- Biological Therapy for Inflammatory Bowel Disease in Children
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Na SY, Shim JO
- KMID: 2315314
- Pediatr Gastroenterol Hepatol Nutr.
- 2012 Mar;15(1):13-18.
The pathogenesis of inflammatory bowel diseases is not very well understood; it is currently thought to be caused by the interaction between genetic factors, environmental factors, intestinal microbes, and immune... -
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- Developmental Strategy for Stem Cell Therapy Products in Regulatory Considerations
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Chang IY, Kim KS
- KMID: 1436775
- Hanyang Med Rev.
- 2012 Aug;32(3):163-169.
- doi: 10.7599/hmr.2012.32.3.163
Expectation that stem cell therapy products will prove better and more effective in treating a variety of medical conditions continues to drive expanding research efforts. Stem cell therapy products consist... -
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- Biological Therapy for the Prevention and Treatment of Postoperative Endoscopic Recurrence in Crohn's Disease: Time for Acceptance?
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Kotze PG, Saad-Hossne R
- KMID: 2284912
- Intest Res.
- 2013 Oct;11(4):256-260.
- doi: 10.5217/ir.2013.11.4.256
In most patients, postoperative endoscopic recurrence (PER) occurs 1 year after abdominal resection for Crohn's disease (CD). Preventing PER is essential for disease control, as most patients develop further clinical... -
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- Recent advance in tailored treatment of gastric cancer
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Jeung HC, Rha SY
- KMID: 2305795
- Korean J Med.
- 2009 Jul;77(1):1-8.
Even the overall incidence is decreasing and the proportion of early gastric cancer is increasing from the national mass screening program, still gastric cancer is the major issue in Korea.... -
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- Tailored Treatment of Ankylosing Spondylitis
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Kim TJ
- KMID: 2168200
- Hanyang Med Rev.
- 2012 May;32(2):77-82.
- doi: 10.7599/hmr.2012.32.2.77
Ankylosing spondylitis (AS) is a chronic rheumatic disease of the axial skeleton (spine and sacroiliac joints). Only nonsteroidal anti-inflammatory drugs (NSAIDs) and tumor necrosis factor (TNF) alpha inhibitors have currently... -
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- Radiation Induced Lung Damage : Mechanisms and Clinical Implications
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Oh YT
- KMID: 2200066
- J Lung Cancer.
- 2008 Jun;7(1):9-18.
- doi: 10.6058/jlc.2008.7.1.9
Radiation therapy is one of most important therapeutic modalities for thoracic malignancies. However, radiation-induced lung damage, such as radiation pneumonitis or fibrosis, is a main dose-limiting factor when irradiating the... -
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- Novel Pharmacologic Therapies in the Treatment of Systemic Lupus Erythematosus
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Shim SC
- KMID: 2168201
- Hanyang Med Rev.
- 2012 May;32(2):83-93.
- doi: 10.7599/hmr.2012.32.2.83
Systemic lupus erythematosus (lupus) is an autoimmune disease that affects primarily women, especially those of reproductive age. Lupus is a prototypic organ non-specific autoimmune disease that may affect any organ... -
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- Medical treatment of rheumatoid arthritis (I): Nonsteroidal anti-inflammatory drugs, disease modifying antirheumatic drugs and glucocorticoids
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Koh EM
- KMID: 2188412
- J Korean Med Assoc.
- 2010 Oct;53(10):871-879.
- doi: 10.5124/jkma.2010.53.10.871
The medical treatment of rheumatoid arthritis has been dramatically improved with the advances of newer disease-modifying antirheumatic drugs (DMARDs) and biologic agents during previous decades. To prevent joint damage, it... -
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- Natural Course of Crohn's Disease and Novel Treatment Drugs
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Lee JH, Cheon JH
- KMID: 2267741
- Korean J Med.
- 2013 Dec;85(6):578-585.
Crohn's disease is a chronic recurrent inflammatory disease, mainly affecting the gastrointestinal tract. The pathogenesis of inflammatory bowel disease is believed to be caused by the complex interplay of many... -
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- Advances in ulcerative colitis therapy
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Jeen YT, Kim J
- KMID: 2257258
- Korean J Med.
- 2009 Jun;76(6):654-660.
