- Potential Interaction of Plasmodium falciparum Hsp60 and Calpain
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Yeo SJ, Liu DX, Park H
- KMID: 2360146
- Korean J Parasitol.
- 2015 Dec;53(6):665-673.
- doi: 10.3347/kjp.2015.53.6.665
After invasion of red blood cells, malaria matures within the cell by degrading hemoglobin avidly. For enormous protein breakdown in trophozoite stage, many efficient and ordered proteolysis networks have been... -
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- Calpain inhibitors reduce the cornified cell envelope formation by inhibiting proteolytic processing of transglutaminase 1
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Kim SY, Bae CD
- KMID: 755018
- Exp Mol Med.
- 1998 Dec;30(4):257-262.
Calpain I (mu-calpain) and II (m-calpain) are well known calcium-activated neutral cysteine proteases. Many reports have shown that activation of calpain is related to cataract formation, neuronal degeneration, blood clotting, ... -
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- Systemic Administration of a Novel Calpain Inhibitor Attenuates Subarachnoid Hemorrhage Induced Vasospasm
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Kang SD
- KMID: 1955635
- J Korean Neurosurg Soc.
- 1998 Feb;27(2):146-153.
The calcium-sensitive neutral protease, calpain, is activated in the basilar artery after subarachnoid hemorrhage. Pathological activation of this proteolytic enzyme has been suggested to contribute to cerebral vasospasm after subarachnoid... -
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- AMPA Receptor-Induced Neuronal Cell Death in Rat Hippocampus Following Transient Global Ischemia: Relationship to Calpain and Caspase-3 Expression
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Jung Y, Hong S, Ko B
- KMID: 1894520
- Korean J Anat.
- 2003 Feb;36(1):77-88.
A central challenge in ischemia-induced neuronal death research is understanding the mechanisms by which apoptotic or necrotic cascades are initiated and affected. We tested potential roles for AMPA and NMDA receptor... -
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- A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells
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Jang J, Yoon Y, Oh DJ
- KMID: 2416091
- Kidney Res Clin Pract.
- 2017 Sep;36(3):224-231.
- doi: 10.23876/j.krcp.2017.36.3.224
BACKGROUND: Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ. There... -
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- Calbindin-D28K Prevents Staurosporin-induced Bax Cleavage and Membrane Permeabilization
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Choi WS, Oh YJ
- KMID: 2165519
- Exp Neurobiol.
- 2014 Jun;23(2):173-177.
- doi: 10.5607/en.2014.23.2.173
Calbindin-D28K has been implicated in the regulation of neuronal cell death. Previously, we demonstrated that calbindin-D28K prevents staurosporine (STS)-induced caspase activation and subsequent apoptosis in a neuronal cell line. However,... -
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- Spectrin Cleavage Induced by LLP-1 Lentivirus Lytic Peptide Domain in the Intracytoplasmic Tail of Human Immunodeficiency Virus Type 1 GP41 in Rat Organotypic Hippocampal Slice Cultures
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Lee JH, Lee EO, Chong YH
- KMID: 2055033
- J Bacteriol Virol.
- 2006 Dec;36(4):247-254.
- doi: 10.4167/jbv.2006.36.4.247
We previously demonstrated that the lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induced cell death in human neuronal cells. Present study was conducted to... -
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- Obesity Related Gene Variations
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Beck SH
- KMID: 2323296
- J Korean Soc Study Obes.
- 2004 Dec;13(4):221-229.
Obesity is a multifactorial disease in which various environmental and genetic factors interact. In this review article, 4 obesity related genetic variations are reviewed. PPAR gamma is a nuclear receptor... -
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- FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus
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Lee SH, Choi J, Kim H, Lee DH, Roh GS, Kim HJ, Kang SS, Choi WS, Cho GJ
- KMID: 1882579
- Anat Cell Biol.
- 2014 Jun;47(2):91-100.
- doi: 10.5115/acb.2014.47.2.91
Excessive immune responses induced by ischemia-reperfusion injury (IRI) are known to lead to necrotic and apoptotic cell death, and calcineurin plays a major role in this process. Calcineurin dephosphorylates the... -
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- Degradation of the Transcription Factors NF-kappaB, STAT3, and STAT5 Is Involved in Entamoeba histolytica-Induced Cell Death in Caco-2 Colonic Epithelial Cells
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Kim KA, Min A, Lee YA, Shin MH
- KMID: 1792210
- Korean J Parasitol.
- 2014 Oct;52(5):459-469.
- doi: 10.3347/kjp.2014.52.5.459
Entamoeba histolytica is a tissue-invasive protozoan parasite causing dysentery in humans. During infection of colonic tissues, amoebic trophozoites are able to kill host cells via apoptosis or necrosis, both of... -
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- Calpains are Involved in Entamoeba histolytica-Induced Death of HT-29 Colonic Epithelial Cells
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Jang YS, Song KJ, Kim JY, Lee YA, Kim KA, Lee SK, Shin MH
- KMID: 1090619
- Korean J Parasitol.
