- Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice
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Nguyen MC, Ryoo S
- KMID: 2371071
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):83-90.
- doi: 10.4196/kjpp.2017.21.1.83
Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the... -
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- Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats
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Oh H, Ahn M, Matsumoto , Taekyun S
- KMID: 1790569
- Korean J Vet Res.
- 2013 Dec;53(4):225-230.
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically... -
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- Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity
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Woo A, Min B, Ryoo S
- KMID: 1104212
- Exp Mol Med.
- 2010 Jul;42(7):524-532.
- doi: 10.3858/emm.2010.42.7.053
Arginase competitively inhibits nitric oxide synthase (NOS) via use of the common substrate L-arginine. Arginase II has recently reported as a novel therapeutic target for the treatment of cardiovascular diseases... -
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- Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase
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Shin W, Cuong TD, Lee JH, Min B, Jeon BH, Lim HK, Ryoo S
- KMID: 1448914
- Korean J Physiol Pharmacol.
- 2011 Jun;15(3):123-128.
- doi: 10.4196/kjpp.2011.15.3.123
Caesalpinia sappan (C. sappan) is a medicinal plant used for promoting blood circulation and removing stasis. During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of... -
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- Endothelial arginase II and atherosclerosis
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Ryoo S, Berkowitz , Lim HK
- KMID: 2092296
- Korean J Anesthesiol.
- 2011 Jul;61(1):3-11.
- doi: 10.4097/kjae.2011.61.1.3
Atherosclerotic vascular disease is the leading cause of morbidity and mortality in developed countries. While it is a complex condition resulting from numerous genetic and environmental factors, it is well... -
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- Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
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Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S
- KMID: 2440020
- Exp Mol Med.
- 2018 Feb;50(2):e438.
- doi: 10.1038/emm.2017.254
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that... -
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- Effect of Taxol on the Function of Murine Microglial Cells
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Chae BM, Kim JM
- KMID: 2010229
- J Korean Neurosurg Soc.
- 1996 Mar;25(3):519-525.
The effect of taxol on the production of nitric oxide(NO) and reactive oxygen radicals(O2- and H2O2)and on the function of phagocytic activity of murine microglial cells were investigated. Stimulated cells... -
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- Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation
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Nguyen MC, Park JT, Jeon YG, Jeon BH, Hoe KL, Kim YM, Lim HK, Ryoo S
- KMID: 2427149
- Yonsei Med J.
- 2016 Nov;57(6):1329-1338.
- doi: 10.3349/ymj.2016.57.6.1329
PURPOSE: Peroxynitrite plays a critical role in vascular pathophysiology by increasing arginase activity and decreasing endothelial nitric oxide synthase (eNOS) activity. Therefore, the aims of this study were to investigate... -
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- Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats
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Shin S, Na S, Kim OS, Choi YS, Kim SH, Oh YJ
- KMID: 2466376
- Yonsei Med J.
- 2016 Jan;57(1):238-246.
- doi: 10.3349/ymj.2016.57.1.238
PURPOSE: Oxidative stress during CO2 pneumoperitoneum is reported to be associated with decreased bioactivity of nitric oxide (NO). However, the changes in endothelial nitric oxide synthase (eNOS), inducible nitric oxide... -
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- Korean Red Ginseng Water Extract Restores Impaired Endothelial Function by Inhibiting Arginase Activity in Aged Mice
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Choi K, Yoon J, Lim HK, Ryoo S
- KMID: 2285497
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):95-101.
- doi: 10.4196/kjpp.2014.18.2.95
Cardiovascular disease is the prime cause of morbidity and mortality and the population ages that may contribute to increase in the occurrence of cardiovascular disease. Arginase upregulation is associated with... -
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- Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
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Shin W, Berkowitz , Ryoo S
- KMID: 1506223
- Exp Mol Med.
- 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that... -
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- Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation
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Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S
- KMID: 2407859
- Yonsei Med J.
- 2018 May;59(3):366-375.
- doi: 10.3349/ymj.2018.59.3.366
PURPOSE: Vascular smooth muscle cell (VSMC) proliferation induced by native low-density lipoprotein (nLDL) stimulation is dependent on superoxide production from activated NADPH oxidase. The present study aimed to investigate whether... -
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- Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy
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Taslimi Y, Zahedifard F, Habibzadeh S, Taheri T, Abbaspour , Sadeghipour A, Mohit E, Rafati S
- KMID: 2176319
- J Breast Cancer.
- 2016 Mar;19(1):34-44.
- doi: 10.4048/jbc.2016.19.1.34
PURPOSE: Immunotherapy is one of the treatment strategies for breast cancer, the most common cancer in women worldwide. In this approach, the patient's immune system is stimulated to attack microscopic... -
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- Successful treatment of a child with citrullinemia
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Lee KH, Park MS, Hahn SH
- KMID: 1963057
- J Genet Med.
- 1997 Sep;1(1):5-10.
The amino acids formed by degradation of proteins ingested produce ammonia. The ammonia which is broken down and excreted as urea through a process known as the Klebs-Hensleit cycle or... -
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- Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges
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Phillips M, Sheaff MT, Szlosarek
- KMID: 2167635
- Cancer Res Treat.
- 2013 Dec;45(4):251-262.
Arginine deprivation is a novel antimetabolite strategy for the treatment of arginine-dependent cancers that exploits differential expression and regulation of key urea cycle enzymes. Several studies have focused on inactivation... -
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- Effects of LHRH Agonist on Erectile Function in the Rabbit
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Choi S, Kim TS, Goldstein
- KMID: 2227029
- Korean J Androl.
- 2003 Dec;21(3):145-151.
PURPOSE: The goal of this study was to investigate the effects of luteinizing hormone-releasing hormone(LHRH) agonist treatment on erectile function in an animal model. MATERIALS AND METHODS: New Zealand White male... -
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- The Effect of Phorbol Myristate Actate on the Synthesis of Nitric Oxide in Murine Microglial Cells
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Rim GN, Kim JM, Chung HT
- KMID: 1955055
- J Korean Neurosurg Soc.
- 1995 Dec;24(12):1455-1462.
In this study, the effect of phorbol ester on the synthesis of nitric oxide(NO) in murine microglial cells was examined. Phorbol 12-myristate 13-acetate(PMA), a protein kinase C(PKC) activator, alone had... -
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- The role of nitric oxide as an effector of macrophage-mediated cytotoxicity against Trichomonas vaginalis
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Park GC, Ryu JS, Min DY
- KMID: 658271
- Korean J Parasitol.
- 1997 Sep;35(3):189-195.
- doi: 10.3347/kjp.1997.35.3.189
The purpose of this study is to determine whether nitric oxide is involved in the extracellular killing of Trichomonas vaginalis by mouse (BALB/c) peritoneal macrophages and RAW264.7 cells... -
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- Nafamostat mesilate promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway
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Choi S, Kwon HJ, Song HJ, Choi SW, Nagar H, Piao S, Jung SB, Jeon BH, Kim DW, Kim CS
- KMID: 2350511
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):539-545.
- doi: 10.4196/kjpp.2016.20.5.539
Nafamostat mesilate (NM), a synthetic serine protease inhibitor, has anticoagulant and anti-inflammatory properties. The intracellular mediator and external anti-inflammatory external signal in the vascular wall have been reported to protect... -
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