J Korean Diabetes Assoc.  2005 Sep;29(5):451-459.

Association of Haplotype Combinations of Calpain-10 Gene Polymorphisms and the Metabolic Syndrome in Type 2 Diabetes

• Kang ES
• Kim HJ
• Myoung SM
• Rhee Y
• Ahn CW
• Cha BS
• Lim SK
• Kim KR
• Lee HC
• Nam M

Abstract

OBJECTIVE
Patients with metabolic syndrome are at increased risk of developing cardiovascular disease. The combinations of the haplotype created by the alleles of three single nucleotide polymorphisms (SNPs): SNP-43, SNP-19, and SNP-63 of the Calpain 10 gene (CAPN10), have been reported to be associated with the risk of type 2 diabetes (T2DM) in many populations. The aim of this study was to examine the association of the CAPN10 polymorphisms with metabolic syndrome in Korean patients with T2DM.
METHODS
Overall, 382 T2DM patients were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, SNP-19 and SNP-63. The restriction fragment length polymorphism method was used for the three SNPs. The baseline presence of the components of metabolic syndrome was determined.
RESULTS
265 (69.4 %) patients were found to have metabolic syndrome. Patients with the 111/121 haplotype combination showed a higher risk of hypertension than the other haplotype combinations (OR=2.334, P=0.010) and also had a significantly higher risk of having metabolic syndrome (OR=1.927, P=0.042).
CONCLUSION
The results of this study suggest a role of the novel 111/121 haplotype combination created by the CAPN10 SNPs -43, -19 and -63 in the susceptibility to metabolic syndrome of T2DM patients.

Keyword

Calpain-10; Polymorphism; Haplotype; Metabolic Syndrome

MeSH Terms

Alleles
Calpain
Cardiovascular Diseases
Haplotypes*
Humans
Hypertension
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Calpain