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Comparative Analysis of Dibutyric cAMP and Butyric Acid on the Differentiation of Human Eosinophilic Leukemia EoL-1 Cells

Jung Y

Purification of enough numbers of circulating eosinophils is difficult because eosinophils account for less than 5% peripheral blood leukocytes. Human eosinophilic leukemia EoL-1 cells have been considered an in vitro...
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The Differentiation of HL-60 Cells Causes to Lose their Ability to Express TNF mRNA

Kim JH, Han SJ, Park CS, Chung IY

  • KMID: 1550795
  • Korean J Immunol.
  • 1999 Mar;21(1):47-53.
It is well known that HL-60 cell, a human promyelocytic line, is differentiated into eosinophil-like cells in the presence of butyric acid, and thus the differentiated HL-60 cells have been...
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Adverse Side Effect of Baclofen: Case Report

Kim DY, Choi SM, Kim YS, Oh SH, Lee J

  • KMID: 1960281
  • J Korean Acad Rehabil Med.
  • 1997 Feb;21(1):229-233.
Baclofen(B-4-chlorphyl-r-amino butyric acid), a centrally acting gamma amino butyric acid (GABA) agonist is a commonly used pharmaceutics for spasticity of spinal cord lesion. It's effect includes activation of GABA recep...
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Multimodal Hallucination (Audio-visual, Kinaesthetic and Scenic) Associated with the Use of Zolpidem

Ram D, Eiman N, Gowdappa B

We are reporting a case of zolpidem induced multimodal hallucinations in a 22 year old female without any history of psychiatric disorders. Zolpidem, by acting on gamma-amino butyric acid type...
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Rat Intestinal Acetic Acid and Butyric acid and Effects of Age, Sex, and High-fat Diet on the Intestinal Levels in Rats

Choi SI, Kim N, Lee SM, Nam RH, Kang SR, Song CH, Park YT, Min H, Kim YR, Seok YJ

BACKGROUND: High-fat diet is known to be implicated in the pathogenesis of various metabolic disorders related to an inflammatory response. The aim of this study was to investigate the influence...
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The Effect of Microbiota on Colon Carcinogenesis

Yoon K, Kim N

Although genetic background is known to contribute to colon carcinogenesis, the exact etiology of the disease remains elusive. The organ’s extensive interaction with microbes necessitated research on the role of...
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Resistance Induction and Enhanced Tuber Production by Pre-inoculation with Bacterial Strains in Potato Plants against Phytophthora infestans

Kim HJ, Jeun YC

  • KMID: 2312481
  • Mycobiology.
  • 2006 Jun;34(2):67-72.
Efficacy of resistance induction by the bacterial isolates Pseudomonas putida (TRL2-3), Micrococcus luteus (TRK2-2) and Flexibacteraceae bacterium (MRL412), which were isolated from the rhizosphere of plants growing in Jeju Mountain,...
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The Effect of Topiramate on Status Epilepticus-Induced Neurotoxicity in Immature Mouse Brain

Park SS, Bae HR, Hwang KG

  • KMID: 2329571
  • J Korean Child Neurol Soc.
  • 2006 Nov;14(2):193-206.
PURPOSE:This study was performed to elucidate that status epilepticus (SE) induces long- term neuronal damages in an immature brain and to evaluate that topiramate (TPM) has a protective effect. METHODS:We investigated...
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NMDA Receptor-dependent Inhibition of Synaptic Transmission by Acute Ethanol Treatment in Rat Corticostriatal Slices

Choi SJ, Kim KJ, Cho HS, Kim SY, Yim DS, Cho YJ, Hahn SJ, Sung KW

  • KMID: 1587467
  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):303-307.
The effects of ethanol on corticostriatal synaptic transmission were examined, using extracellular recording and analysis of population spike amplitudes in rat brain slices, to study how acute ethanol intoxication impairs...
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Diagnosis and Treatment of Post-Stroke Delirium

Kim NY, Kim YW

Delirium is an acute disturbance of consciousness and cognition with fluctuating course over a short period of time. Recognition of delirium in post-stroke patients is important because of its association...
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Animal Models of Demyelination and ¹H-Magnetic Resonance Spectroscopy

