Korean J Anesthesiol.  2007 Feb;52(2):187-193. 10.4097/kjae.2007.52.2.187.

Effects of Propofol on Phenylephrine Induced Vascular Smooth Muscle Contraction in Rat Thoracic Aorta

• Do H
• Kim SO
• Kim BK
• Seo JW

• KMID: 2236622
• DOI: http://doi.org/10.4097/kjae.2007.52.2.187

Abstract

BACKGROUND
Propofol decreases arterial blood pressure. This has been ascribed to vasodilation and decreased cardiac output occuring separately or in combination. The goal of the present study was to assess the effects of propofol on the phenylephrine induced vasoconstriction in rat thoracic aortic rings.
METHODS
All aortic rings were removed endothelium and isometric tension was recorded under a resting tension of 3 g. Isolated aortic rings were precontracted with phenylephrine (0.3micrometer) and propofol (1 to 100micrometer) was added cumulatively. We induced the phenylephrine preconstriction after treatment of verapamil 10micrometer in the other vascular rings.
RESULTS
Propofol (1 to 100micrometer) attenuated phenylephrine (0.3micrometer) induced preconstriction dose-dependently. The administration of propofol (1 and 10micrometer) did not change the tonic constriction. The contractile response were significantly attenuated in verapamil pretreated rings but propofol did not affect on constriction in all dose range.
CONCLUSIONS
Propofol attenuated phenylephrine precontracted rat thoracic aortic rings with inhibition of Ca2+ movement through the L-type calcium channel in the sarcolemmal membrane.

Keyword

calcium channel; propofol; rat; verapamil

MeSH Terms

Animals
Aorta, Thoracic*
Arterial Pressure
Calcium Channels
Calcium Channels, L-Type
Cardiac Output
Constriction
Endothelium
Membranes
Muscle, Smooth, Vascular*
Phenylephrine*
Propofol*
Rats*
Vasoconstriction
Vasodilation
Verapamil
Calcium Channels
Calcium Channels, L-Type
Phenylephrine
Propofol
Verapamil