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Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels

Noh J, Chung JM

Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state...
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Calcium Ions are Involved in Modulation of Melittin-induced Nociception in Rat: I. Effect of Voltage-gated Calcium Channel Antagonist

Shin HK, Le KH

  • KMID: 2071634
  • Korean J Physiol Pharmacol.
  • 2006 Oct;10(5):255-261.
Melittin-induced nociceptive responses are mediated by selective activation of capsaicin-sensitive primary afferent fibers and are modulated by excitatory amino acid receptor, cyclooxygenase, protein kinase C and serotonin receptor. The present...
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The Effect of Lambert-Eaton Syndrome IgG on Calcium Current in Rat Chromaffin Cells

Seo DW, Lee KW, Rho JK, Lee SB, Myung HJ, Kim SJ, Goo YS, Kim J

  • KMID: 2138117
  • J Korean Neurol Assoc.
  • 1993 Jun;11(2):209-221.
In rat chromaffin cells persistent inward calcium currents which were evoked by depolarizing step pulses from holding potential of-80mV, increased to a maximum amplitude at around +lOmV, became smaller with...
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Isolation of Voltage Dependent Calcium Current in Chick Inner Hair Cell

Lee SH, Shin MC, Ahn TH, Kim KY, Kim K, Min HJ, Park CW

BACKGROUND AND OBJECTIVES: Voltage dependent calcium channel (VDCC) mediates calcium ion influx and controls neurotransmitter release in excitable cells. Hair cells in vertebrates cochlea are known to express L-type VDCC....
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Effects of the Immunoglobulins of Amyotrophic Lateral Sclerosis on Intracellular Calcium in PC12 Cells

Kim SH, Jung SJ, Park KS, Kim M, Kim J, Kim HJ, Lee KW

  • KMID: 2342858
  • J Korean Neurol Assoc.
  • 2000 Nov;18(6):728-734.
BACKGROUND: The motor neuronal death in amyotrophic lateral sclerosis (ALS) arise from several mechanisms including excitotoxicity, oxidative stress, immunologic or calcium dysregulation. Though the immunoglobulin mediated neuronal death has been...
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Intracisternal Administration of Voltage Dependent Calcium Channel Blockers Attenuates Orofacial Inflammatory Nociceptive Behavior in Rats

Won KA, Park SH, Kim BK, Baek KS, Yoon DH, Ahn DK

  • KMID: 2170724
  • Int J Oral Biol.
  • 2011 Jun;36(2):43-50.
Voltage dependent calcium channel (VDCC), one of the most important regulator of Ca2+ concentration in neuron, play an essential role in the central processing of nociceptive information. The present study...
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The Effect of Carbon Monoxide on L-type Calcium Channel Currents in Human Intestinal Smooth Muscle Cells

Lim I

  • KMID: 1607521
  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):357-362.
Carbon monoxide (CO) is low molecular weight oxide gas that is endogenously produced under physiological conditions and interacts with another gas, nitric oxide (NO), to act as a gastrointestinal messenger....
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Reversal Effects of Neostigmine, Edrophonium and 4-aminopyridine of Verapamil Pretreatment on Pipecuronium Induced Neuromuscular Blockade in Rat-Hemidiaphragm

Park JW, Yoon SM

BACKGROUND: It has been shown that L-type calcium channel blockers increase the muscle relaxation effects of non-depolarizing neuromuscular blocking agents whereas the potentiated neuromuscular blocking effects by L-type calcium channel...
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The Role of Calcium Affecting Signal Pathway Related to Nitric Oxide-induced Cytotoxicity in H9c2 Cardiac Myoblast

Lee BH, Jung KM, Ahn BK, Mun YJ, Oh JM, Kim JJ, Choi MK, Park ST, Chung YT

  • KMID: 2224547
  • Korean J Anat.
  • 2000 Oct;33(5):587-594.
Nitric oxide (NO) elevates intracellular calcium. But the actions of calcium in NO-induced cell death are not well understood. This study was carried out to investigate the signal transduction pathways...
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Effects of arachidonic acid on the calcium channel current (I|B|a) and on the osmotic stretch-induced increase of I|B|a in guinea-pig gastric myocytes

Xu WX, Kim SJ, So I, Suh SH, Kim KW

  • KMID: 2071515
  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):435-443.
We employed the whole-cell patch clamp technique to investigate the effects of arachidonic acid (AA) on barium inward current through the L-type calcium channels (IBa) and on osmotic stretch-induced increase of IBa in...
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Effects of Propofol on Phenylephrine Induced Vascular Smooth Muscle Contraction in Rat Thoracic Aorta

Do H, Kim SO, Kim BK, Seo JW

BACKGROUND: Propofol decreases arterial blood pressure. This has been ascribed to vasodilation and decreased cardiac output occuring separately or in combination. The goal of the present study...
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An Arg1239His mutation of the CACNL1A3 gene in a Korean family with hypokalemic periodic paralysis