Cho HB, Lee S, Park S, Kang I, Ma J, Jeong HS, Kim JE, Yoon S, Lyoo IK, Lim SM, Kim J

The proton magnetic resonance spectroscopy (¹H-MRS) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has...
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Treatment with sodium butyrate and rapamycin inhibit growth of human cervical cancer cells

Jeon YJ, Cho CH, Shin SJ, Kwon SH, Cha SD

  • KMID: 2244544
  • Korean J Gynecol Oncol.
  • 2007 Sep;18(3):165-171.
OBJECTIVE: To evaluate whether mTOR inhibition by rapamycin can enhance the inhibitory effect of sodium butyrate, a histone deacetylase (HDAC) inhibitor on human cervical cancer cell line HeLa. METHODS: Cervical...
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Blockade of the Subthalamo-nigral Pathway Prevents the Motor Component of Pilocarpine Induced Generalized Convulsive Seizure in Rats

Choi JY, Kim HS, Kim YI, Park SM, Lee KS, Kim BS

  • KMID: 2186048
  • J Korean Neurol Assoc.
  • 2000 Mar;18(2):192-198.
BACKGROUND: The substantia nigra pars reticulata is a critical site for the control of epileptic seizures. The potentiation of the inhibitory gamma-amino butyric acid (GABA) ergic input from the striatum...
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Age Specific Reference Values of 24 Plasma Free Amino Acids in Korean Children

Lee KO, Ryu KS, Seo DK, Lee KH

  • KMID: 2135524
  • J Clin Pathol Qual Control.
  • 1998 Jun;20(1):155-162.
BACKGROUND: For early and accurate detection of amino acid disorders, such as inborn error of metabolism, metabolic acidosis, liver disease and kidney disease, establishment of reference value of amino acids...
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Role of Reactive Oxygen Species on Sodium Butyrate Induced Human Hepatocyte Differentiation

Kim TH

BACKGROUND/AIM: Reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion and hydroky radicals are produced in various physiologic and pathologic conditions and involved in many cellular processes as proliferation,...
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DNA-Protein Interaction of gamma-Globin Gene Promoter by Differentiation Inducers

Kim DI, Park JI, Kim IH

  • KMID: 2143367
  • Korean J Hematol.
  • 1999 Aug;34(3):436-444.
BACKGROUND: The K562 erythroleukemia cell line was used to study the molecular mechanisms regulating lineage commitment of hematopoietic cells. There are numerous similarities between the erythroid or megakaryocytic lineages. In...
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Mechanisms of Antiepileptic Drugs

Kim JM

  • KMID: 1816473
  • J Korean Epilepsy Soc.
  • 2000 Dec;4(2):108-118.
Established antiepileptic drugs (AEDs) decrease membrane excitability by interacting with neurotransmitter receptors or ion channels. AEDs developed prior to 1980 appear to act on sodium channels, gamma-amino butyric acid type...
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Anesthesia of a dental patient with Angelman syndrome: A case report

Kim BS, Yeo JS, Kim SO

Angelman syndrome is characterized by a partial deficit of paired autosomal chromosome 15, which contains a subunit of the GABA (Gamma-Amino Butyric Acid) receptor. Many drugs that act on the...
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Dual mechanisms for the regulation of brain-derived neurotrophic factor by valproic acid in neural progenitor cells

Ko HM, Jin Y, Park HH, Lee JH, Jung SH, Choi SY, Lee SH, Shin CY

Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses...
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Augmentation of Sodium Butyrate-induced Apoptosis by Phosphatidylinositol 3-kinase Inhibition in the Human Cervical Cancer Cell-line

Park JK, Cho CH, Ramachandran S, Shin SJ, Kwon SH, Kwon SY, Cha SD

  • KMID: 2270824
  • Cancer Res Treat.
  • 2006 Apr;38(2):112-117.
PURPOSE: Sodium butyrate (NaBT) is principally a histone deacetylase (HDAC) inhibitor, and it has the potential to arrest HPV-positive carcinoma cells at the G1 to S phase transition of the...
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