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Survival Benefit of Zoledronic Acid in Postmenopausal Breast Cancer Patients Receiving Aromatase Inhibitors

Ahn SG, Kim SH, Lee HM, Lee SA, Jeong J

PURPOSE: A growing body of evidence indicates that zoledronic acid (ZA) can improve the clinical outcome in patients with breast cancer and low estrogen levels. In the present study, we...
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Therapy for idiopathic precocious puberty in children

Shim KS, Kim JT

The incidence of idiopathic precocious puberty is rapidly increasing in Korea. The most common medication used for treatment is a gonadotropin releasing hormone agonist. However, there is some debate regarding...
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Efficacy of Combined Aromatase Inhibitor and Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Metastatic Breast Cancer

Kim SH, Choi J, Park CS, Kim HA, Noh WC, Seong MK

PURPOSE: Endocrine therapy is the preferred treatment for hormone receptor (HR)-positive metastatic breast cancer (MBC). We investigated the efficacy of combined aromatase inhibitor (AI) and luteinizing hormone-releasing hormone (LHRH) agonist...
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Gonadotropin-releasing Hormone Agonist Plus Aromatase Inhibitor in the Treatment of Uterine Leiomyoma in Near Menopause Patient: A Case Series Study

Moradan S

OBJECTIVES: There are many drugs for of symptomatic fibroids. Gonadotropin-releasing hormone (GnRH) agonists are the well known drugs. Also, aromatase inhibitors are effective. All published studies surveyed the effect of...
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Aromatase inhibitor-associated musculoskeletal symptoms: incidence and associated factors

Park JY, Lee SK, Bae SY, Kim J, Kim MK, Kil WH, Lee JE, Nam SJ

  • KMID: 2324873
  • J Korean Surg Soc.
  • 2013 Nov;85(5):205-211.
PURPOSE: Arthralgia is the most common side effect in breast cancer patients receiving aromatase inhibitor (AI) therapy. Few studies have evaluated the risk factors, onset, and incidence of musculoskeletal pain...
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Personalized therapy for advanced breast cancer using molecular signatures

Jung KH

  • KMID: 2305798
  • Korean J Med.
  • 2009 Jul;77(1):26-34.
In Korea, breast cancer is the second common cancer in women and many patients suffer from metastatic disease after surgery and adjuvant therapy. Metastatic breast cancer is unlikely to be...
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Recovery of Ovarian Function with Aromatase Inhibitors: In Young Breast Cancer Patients (<45) with Chemotherapy-induced Amenorrhea

Lee JH, Shin DS, Kim HA, Kim YH, Paik NS, Moon NM, Noh WC

PURPOSE: The role and safety of aromatase inhibitors (AIs) in young breast cancer patients with chemotherapy-induced amenorrhea (CIA) has not been established. The goal of this study was to investigate...
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Pattern Alopecia during Hormonal Anticancer Therapy in Patients with Breast Cancer

Park J, Kim JI, Yun SK, Kim HU, Ihm CW

We report five cases of pattern alopecia in female patients who are undergoing hormonal anticancer therapy for the prevention of recurrence of breast cancer after surgery. Three patients demonstrated male...
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Endocrine Therapy for Breast Cancer

Woo J, Lim W

Breast cancer is the second most common cancer in Korean women and its mortality rate has increased steadily. Although breast cancer is heterogeneous tumor, hormone receptor-positive tumors comprise about 75...
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Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction

Park JY, Chung JH, Lee HC, Lee BI, Park SH, Yoon ES

BACKGROUND: Adjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine...
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The effects of the standardized extracts of Ginkgo biloba on steroidogenesis pathways and aromatase activity in H295R human adrenocortical carcinoma cells

Kim M, Park YJ, Ahn H, Moon B, Chung KH, Oh SM

OBJECTIVES: Aromatase inhibitors that block estrogen synthesis are a proven first-line hormonal therapy for postmenopausal breast cancer. Although it is known that standardized extract of Ginkgo biloba (EGb761) induces anti-carcinogenic...
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Effectiveness of bisphosphonate combined with activated vitamin D in patients with aromatase inhibitor-induced osteoporosis after breast cancer operation

Tanaka M, Itoh S, Takeuchi Y

OBJECTIVES: We compared the effectiveness of bisphosphonates combined with activated vitamin D administered for therapy of aromatase inhibitor-induced osteoporosis after a breast cancer operation and primary postmenopausal osteoporosis through propensity...
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Aromatase inhibitor use is a risk factor of carotid plaque presence in endocrine-responsive breast cancer patients

Seo DH, Cho Y, Lee S, Park S, Kim SI, Park BW, Rhee Y

BACKGROUND/AIMS: The aromatase inhibitors (AIs) are well known anti-hormonal therapy in endocrine-responsive breast cancer patients. It can lead to dyslipidemia and be the risk factor of cardiovascular disease due to...
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Shape-up LUTS/BPH Guideline in Korea: Medical Treatment

Yoo KH, Lee SJ

Benign prostate hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in men older than the middle age, and is a pathologic process that contributes to...
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Adjuvant Hormonal Therapy: Current Standard and Practical Issues

Park BW, Park HS

  • KMID: 2425142
  • J Breast Cancer.
  • 2010 Sep;13(3):242-249.
Adjuvant hormonal therapy is used as the first target-specific approach in curing breast cancers due to its high efficacy and mild side effects. Five years of tamoxifen therapy has been...
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A pilot study of gonadotropin-releasing hormone agonist combined with aromatase inhibitor as fertility-sparing treatment in obese patients with endometrial cancer

Zhang Z, Huang H, Feng F, Wang J, Cheng N

OBJECTIVE: This study aims to evaluate the effects and pregnancy outcomes of gonadotropin-releasing hormone agonist (GnRH agonist) combined with aromatase inhibitor (AI) in preserving the fertility of obese women with...
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Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors

Kim W, Chung Y, Kim SH, Park S, Bae JH, Kim G, Lee SJ, Kim JE, Park BW, Lim SK, Rhee Y

BACKGROUND: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to...
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Medical Treatment of Early Breast Cancer

Kang SB

Breast cancer is one of the most common malignancies among Korean women, with more than 7,000 new cases occurring annually. However, the mortality from breast cancer is decreasing in many western countries,...
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Current Understanding of Endocrine Therapy for Breast Cancer

Park WC

In the treatment of breast cancer, especially in estrogen receptor (ER) positive patients, endocrine therapy has played an important role since bilateral oophorectomy, the first endocrine therapy, was performed by...
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The infertility treatment related with polycystic ovary syndrome

Koo YH, Na YJ

The treatment of infertile women with polycystic ovary syndrome (PCOS) has not yet been established. Before any intervention is initiated, lifestyle modification with diet and exercise leading to weight loss...
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