Yeo CY, Kim YO, Kim MK, Kim JY, Cho YK, Kim CJ, Woo YJ

Familial hypokalemic periodic paralysis (hypoPP) is a rare inherited channelopathy that often presents with episodic weakness accompanied by hypokalemia. Thus far, mutations in the gene encoding two ion channels (CACNL1A3,...
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Involvement of NMDA Receptor and L-type Calcium Channel in the Excitatory Action of Morphine

Koo BS, Shin HK, Kang SH, Jun JH

  • KMID: 2285258
  • Korean J Physiol Pharmacol.
  • 2002 Oct;6(5):241-246.
We studied the excitatory action of morphine on the responses of dorsal horn neuron to iontophoretic application of excitatory amino acid and C-fiber stimulation by using the in vivo electrophysiological...
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The Expression of L-type Calcium Channel mRNA by the Concentrations of Glucose on the Cell Proliferation in Cultured OLETF Rat Aortic Vascular Smooth Muscle Cells

Yoo HJ, Cho YJ, Nam HW

  • KMID: 2188600
  • J Korean Geriatr Soc.
  • 2004 Dec;8(4):191-195.
BACKGROUND: The proliferation of vascular smooth muscle cell(VSMC) is a part of the major pathogenic mechanism for atheroscle- rosis. It has been reported that L-type calcium channel plays a role...
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Relaxation Responses of Isolated Rabbit Seminal Vesicle to Polyamines

Myung SC, Lee SY, Kang GH, Keum EM, Lee MY, Kim SC

  • KMID: 2293954
  • Korean J Urol.
  • 2005 Feb;46(2):169-173.
PURPOSE: This study was designed to investigate the effects of polyamines on rabbit seminal vesicular contractility. MATERIALS AND METHODS: The polyamines; putrescine, spermidine and spermine, were added to deepithelized and precontracted...
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Influence of omega-Conotoxin GVIA, Nifedipine and Cilnidipine on Catecholamine Release in the Rat Adrenal Medulla

Yu BS, Kim BC, Lim DY

  • KMID: 1512914
  • Korean J Physiol Pharmacol.
  • 2007 Feb;11(1):21-30.
The present study was designed to establish comparatively the inhibitory effects of cilnidipine (CNP), nifedipine (NIF), and omega-conotoxin GVIA (CTX) on the release of CA evoked by cholinergic stimulation...
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Effect of Glucose Concentrations on the Cell Proliferation and Expression of L-type Calcium Channel mRNA in Cultured Rat Aortic Vascular Smooth Muscle Cells

Cho YJ, Yoo HJ, Nam HW, Suh JY, Jeong IK, Ihm SH, Kim HK, Park CY, Yoo JM, Kim DM, Choi MG, Park SW

  • KMID: 1768002
  • J Korean Diabetes Assoc.
  • 2003 Jun;27(3):253-259.
BACKGROUND: Vascular smooth muscle cell (VSMC) proliferation is one of the major pathogenic mechanisms for atherosclerosis. It is known that L-type calcium channels play a role in VSMC proliferation in...
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Nitric Oxide Synthase Mediates Carbon Monoxide-Induced Stimulation of L-type Calcium Currents in Human Jejunal Smooth Muscle Cells

Lim I, Yun J, Kim S, Myung S, Kim T, Bang H

  • KMID: 2285301
  • Korean J Physiol Pharmacol.
  • 2004 Jun;8(3):161-166.
Exogenous carbon monoxide (0.2%) increases L-type calcium (Ca2+) current in human jejunal circular smooth muscle cells. The stimulatory effect of carbon monoxide (CO) on L-type Ca2+ current is inhibited by...
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Angiotensin II-induced aortic ring constriction is mediated by phosphatidylinositol 3-kinase/L-type calcium channel signaling pathway

Do KH, Kim MS, Kim JH, Rhim BY, Lee WS, Kim CD, Bae SS

Angiotensin II (AngII) is a crucial hormone that affects vasoconstriction and exerts hypertrophic effects on vascular smooth muscle cells. Here, we showed that phosphatidylinositol 3-kinase-dependent calcium mobilization plays pivotal roles...
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Proliferation and Differentiation of Pancreatic beta Cells in L-type Calcium Channel alpha(1D) Subunit (Ca(v)1.3) Heterozygous Knock Out Mice After Partial Pancreatectomy

Choi YH, Yun IH, Suh SH, Lim DJ, Cho JH, Kwon HS, Cha BY, Son HY, Park CG, Yoon KH

BACKGROUNDS: L-type voltage-dependent calcium channel (LTCC) plays a crucial role in insulin secretion from pancreatic beta cells through Ca2+ influx. In the recent report, LTCC Ca(v)1.3 subtype homozygous knock out...
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