- 2011 Jun;49(2):177-180.
- doi: 10.3347/kjp.2011.49.2.177
Entamoeba histolytica is an enteric tissue-invading protozoan parasite that can cause amebic colitis and liver abscess in humans. E. histolytica has the capability to kill colon epithelial cells in vitro;... -
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- Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging
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Kim MJ, Oh SJ, Park SH, Kang HJ, Won MH, Kang TC, Park JB, Kim JI, Kim J, Lee JY
- KMID: 1103677
- Exp Mol Med.
- 2007 Feb;39(1):14-26.
Primary neuronal culture is a powerful tool to study neuronal development, aging, and degeneration. However, cultured neurons show signs of cell death after 2 or 3 weeks. Although the mechanism... -
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- Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats
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Kwon HH, Neupane C, Shin J, Gwon DH, Yin Y, Shin N, Shin HJ, Hong J, Park JB, Yi Y, Kim DW, Kang JW
- KMID: 2458550
- Exp Neurobiol.
- 2019 Aug;28(4):529-536.
- doi: 10.5607/en.2019.28.4.529
Stress can induce a serious epileptic encephalopathy that occurs during early infancy. Recent studies have revealed that prenatal stress exposure is a risk factor for the development of infantile spasms.... -
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- A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neurons
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Kim HN, Jang JY, Choi BT
- KMID: 1845277
- Anat Cell Biol.
- 2015 Jun;48(2):95-103.
- doi: 10.5115/acb.2015.48.2.95
We identified a neuroprotective single fraction among 62 ones of hexane extract from Uncaria sinensis (JGH43IA) and investigated its effects and mechanisms in primary cortical neurons. Pretreatment with JGH43IA showed... -
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- Association of Haplotype Combinations of Calpain-10 Gene Polymorphisms and the Metabolic Syndrome in Type 2 Diabetes
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Kang ES, Kim HJ, Myoung SM, Rhee Y, Ahn CW, Cha BS, Lim SK, Kim KR, Lee HC, Nam M
- KMID: 2008237
- J Korean Diabetes Assoc.
- 2005 Sep;29(5):451-459.
OBJECTIVE: Patients with metabolic syndrome are at increased risk of developing cardiovascular disease. The combinations of the haplotype created by the alleles of three single nucleotide polymorphisms (SNPs): SNP-43, SNP-19,... -
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- Calpain-10 Polymorphism in Korean Women with Polycystic Ovary Syndrome
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Lee HJ, Pyun GW, Byun EK, Oh JY, Oh JY, Hong Y, Sung YA, Chung HW
- KMID: 1479224
- J Korean Endocr Soc.
- 2008 Oct;23(5):319-326.
- doi: 10.3803/jkes.2008.23.5.319
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism and insulin resistance, and PCOS is known to be associated with an increased risk of type 2 diabetes mellitus... -
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- Cleavage of purified neuronal clathrin assembly protein (CALM) by caspase 3 and calpain
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Kim JA, Kim HL
- KMID: 1457537
- Exp Mol Med.
- 2001 Dec;33(4):245-250.
The most efficient means of protein internalization from the membrane are through clathrin-coated pits, which concentrate protein interactions with the clathrin-associated assembly protein complex AP-2 and internalization signals in the... -
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- NR1/NR2B receptor Activation induces Cytoskeletal Proteolysis in Partial Ischemic Rat Hippocampal Formation
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Jung YW, Moon IS, Ko BH
- KMID: 2030723
- Korean J Anat.
- 1997 Oct;30(5):439-452.
In the rat brain, partial ischemia causes a delayed neuronal degeneration that occurs hours to days after reoxygenation. It is generally thought that the ischemic damage is initiated by neurotoxicity... -
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- Mutations of CAPN3 in Korean Patients with Limb-Girdle Muscular Dystrophy
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Shin JH, Kim HS, Lee CH, Kim CM, Park KH, Kim DS
- KMID: 1778355
- J Korean Med Sci.
- 2007 Jun;22(3):463-469.
- doi: 10.3346/jkms.2007.22.3.463
The limb-girdle muscular dystrophy type 2A (LGMD2A) is a recessively inherited disease caused by a mutation of the calpain 3 gene (CAPN3), and is considered one of the most prevalent... -
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- Mechanisms of Muscle Wasting in Patients with Sepsis
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Lee GD, Kim HC
- KMID: 2301449
- Korean J Crit Care Med.
- 2010 Mar;25(1):9-15.
- doi: 10.4266/kjccm.2010.25.1.9
Muscle wasting is commonly seen in patients with sepsis as a consequence of the catabolic response in skeletal muscle. Muscle wasting can occur in cases that have an imbalance between... -
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