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Blockade of intrinsic oscillatory activity of cerebellar Purkinje cells by apamin and nickel

Seo W, Strahlendorf JC, Strahlendorf HK

  • KMID: 1554757
  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):477-484.
Intracellular recordings of oscillatory firing (bursting activity) were obtained from Purkinje cells (PCs) in rat cerebellar slices. Apamin inhibited post-burst hyperpolarizations (PBHs) progressively and finally terminated oscillatory firing activity of PCs. Apamin did...
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Roles of Ca2+ activated K+ conductances on spontaneous firing patterns of isolated rat medial vestibular nucleus neurons

Chun SW, Jun JW, Park BR

  • KMID: 1580629
  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):1-8.
To investigate the contributions of intrinsic membrane properties to the spontaneous activity of medial vestibular nucleus (MVN) neurons, we assessed the effects of blocking large and small calcium-activated potassium channels by means of...
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The characterization of the increase of membrane conductance after depolarization in single rat adrenal chromaffin cells

Lim W, Kim SJ, Kim J

  • KMID: 2071529
  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):95-100.
The conductance change evoked by step depolarization was studied in primarily cultured rat adrenal chromaffin cells using patch-clamp and capacitance measurement techniques. When we applied a depolarizing pulse to a chromaffin cell, the...
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Evaluation of Antifungal Activities of Bee Venom Components Against Malassezia Strains

Kim JH, Park J, Park KK, An HJ, Lee YW

BACKGROUND: Several studies about bee venom components have reported anti-fungal, anti-inflammatory, and anti-cancer effects. Malassezia species are components of skin flora, and also associated with many dermatologic diseases such as...
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Mechanical Hyperalgesia Induced by Blocking Calcium-activated Potassium Channels on Capsaicin-sensitive Afferent Fiber

Lee KH, Shin HK

  • KMID: 2285345
  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):215-219.
Small and large conductance Ca2+-activated K+ (SKCa and BKCa) channels are implicated in the modulation of neuronal excitability. We investigated how changes in peripheral KCa channel activity affect mechanical sensitivity...
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Antifungal Effects of Bee Venom Components on Trichophyton rubrum: A Novel Approach of Bee Venom Study for Possible Emerging Antifungal Agent

Park J, Kwon O, An HJ, Park KK

BACKGROUND: Bee venom (BV) has been widely investigated for potential medical uses. Recent inadvertent uses of BV based products have shown to mitigate signs of fungal infections. However, the component...
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Stationary outward and transient Ca2+-dependent currents in hamster oocytes

Kim YM, Han JH, Kim JS, Hong SG

  • KMID: 1580938
  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):403-408.
The outward currents elicited in hamster eggs by depolarizing pulses were studied. The currents appeared to comprise at least two components, a transient outward component (Ito) and a steady-state outward component (Iinfin). Ito...
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Rhabdomyolysis and Acute Renal Failure Due to Honeybee Stings

Cho YM, Rhew MH, Chin HJ, Lim CS, Ahn CR, Han JS, Kim SG, Lee JS

  • KMID: 2307370
  • Korean J Nephrol.
  • 1998 Jan;17(1):166-169.
Honeybee venom consists of melittin, apamin, phospholipase A2, hyaluronidase and other biologically active substances. It can cause potentially lethal reaction after mass envenomation. But, acute renal failure following multiple bee...
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Physiologic Role of K+ Channels in Relaxation of Rabbit Corpus Cavernosal Tissue

Lee SI, Lee SW

  • KMID: 1894493
  • Korean J Androl.
  • 2002 Dec;20(3):137-142.
PURPOSE: Ion channels play key roles in determining smooth muscle tone by setting the membrane potential and allowing Ca2+ influx. Potassium channels may be important in modulating corporal smooth muscle...
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Role of gap junctions in the endothelium-dependent hyperpolarization of vascular smooth muscle cells

Yamamoto Y, Klemm MF, Hashitani , Lang JR, Soji T, Suzuki H

  • KMID: 1606832
  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):1-8.
Hyperpolarization of arterial smooth muscle by acetylcholine is considered to be produced by the release of an unidentified chemical substance, an endothelium-derived hyperpolarizing factor (EDHF). Several chemicals have been proposed as the candidate...
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Effects of Pharmacological Modulators of Ca2+ -activated K+ Channels on Proliferation of Human Dermal Fibroblast

