Korean J Biol Psychiatry.  2015 Nov;22(4):173-178. 10.0000/kjbp.2015.22.4.173.

Association Study of ANK3 Polymorphism and Risk of Schizophrenia

• Yang SY
• Huh IS
• Cho EY
• Choi MJ
• Park T
• Lee YS
• Hong KS

• KMID: 2251061
• DOI: http://doi.org/10.0000/kjbp.2015.22.4.173

Abstract

OBJECTIVES
Previous genome-wide association studies have indicated the association between ankyrin 3 (ANK3) and the vulnerability of schizophrenia. We investigated the association between single nucleotide polymorphisms (SNPs) covering the whole ANK3 locus and schizophrenia in the Korean population.
METHODS
The study subjects were 582 patients with schizophrenia and 502 healthy controls. Thirty-eight tag SNPs on ANK3 and five additional SNPs showing significant association with schizophrenia in previous studies were genotyped.
RESULTS
Three (rs10994181, rs16914791, rs1938526) of 43 SNPs showed a nominally significant association (p < 0.05) with at least one genotype model. But none of these associations remained significant after adjusting for multiple testing errors with Bonferroni's correction.
CONCLUSIONS
We could not identify a significant association between ANK3 and schizophrenia in the Korean population. However, three SNPs showing an association signal with nominal significance need to be investigated in future studies with higher statistical power and more specific phenotype crossing the current diagnostic categories.

Keyword

ANK3; Schizophrenia; Genetic association study

MeSH Terms

Ankyrins
Genetic Association Studies
Genome-Wide Association Study
Genotype
Humans
Phenotype
Polymorphism, Single Nucleotide
Schizophrenia*
Ankyrins