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Managing Side Effects of Cytotoxic Chemotherapy in Patients With High Grade Gliomas

Ha H, Lim JH

Cytotoxic chemotherapy has been a mainstay of cancer treatment since the 1940s. In the recent era of emergent targeted therapies and immunotherapies, many cytotoxic chemotherapy agents including temozolomide are still...
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Local Drug Delivery Strategies for Glioblastoma Treatment

Cha GD, Jung S, Choi SH, Kim DH

Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason for the limited efficacy of standard treatment is the high recurrence rate of GBM, even after...
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Cerebral Metastases in Appendiceal Cancer: Comprehensive Review and Report of Rare Medullary Carcinoma Histology

Mackel C, Rosenberg H, Varma H, Vega R, Stippler M

Appendiceal cancer is an extremely rare malignancy, and its metastatic spread to the brain is even more unusual. We describe a 47-year-old female who presented with a rare cerebral appendiceal...
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Recent Update on Neurosurgical Management of Brain Metastasis

Yoo J, Park HH, Kang SG, Chang JH

Brain metastasis (BM), classified as a secondary brain tumor, is the most common malignant central nervous system tumor whose median overall survival is approximately 6 months. However, the survival rate...
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Dysembryoplastic Neuroepithelial Tumor: A Benign but Complex Tumor of the Cerebral Cortex

Phi JH, Kim SH

Dysembryoplastic neuroepithelial tumor (DNET) is a distinct type of low-grade glioneuronal tumor. Clinically, DNET is highly associated with intractable epilepsy in young children and adolescents. Therefore, the burden of the...
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Cerebral Microangiopathy Mimicking a High-Grade Glioma in Old Age: A Case Report

Kwon YM, Han SH, Sung KS, Song YJ

Cerebral microangiopathy (CM) has become a common disease related to improved neuroimaging modalities and an increased life expectancy. Intracerebral tumor-like mass lesions have rarely been reported in cases of cerebral...
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Cytomegalovirus-Specific Immunotherapy for Glioblastoma Treatments

Ahn J, Shin C, Kim YS, Park JS, Jeun SS, Ahn S

Over the last two decades, numerous studies have investigated the presence of human cytomegalovirus (CMV) within glioblastoma or gliomas; however, the results are severely conflicting. While a few researchers have...
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Survival Outcomes and Predictors for Recurrence of Surgically Treated Brain Metastasis From Non-Small Cell Lung Cancer

Byun J, Kim JH, Kim M, Lee S, Kim YH, Hong CK, Kim JH

Background There are numerous factors to consider in deciding whether to undergo surgical treatment for brain metastasis from lung cancer. Herein, we aimed to analyze the survival outcome and predictors...
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A Huge Radiation-Induced Cavernous Hemangioma Following Stereotactic Radiosurgery for Meningioma: A Case Report

Lee SH, Kim KH, Lee HJ, Kwon HJ, Choi SW, Kim SH, Koh HS, Youm JY

Radiation-induced cavernous hemangiomas (RICHs) have been increasingly reported as a late complication after conventional radiotherapy. RICH after stereotactic radiosurgery (SRS) is extremely rare and the few cases have been reported...
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Leptomeningeal Spread at the Diagnosis of Glioblastoma Multiforme: A Case Report and Literature Review

Jang C, Cho BK, Hwang SH, Shin HJ, Yoon SH

Approximately two-thirds of glioblastoma (GBM) patients progress to leptomeningeal spread (LMS) within two years. While 90% of LMS cases are diagnosed during the progression and/or recurrence of GBM (defined as...
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