Yun J, Kim T, Myung S, Bang H, Lim I

  • KMID: 2071626
  • Korean J Physiol Pharmacol.
  • 2006 Apr;10(2):95-99.
Employing electrophysiological and cell proliferation assay techniques, we studied the effects of Ca2+ -activated K+ channel modulators on the proliferation of human dermal fibroblasts, which is important in wound healing....
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Pharmacological evidence that cromakalim inhibits Ca2+ release from intracellular stores in porcine coronary artery

Rhim BY, Hong SH, Kim CD, Lee WS, Hong KW

  • KMID: 2285155
  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):27-34.
In the present study, it was aimed to further identify the intracellular action mechanism of cromakalim and levcromakaliin in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine...
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The effect of sodium nitroprusside on muscle tension in guinea-pig ileum

Kwon SC, Kim SY, Kim EJ, Kang BS

  • KMID: 2285198
  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):797-808.
Nitric oxide (NO) has been known as a mediator of nonadrenergic, noncholinergic inhibitory neurotransmitter in intestinal smooth muscles. It has been suggested that NO donor such as sodium nitroprusside (SNP) produces relaxation of...
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Possible Involvement of Ca2+ Activated K+ Channels, SK Channel, in the Quercetin-Induced Vasodilatation

Nishida S, Satoh H

Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca2+ activated K+ (KCa)...
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Isolation of Voltage Dependent Calcium Current in Chick Inner Hair Cell

Lee SH, Shin MC, Ahn TH, Kim KY, Kim K, Min HJ, Park CW

BACKGROUND AND OBJECTIVES: Voltage dependent calcium channel (VDCC) mediates calcium ion influx and controls neurotransmitter release in excitable cells. Hair cells in vertebrates cochlea are known to express L-type VDCC....
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Mechanism of L-NAME-resistant endothelium-dependent relaxation induced by acetylcholine in rabbit renal artery

Yeon DS, Ahn DS, Lee YH, Kwon SC

  • KMID: 1581025
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):471-477.
In the rabbit renal artery, acetylcholine (ACh, 1 nM ~ 10 micrometer) induced endothelium-dependent relaxation of arterial rings precontracted with norepinephrine (NE, 1 micrometer) in a dose-dependent manner. NG-nitro-L-arginine (L-NAME, 0.1 mM), an...
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Effects of PCLS-2 in Regulation of Rabbit Corpus Cavernosum Smooth Muscle Tone

Park JK, Kim JU, Cho KW, Lee SK, Kim YC, Lee HS

  • KMID: 2292366
  • Korean J Urol.
  • 2001 Feb;42(2):159-165.
PURPOSE: Relaxation of the penile cavernosum smooth muscle is a critical event in erection. Artemisia iwaymogi(AI) is a perennial herb growing in Korea. The aerial parts have been used in...
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Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon

Jiao HY, Kim DH, Ki JS, Ryu KH, Choi S, Jun JY

Lubiprostone is a chloride (Cl-) channel activator derived from prostaglandin E1 and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal...
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Modulation of outward potassium currents by nitric oxide in longitudinal smooth muscle cells of guinea-pig ileum

Kwon SC, Rim SJ, Kang BS

  • KMID: 1562325
  • Korean J Physiol Pharmacol.
  • 1998 Apr;2(2):225-232.
To investigate the possible involvement of outward potassium (K+) currents in nitric oxide-induced relaxation in intestinal smooth muscle, we used whole-cell patch clamp technique in freshly dispersed guinea-pig ileum longitudinal smooth muscle cells....
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Ionic mechanisms underlying spontaneous firing in isolated type B medial vestibular nucleus neurons

Chun SW, Choi JH, Kim KS, Lee HJ, Kim SR, Lee MY, Park BR

  • KMID: 2328980
  • J Korean Bal Soc.
  • 2003 Jun;2(1):78-85.
Medial vestibular nucleus (MVN) neurons are found to have spontaneous electrical activity in the absence of any detectable synaptic input. To investigate the contributions of intrinsic mechanisms to the spontaneous...
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