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Hereditary Spherocytosis

Park ES

  • KMID: 2049272
  • Clin Pediatr Hematol Oncol.
  • 2012 Oct;19(2):57-63.
Hereditary spherocytosis is a hemolytic anemia caused by erythrocyte membrane deficiencies that lead to membrane destabilization and vesiculation. Abnormal spherocytes are trapped and destroyed in the spleen. Mutations in several...
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Abnormalities of erythrocyte membrane proteins in Korean patients with hereditary spherocytosis

Lee YK, Cho HI, Park SS, Lee YJ, Ra E, Chang YH, Hur M, Shin HY, Ahn HS

Hereditary spherocytosis (HS) is a common inherited erythrocyte membrane disorder characterized by chronic hemolytic anemia. Clinical manifestations and biochemical abnormalities of HS are heterogeneous. In this study, we investigated erythrocyte...
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Association Study of ANK3 Polymorphism and Risk of Schizophrenia

Yang SY, Huh IS, Cho EY, Choi MJ, Park T, Lee YS, Hong KS

OBJECTIVES: Previous genome-wide association studies have indicated the association between ankyrin 3 (ANK3) and the vulnerability of schizophrenia. We investigated the association between single nucleotide polymorphisms (SNPs) covering the whole...
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Antipruritic effect of curcumin on histamine-induced itching in mice

Lee HK, Park SB, Chang SY, Jung SJ

Itching is a common clinical symptom of skin disease that significantly affects a patient's quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers...
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Purification of Band 3 from the Human Erythrocyte Membrane and its Incorporation into Liposome

Kim JR, Kim JH, Lee KY

Band 3, the predominant 95,000 dalton anion transport protein, is the major intrinsic glycoprotein of the human erythrocyte membrane. This anion carrier exists as a dimer and binds the cytoskeletons...
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Involvement of TRPA1 in the cinnamaldehyde-induced pulpal blood flow change in the feline dental pulp

Kim D, Lee MH, Kim SK

OBJECTIVES: The purpose of this study was to investigate the involvement of TRPA1 in the cinnamaldehyde-induced pulpal blood flow (PBF) change in the feline dental pulp. MATERIALS AND METHODS: Mandibles of...
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Effects of Nefopam on Streptozotocin-Induced Diabetic Neuropathic Pain in Rats

Nam JS, Cheong YS, Karm MH, Ahn HS, Sim JH, Kim JS, Choi SS, Leem JG

BACKGROUND: Nefopam is a centrally acting non-opioid analgesic agent. Its analgesic properties may be related to the inhibitions of monoamine reuptake and the N-methyl-D-aspartate (NMDA) receptor. The antinociceptive effect of...
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The Expression of Cardiac Ankyrin Repeat Protein in an Animal Model of Adriamycin-Induced Cardiomyopathy

Chung WB, Youn HJ, Choi YS, Park CS, Oh YS, Chung WS, Kim JH, Lee EH

BACKGROUND AND OBJECTIVES: Cardiac ankyrin repeat protein (CARP) is an embryonic nuclear protein, and its expression is increased under conditions of pressure or volume overload and also in the failing...
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SDS-PAGE Analysis of Red Cell Membrane Proteins in Hereditary Hemolytic Anemia

Lee YK, Cho HI, Park SS, Ra E, Chang YH, Hur M, Lee YJ, Shin HY, Ahn HS

  • KMID: 1533972
  • Korean J Hematol.
  • 1999 Nov;34(4):559-567.
BACKGROUND: Red cell membrane is a lipid bilayer laminated by the membrane cytoskeleton at the surface of inner monolayer. A class of hemolytic anemia, such as hereditary spherocytosis (HS) or...
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Vagal Transient Receptor Potential Ankyrin 1 Mediates Stress-exacerbated Visceral Mechanonociception After Antral Cold Exposure

Chen X, Luo Q, Yan X, Li W, Chen S

  • KMID: 2454643
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):442-460.
  • doi: 10.5056/jnm19014
BACKGROUND/AIMS: Abdominal pain can be evoked or exacerbated after gastrointestinal cold stimulation in some patients with diarrhea-predominant irritable bowel syndrome (IBS-D), indicating a low temperature-induced sensitization of visceral perception. We...
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Erythrocyte Membrane Protein Alterations by SDS-PAGE and Underlying Clinical Heterogeneity in Hereditary Spherocytosis

Yoo ES, Choi HS, Shin HY, Ahn HS, Lee YK, Cho HI

  • KMID: 1979968
  • Korean J Pediatr Hematol Oncol.
  • 1997 Oct;4(2):261-272.
BACKGROUND: Hereditary spherocytosis(HS) is a clinically and biochemically very heterogeneous disorder The purpose of this study is to detect erythrocyte membrane protein abnormalities by SDS-PAGE and to investigate the frequency...
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A case of concomitant Gilbert's syndrome and hereditary spherocytosis

Lee HJ, Moon HS, Lee ES, Kim SH, Sung JK, Lee BS, Jeong HY, Lee HY, Eu YJ

We describe moderate hyperbilirubinemia in a 28-year-old man who suffered from gallstones and splenomegaly, with combined disorders of hereditary spherocytosis (HS) and Gilbert's syndrome (GS). Since it is difficult to...
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