved are those encoding tumor suppressors.... -
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- Polymorphism in Codons 10 and 25 of the Transforming Growth Factor-beta1 Gene in Korean Population and in Patients with Liver Cirrhosis and Hepatocellular Carcinoma
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Kwon OS, Song SH, Ju KT, Chung MG, Park DK, Kim SS, Kim YS, Koo YS, Kim YK, Choi DJ, Kim JH, Hwang YJ, Byun KS, Lee CH
- KMID: 881585
- Korean J Gastroenterol.
- 2003 Sep;42(3):212-219.
BACKGROUND/AIMS: The genetic polymorphism of transforming growth factor-beta1 (TGF-beta1) at codons 10 and 25 which influences the production of TGF-beta1 is related to fibrogenesis in the lung and liver. We... -
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- PIK3CA Mutations in Hepatocellular Carcinoma in Korea
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Kim H, Park CK, Lee SJ, Rha SY, Park KH, Lim HY
- KMID: 2158221
- Yonsei Med J.
- 2013 Jul;54(4):883-887.
- doi: 10.3349/ymj.2013.54.4.883
PURPOSE: Phosphatidylinositol 3-kinases/AKT pathway plays a pivotal role in hepatocellular carcinoma (HCC). Mutant PIK3CA, encoding the p110a catalytic subunit, stimulates the AKT pathway and promotes cell growth in various cancers.... -
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- Gene Expression Profiling of Hepatocellular Carcinoma Derived Cancer Stem Like Cell under Hypoxia
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Choi SH, Lee SW, Ok M, Kim KS, Kim S, Ahn SH
- KMID: 2418927
- Yonsei Med J.
- 2017 Sep;58(5):925-933.
- doi: 10.3349/ymj.2017.58.5.925
PURPOSE: Cancer stem like cells (CSCs), with unlimited self-renewal potential and other stem cell characteristics, occur in several cancers including hepatocellular carcinoma (HCC). Although CSCs can initiate tumors, malignant proliferation,... -
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- Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma
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Yu GR, Kim SH, Park SH, Cui XD, Xu DY, Yu HC, Cho BH, Yeom YI, Kim SS, Kim SB, Chu IS, Kim DG
- KMID: 1090967
- Exp Mol Med.
- 2007 Oct;39(5):641-652.
The aim of this study was to identify molecular markers associated with oncogenic differentiation in hepatocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene... -
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- Promoter Methylation of E-cadherin in Hepatocellular Carcinomas and Dysplastic Nodules
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Kwon GY, Yoo BC, Koh KC, Cho JW, Park WS, Park CK
- KMID: 1095198
- J Korean Med Sci.
- 2005 Apr;20(2):242-247.
- doi: 10.3346/jkms.2005.20.2.242
In order to clarify the significance of E-cadherin methylation in multistep hepatocarcinogenesis, we examined the methylation status of the E-cadherin promoter region, using methylation-specific polymerase chain reaction in 64 hepatocellular... -
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- Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas
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Cho YG, Kim CJ, Song JH, Rhie DJ, Park YK, Kim SY, Nam SW, Yoo NJ, Lee JY, Park WS
- KMID: 1094150
- Exp Mol Med.
- 2006 Jun;38(3):247-255.
The potassium channels are ubiquitous multisubunit membrane proteins, and potassium-dependent alterations in the membrane potential play an important role in the proliferation of many types of cells. This study analyzed... -
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- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
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Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
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- Pharmacological Unmasking Microarray Approach-Based Discovery of Novel DNA Methylation Markers for Hepatocellular Carcinoma
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Jung N, Won JK, Kim BH, Suh KS, Jang JJ, Kang GH
- KMID: 1421610
- J Korean Med Sci.
- 2012 Jun;27(6):594-604.
- doi: 10.3346/jkms.2012.27.6.594
DNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes. To find novel DNA methylation markers in hepatocellular... -
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- Integrative Analysis of Microarray Data to Reveal Regulation Patterns in the Pathogenesis of Hepatocellular Carcinoma
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Chen J, Qian Z, Li F, Li J, Lu Y
- KMID: 2412162
- Gut Liver.
- 2017 Jan;11(1):112-120.
- doi: 10.5009/gnl16063
BACKGROUND/AIMS: The integration of multiple profiling data and the construction of a transcriptional regulatory network may provide additional insights into the molecular mechanisms of hepatocellular carcinoma (HCC). The present study... -
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- Hypermethylation of the RUNX3 gene in hepatocellular carcinoma
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Park WS, Cho YG, Kim CJ, Song JH, Lee YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY
- KMID: 1093462
- Exp Mol Med.
- 2005 Aug;37(4):276-281.
Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. Recently, RUNX3 gene, one of TGF-beta-Smads signaling transduction pathway genes, showed strong tumor-suppressor... -
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- Genes Associated with Recurrence of Hepatocellular Carcinoma: Integrated Analysis by Gene Expression and Methylation Profiling
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Yang JD, Seol SY, Leem SH, Kim YH, Sun Z, Lee JS, Thorgeirsson SS, Chu IS, Roberts LR, Kang KJ
- KMID: 1123442
- J Korean Med Sci.
- 2011 Nov;26(11):1428-1438.
- doi: 10.3346/jkms.2011.26.11.1428
Gene expression is suppressed by DNA methylation. The goal of this study was to identify genes whose CpG site methylation and mRNA expression are associated with recurrence after surgical resection... -
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- Role of Interleukin-28B Genetic Polymorphisms in Korean Patients with Hepatitis C Virus Infection
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Kil H, Jeong SH, Kim JW, Byoun YS, Min BY, Woo BH, Lee YJ, Kim YS
- KMID: 1774531
- Gut Liver.
- 2014 Jan;8(1):70-78.
BACKGROUND/AIMS: This study investigated the role of single nucleotide polymorphisms (SNPs) near the interleukin-28B (IL28B) gene with respect to clinical outcomes and the antiviral response in hepatitis C virus (HCV)... -
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- Correlation of Mutation and Immunohistochemistry of p53 in Hepatocellular Carcinomas in Korean People
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Lee SN, Park CK, Sung CO, Choi JS, Oh YL, Cho JW, Yoo BC
- KMID: 648791
- J Korean Med Sci.
- 2002 Dec;17(6):801-805.
- doi: 10.3346/jkms.2002.17.6.801
The degree of correlation between sequencing and immunohistochemisty (IHC) for detecting mutations of p53 has not been well established in human hepatocellular carcinoma (HCC). We analyzed 36 HCCs from... -
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- Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique
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Kim HJ, Jeong J, Park S, Jin YW, Lee SS, Lee SB, Choi D
- KMID: 2412193
- Gut Liver.
- 2017 Mar;11(2):261-269.
- doi: 10.5009/gnl15389
BACKGROUND/AIMS: Cancer is known to be a disease by many factors. However, specific results of reprogramming by pluripotency-related transcription factors remain to be scarcely reported. Here, we verified potential effects... -
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