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Recent Updates on Acetaminophen Hepatotoxicity: The Role of Nrf2 in Hepatoprotection

Gum SI, Cho MK

  • KMID: 2317831
  • Toxicol Res.
  • 2013 Sep;29(3):165-172.
Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic failure....
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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin

Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS

  • KMID: 2048304
  • Biomol Ther.
  • 2013 Sep;21(5):343-348.
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug...
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The Effects of Phlomis umbrosa Turcz on Osteoclast Differentiation

Baek JM, Park JH, Song JH, Park SN, Jeong WJ, Moon SY, Lee CH, Choi MK, Kim JJ, Oh J, Jang SJ

Many bone-related diseases such as osteoporosis, rheumatoid arthritis are occurred by excessive bone resorbing activity of osteoclasts. Recently, many studies have been proceeded to find out the new therapeutic materials...
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A Novel Compound Rasatiol Isolated from Raphanus sativus Has a Potential to Enhance Extracellular Matrix Synthesis in Dermal Fibroblasts

Roh SS, Park SB, Park SM, Choi BW, Lee MH, Hwang YL, Kim CH, Jeong HA, Kim CD, Lee JH

BACKGROUND: The fibrous proteins of extracellular matrix (ECM) produced by dermal fibroblast contributes to the maintenance of connective tissue integrity. OBJECTIVE: This study is carried out to identify the bioactive ingredient...
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Refractory Plaque Psoriasis Treated with a Combination of Etanercept and Low Dose Methotrexate

Lim HS, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC

  • KMID: 2388395
  • Korean J Dermatol.
  • 2013 Jun;51(6):438-441.
Etanercept has been proven to be highly effective to moderate severe plaque psoriasis. Alternative biologics or combination therapies of etanercept with other systemic agents have been recommended to patients who...
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Investigation into the Use of Complementary and Alternative Medicine and Factors Affecting Use in Korean Patients with Brain Tumors

Shin YS, Lee JA, Bae SH, Lee SY, Jang MK

  • KMID: 2295631
  • J Korean Acad Fundam Nurs.
  • 2013 May;20(2):147-156.
PURPOSE: The study was done to define complementary and alternative medicine (CAM) use among primary brain tumor patients and factors influencing use. METHODS: The study was conducted with convenience sampling in...
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Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream

Chun KS, Kim EH, Lee S, Hahm KB

  • KMID: 2135063
  • Gut Liver.
  • 2013 Mar;7(2):137-149.
Despite substantial progress in screening, early diagnosis, and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic...
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Evaluation of General Toxicity and Genotoxicity of the Silkworm Extract Powder

Heo HS, Choi JH, Oh JJ, Lee WJ, Kim SS, Lee DH, Lee HK, Song SW, Kim KH, Choi YK, Ryu KS, Kang BH

  • KMID: 2317845
  • Toxicol Res.
  • 2013 Dec;29(4):263-278.
The silkworm extract powder contain 1-deoxynojirimycin (DNJ), a potent alpha-glycosidase inhibitor, has therapeutic potency against diabetes mellitus. Therefore, natural products containing DNJ from mulberry leaves and silkworm are consumed as...
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Natural Course of Crohn's Disease and Novel Treatment Drugs

Lee JH, Cheon JH

  • KMID: 2267741
  • Korean J Med.
  • 2013 Dec;85(6):578-585.
Crohn's disease is a chronic recurrent inflammatory disease, mainly affecting the gastrointestinal tract. The pathogenesis of inflammatory bowel disease is believed to be caused by the complex interplay of many...
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Biological Therapy for the Prevention and Treatment of Postoperative Endoscopic Recurrence in Crohn's Disease: Time for Acceptance?

Kotze PG, Saad-Hossne R

In most patients, postoperative endoscopic recurrence (PER) occurs 1 year after abdominal resection for Crohn's disease (CD). Preventing PER is essential for disease control, as most patients develop further clinical...
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Immunologic Evaluation of Drug Allergy

Gomez E, Torres MJ, Mayorga C, Blanca M

Hypersensitivity drug reactions (HDR) consist of an individual abnormal response with the involvement of the immunological system. In addition to specific immunological mechanisms where specific antibodies or sensitised T cells...
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Long Term Treatment Concepts and Proactive Therapy for Atopic Eczema

Wollenberg A, Ehmann LM

Atopic eczema, also known as atopic dermatitis, is a frequent, highly pruritic, chronic skin disease, which is typically running in flares. The traditional treatment mainly consists of the reactive application...
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A Case of Development of Vitiligo Followed by TNF-alpha Antagonist Treatment for Rheumatoid Arthritis

Song R, Kim SM, Lee SH, Lee YA, Hong SJ, Cho HR, Kim GY, Yang HI

As the usage of biologics for rheumatic diseases increases, such as rheumatoid arthritis and ankylosing spondylitis, various cutaneous adverse events are also being increasingly reported. We experienced a case of...
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Developmental Strategy for Stem Cell Therapy Products in Regulatory Considerations

Chang IY, Kim KS

Expectation that stem cell therapy products will prove better and more effective in treating a variety of medical conditions continues to drive expanding research efforts. Stem cell therapy products consist...
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Small Molecule Inhibitors in Rheumatoid Arthritis

Lee EB

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease predominantly affecting diarthroidal joints. Following the successful application of biologic agents, several small molecule inhibitors are currently under clinical trials. Small...
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Targeted Therapy in Inflammatory Bowel Disease; Current Status and Future Perspectives

Jang BI

Novel biologic agents that selectively target specific molecules and pathways have been developed recently for the management of inflammatory bowel disease (IBD). Anti-TNF-alpha, an antibody to TNF-alpha is one of...
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Novel Pharmacologic Therapies in the Treatment of Systemic Lupus Erythematosus

Shim SC

Systemic lupus erythematosus (lupus) is an autoimmune disease that affects primarily women, especially those of reproductive age. Lupus is a prototypic organ non-specific autoimmune disease that may affect any organ...
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Tailored Treatment of Ankylosing Spondylitis

Kim TJ

Ankylosing spondylitis (AS) is a chronic rheumatic disease of the axial skeleton (spine and sacroiliac joints). Only nonsteroidal anti-inflammatory drugs (NSAIDs) and tumor necrosis factor (TNF) alpha inhibitors have currently...
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B Cell Targeted Therapy in Rheumatic Disease

Suh CH

B cells play an important role in the pathogenesis of autoimmune disease. B cells not only produce pathogenic autoantibodies, but also present self-antigens to T cells and provide costimulatory signals...
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Biological Therapy for Inflammatory Bowel Disease in Children

Na SY, Shim JO

  • KMID: 2315314
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2012 Mar;15(1):13-18.
The pathogenesis of inflammatory bowel diseases is not very well understood; it is currently thought to be caused by the interaction between genetic factors, environmental factors, intestinal microbes, and immune...
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