- Lipid A as a Drug Target and Therapeutic Molecule
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Joo SH
- KMID: 2380301
- Biomol Ther.
- 2015 Nov;23(6):510-516.
- doi: 10.4062/biomolther.2015.117
In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway,... -
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- Biosynthetic Pathway of Indole-3-Acetic Acid in Basidiomycetous Yeast Rhodosporidiobolus fluvialis
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Bunsangiam S, Sakpuntoon V, Srisuk N, Ohashi T, Fujiyama K, Limtong S
- KMID: 2470140
- Mycobiology.
- 2019 Sep;47(3):292-300.
- doi: 10.1080/12298093.2019.1638672
IAA biosynthetic pathways in a basidiomycetous yeast, Rhodosporidiobolus fluvialis DMKU-CP293, were investigated. The yeast strain showed tryptophan (Trp)-dependent IAA biosynthesis when grown in tryptophan supplemented mineral salt medium. Gas chromatography–mass... -
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- Streptomyces Cytochrome P450 Enzymes and Their Roles in the Biosynthesis of Macrolide Therapeutic Agents
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Cho MA, Han S, Lim YR, Kim V, Kim H, Kim D
- KMID: 2442003
- Biomol Ther.
- 2019 Feb;27(2):127-133.
- doi: 10.4062/biomolther.2018.183
The study of the genus Streptomyces is of particular interest because it produces a wide array of clinically important bioactive molecules. The genomic sequencing of many Streptomyces species has revealed... -
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- Glycolysis and the Hexosamine Biosynthetic Pathway as Novel Targets for Upper and Lower Airway Inflammation
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Kim YH, Nakayama T, Nayak J
- KMID: 2428844
- Allergy Asthma Immunol Res.
- 2018 Jan;10(1):6-11.
- doi: 10.4168/aair.2018.10.1.6
Glycolysis is a process that rapidly converts glucose to lactate to produce adenosine triphosphate (ATP) under anaerobic conditions and occurs in all eukaryotic and prokaryotic cells. On the other hand,... -
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- A Case of Porphyria with reversible MRI findings
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Kang SY, Ma HI, Kwak KH, Lee SA
- KMID: 2342655
- J Korean Neurol Assoc.
- 1998 Apr;16(2):241-244.
The porphyrias are inherited or acquired disorders of specific enzymes in the heme biosynthetic pathway. Porphyrias have diverse neurologic manifestations with unknown mechanism. Some authors have proposed ischemic vasculopathy... -
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- Acute Intermittent Porphyria and Pregnancy
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Ryu JH, Choi EA, Choi HM, Kim TY, Cho JS, Park YW, Kim JW
- KMID: 1924482
- Korean J Obstet Gynecol.
- 1997 Feb;40(2):414-418.
The Porphyria are a group of inherited and acquired disorders characterized by partial defects in the heme biosynthetic pathway. Among the hepatic forms, acute intermittent porphyria(AIP) is the most severe... -
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- Systematic Analysis of the Anticancer Agent Taxol-Producing Capacity in Colletotrichum Species and Use of the Species for Taxol Production
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Choi J, Park JG, Ali MS, Choi SJ, Baek KH
- KMID: 2328633
- Mycobiology.
- 2016 Jun;44(2):105-111.
- doi: 10.5941/MYCO.2016.44.2.105
Paclitaxel (taxol) has long been used as a potent anticancer agent for the treatment of many cancers. Ever since the fungal species Taxomyces andreanae was first shown to produce taxol... -
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- Severe neurologic manifestations in acute intermittent porphyria developed after spine surgery under general anesthesia: a case report
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Park EY, Kim YS, Lim KJ, Lee HK, Lee SK, Choi H, Kang MH
- KMID: 1966759
- Korean J Anesthesiol.
- 2014 Sep;67(3):217-220.
- doi: 10.4097/kjae.2014.67.3.217
Porphyrias are inherited metabolic disorders resulting from a specific enzyme defect in the heme biosynthetic pathway. Porphyrias are induced by various precipitants. Clinical features include abdominal pain, neurologic manifestations, autonomic... -
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- Convergence of Cancer Metabolism and Immunity: an Overview
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Van Dang C, Kim JW
- KMID: 2400809
- Biomol Ther.
- 2018 Jan;26(1):4-9.
- doi: 10.4062/biomolther.2017.194
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence... -
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- Effect of prostaglandin- and nitric oxide-synthase inhibitors on the lipopolysaccharide-induced adrenomedullin productions in cultured murine macrophage cells
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Koo BS, Won HS, Suh DS, Cho YG, Lee PR, Kim A
- KMID: 1926279
- Korean J Obstet Gynecol.
- 2007 Nov;50(11):1468-1475.
OBJECTIVE: Adrenomedullin (AM), a potent vasorelaxing agent associated with the maintenance of pregnancy, is synthesized in response to inflammation, which is also associated with the biosynthesis of prostaglandin (PG) and... -
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- A Case of Porphyria with Acute Pancreatitis
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Chung SW, Han JH, Ju YM, Yoon KH, Yang WS, Lee SK, Hong SK, hAN EM, Kim BS, Lee KU
- KMID: 1540031
- J Korean Soc Endocrinol.
- 2000 Mar;15(1):128-132.
The porphyrias are a group of disorders caused by deficiency in the enzymes of the heme biosynthetic pathway. Patients with porphyria may develop neurovisceral attacks which include severe abdominal pain,... -
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- Trypanosome Glycosylphosphatidylinositol Biosynthesis
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Hong Y, Kinoshita
- KMID: 1729449
- Korean J Parasitol.
- 2009 Sep;47(3):197-204.
- doi: 10.3347/kjp.2009.47.3.197
Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known... -
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- Effects of Alpha-lipoic Acid on SREBP-1c Expression in HepG2 Cells
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Yun TS, Min AK, Kim NK, Kim MK, Cho HC, Kim HS, Hwang JS, Ryu SY, Park KG, Lee IK
- KMID: 2063547
- J Korean Endocr Soc.
- 2008 Feb;23(1):27-34.
- doi: 10.3803/jkes.2008.23.1.27
BACKGROUND: Non-alcoholic fatty liver disease is common in patients with insulin resistance. Sterol regulatory element binding protein-1c (SREBP-1c) is a member of a family of transcription factors that have been... -
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