Ulcerative colitis is an idiopathic inflammatory bowel disease characterized by colonic mucosal inflammation and chronic relapsing episodes. The initial therapeutic approach depends on both the extent of colonic involvement and... -
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- Interstitial pneumonitis associated with infliximab therapy in a rheumatoid arthritis patient
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Yoo IS, Song JK
- KMID: 2259128
- Korean J Med.
- 2010 Aug;79(2):215-218.
Tumor necrosis factor (TNF)-alpha inhibitors are well-established biological agents for the treatment of a wide variety of chronic autoimmune diseases and inflammatory conditions, including rheumatoid arthritis (RA), ankylosing spondylitis, and... -
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- Repeated Paradoxical Aggravation of Preexisting Psoriasis during Infliximab Treatment for Crohn's Disease
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Park BC, Lim HJ, Kim BS, Lee WJ, Kim DW, Lee SJ
- KMID: 2172069
- Ann Dermatol.
- 2009 Feb;21(1):60-62.
- doi: 10.5021/ad.2009.21.1.60
As more rheumatologists and dermatologists have begun to use biological agents such as TNF-alpha blocker, they have confronted an unexpected complication: psoriasis was paradoxically aggravated or induced by the TNF-alpha... -
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- B Cell Targeted Therapy in Rheumatic Disease
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Suh CH
- KMID: 2223103
- J Rheum Dis.
- 2012 Apr;19(2):67-72.
- doi: 10.4078/jrd.2012.19.2.67
B cells play an important role in the pathogenesis of autoimmune disease. B cells not only produce pathogenic autoantibodies, but also present self-antigens to T cells and provide costimulatory signals... -
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- Immunologic Evaluation of Drug Allergy
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Gomez E, Torres MJ, Mayorga C, Blanca M
- KMID: 2167043
- Allergy Asthma Immunol Res.
- 2012 Sep;4(5):251-263.
- doi: 10.4168/aair.2012.4.5.251
Hypersensitivity drug reactions (HDR) consist of an individual abnormal response with the involvement of the immunological system. In addition to specific immunological mechanisms where specific antibodies or sensitised T cells... -
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- Targeted Therapy in Inflammatory Bowel Disease; Current Status and Future Perspectives
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Jang BI
- KMID: 2168202
- Hanyang Med Rev.
- 2012 May;32(2):94-102.
- doi: 10.7599/hmr.2012.32.2.94
Novel biologic agents that selectively target specific molecules and pathways have been developed recently for the management of inflammatory bowel disease (IBD). Anti-TNF-alpha, an antibody to TNF-alpha is one of... -
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- Medical treatment of rheumatoid arthritis (II): current biologic agents and newly developing drugs
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Kim J, Song YW
- KMID: 2188413
- J Korean Med Assoc.
- 2010 Oct;53(10):880-888.
- doi: 10.5124/jkma.2010.53.10.880
Disease-modifying antirheumatic drugs (DMARD) have been used to treat rheumatoid arthritis (RA). However, they have limited efficacy and a considerable adverse event profile. Excess production of soluble cytokines, including tumor... -
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- Molecular Imaging of Biological Gene Delivery Vehicles for Targeted Cancer Therapy: Beyond Viral Vectors
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Min JJ, Nguyen VH, Gambhir SS
- KMID: 2051961
- Nucl Med Mol Imaging.
- 2010 Apr;44(1):15-24.
Cancer persists as one of the most devastating diseases in the world. Problems including metastasis and tumor resistance to chemotherapy and radiotherapy have seriously limited the therapeutic effects of present... -
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- Computational Approach for the Analysis of Post-PKS Glycosylation Step
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Kim KB, Park K
- KMID: 2166422
- Genomics Inform.
- 2008 Dec;6(4):223-226.
We introduce a computational approach for analysis of glycosylation in Post-PKS tailoring steps. It is a computational method to predict the deoxysugar biosynthesis unit pathway and the substrate specificity of... -
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- Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream
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Chun KS, Kim EH, Lee S, Hahm KB
- KMID: 2135063
- Gut Liver.
- 2013 Mar;7(2):137-149.
Despite substantial progress in screening, early diagnosis, and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic... -
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- Treatment of Atopic Dermatitis: an Update and Review of the Literature
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Kim TY
- KMID: 1474532
- Pediatr Allergy Respir Dis.
- 2009 Sep;19(3):209-219.
Atopic dermatitis is a chronic, relapsing, inflammatory skin disease, with genetic and environmental backgrounds. Successful management of atopic dermatitis requires a multipronged approach. Management should compromise of a disease-adapted treatment... -
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