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Update on immune checkpoint inhibitors in gynecological cancers

Heong V, Ngoi N, Tan DS

In recent years, progress in our understanding of immune-modulatory signaling pathways in immune cells and the tumor microenvironment (TME) has led to rejuvenated interest in cancer immunotherapy. In particular, immunotherapy...
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Immune-Checkpoint Inhibitors in the Era of Precision Medicine: What Radiologists Should Know

Braschi-Amirfarzan M, Tirumani S, Hodi FS, Nishino M

Over the past five years immune-checkpoint inhibitors have dramatically changed the therapeutic landscape of advanced solid and hematologic malignancies. The currently approved immune-checkpoint inhibitors include antibodies to cytotoxic T-lymphocyte antigen-4,...
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Immune checkpoint blockade therapy for bladder cancer treatment

Kim J

Bladder cancer remains the most immunogenic and expensive malignant tumor in the United States today. As the 4th leading cause of death from cancer in United States, Immunotherapy blocking immune...
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Prognostic value of programmed death-ligand 1 (PD-L1) expression in ovarian clear cell carcinoma

Zhu J, Wen H, Bi R, Wu Y, Wu X

OBJECTIVE: Programmed death-ligand 1 (PD-L1) was expressed in various tumors and antibodies targeting its receptor programmed cell death-1 (PD-1) are emerging cancer therapeutics. This study was designed to evaluate the...
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