- Increased aldose reductase activity of cultured endothelial cell inhigh glucose media and reserve by epalrestat
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Na SY, Woo JT, Kim JW, Kim KW, Kim YS, Choi YK, Seo KS, Paeng JR
- KMID: 1700009
- J Korean Diabetes Assoc.
- 1992 Mar;16(1):17-23.
No abstract available. -
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- Aldose Reductase Inhibitory Alkaloids from Corydalis ternata
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Seo W, Jung SH, Shim SH
- KMID: 2328874
- Nat Prod Sci.
- 2016 Jun;22(2):102-106.
- doi: 10.20307/nps.2016.22.2.102
A methanolic extract of Corydalis ternata having aldose reductase inhibitory activity was examined as a possible aldose reductase (ALR2) inhibitor, a key enzyme involved in diabetic complications. Seven alkaloids, tetrahydrocoptisine... -
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- Esculetin, a Coumarin Derivative, Inhibits Aldose Reductase Activity in vitro and Cataractogenesis in Galactose-Fed Rats
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Kim CS, Kim J, Lee YM, Sohn E, Kim JS
- KMID: 2170530
- Biomol Ther.
- 2016 Mar;24(2):178-183.
- doi: 10.4062/biomolther.2015.101
Naturally occurring coumarin compounds have received substantial attention due to their pharmaceutical effects. Esculetin is a coumarin derivative and a polyphenol compound that is used in a variety of therapeutic... -
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- Assessment and Significance of RBC-Sorbitol Level on Diabetic Retinopathy
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Ji JY, Lee JH, Chang MH
- KMID: 2336640
- J Korean Ophthalmol Soc.
- 1998 Jan;39(1):98-103.
The intracellular accumulation of sorbitol, a product, which arises from polyol pathway: one of glucose metabolic pathways, has been said to be one of the pathogens for diabetic retinopathy. So,... -
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- Effects of oxidative stress on the expression of aldose reductase in vascular smooth muscle cells
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Kim HJ, Chang KC, Seo HG
- KMID: 1606950
- Korean J Physiol Pharmacol.
- 2001 Jun;5(3):271-278.
Oxidative stress and methylglyoxal (MG), a reactive dicarbonyl metabolites produced by enzymatic and non-enzymatic reaction of normal metabolism, induced aldose reductase (AR) expression in rat aortic smooth muscle cells (SMC). AR expression was... -
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- Upregulation of Aldose Reductase mRNA by Hyperglycemia in Claf Pulmonary Artery Endothelial Cells
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Nam SY, Oh JH, Park JC, Yoon JS, Won KC, Lee CW, Cho IH, Lee CK, Lee IK, Lee HW
- KMID: 2331671
- J Korean Diabetes Assoc.
- 1998 Sep;22(3):290-298.
BACKGROUND: Hyperglycemia is thought to be an important etiologic factor in the development of diabetic macro- and microangiopathies. Several theories have been proposed to explain why diabetic patients are at... -
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- Antioxidative and aldose reductase-inhibitory effects of a fermentation filtrate of Rubus coreanus
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Kwon SC, Kim YB
- KMID: 1444973
- Lab Anim Res.
- 2011 Dec;27(4):365-368.
- doi: 10.5625/lar.2011.27.4.365
Antioxidative and aldose reductase (AR)-inhibitory effects of a fermentation filtrate of Rubus coreanus (FRC) were investigated using corneal/retinal homogenate and lens cytosol, respectively. Rat corneal/retinal homogenate was treated with 50... -
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- Pathogenesis of diabetic nephropathy
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Park JT, Kang SW
- KMID: 2305774
- Korean J Med.
- 2009 Dec;77(6):670-677.
Diabetic nephropathy, the leading cause of end stage renal disease in many countries, is pathologically characterized by glomerular and tubular hypertrophy, extracellular matrix accumulation, inflammatory cell infiltration, and podocytopenia associated... -
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- Alternative Isoforms of TonEBP with Variable N-termini are Expressed in Mammalian Cells
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Kim HS, Son SJ, Kim SN, Kim YD, Kim KJ, Jeon BH, Park JB, Lee SD
- KMID: 2285337
- Korean J Physiol Pharmacol.
- 2007 Jun;11(3):135-138.
Hypertonicity imposes a great deal of stress to cells since it causes rise in cellular ionic strength, which can be reduced by the accumulation of compatible osmolytes. TonEBP plays a... -
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- Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat
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Li X, Shen Y, Lu Y, Yang J
- KMID: 2285584
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):401-411.
- doi: 10.4196/kjpp.2015.19.5.401
Aldose reductase (AR) is known to play a crucial role in the mediation of diabetic and cardiovascular complications. Recently, several studies have demonstrated that allergen-induced airway remodeling and ovalbumin-induced asthma... -
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- TonEBP and SMIT expression in human placenta
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Shin JA, Kwon HM, Han KH, Lee HY
- KMID: 2046742
- Anat Cell Biol.
- 2012 Sep;45(3):155-159.
- doi: 10.5115/acb.2012.45.3.155
Tonicity-responsive enhancer binding protein (TonEBP) is a signal transcription factor of transporters such as sodium-myo-inositol cotransporter (SMIT), aldose reductase. TonEBP has a variety of functions such as control of intracellular... -
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- The Association of Aldose Reductase Gene Polymorphisms with Neuropathy in Patients with Type 2 Diabetes
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Jeong IK, Park KS, Moon MK, Kim JH, Shin CS, Kim SY, Lee HK
- KMID: 1523016
- J Korean Diabetes Assoc.
- 2007 May;31(3):274-283.
- doi: 10.4093/jkda.2007.31.3.274
BACKGROUND: Previous studies have suggested that polymorphisms in and around the aldose reductase (AR) gene are associated with the development of diabetic microvascular disease. This study explored the hypothesis that... -
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- Mechanism of Developing Diabetic Vascular Complication by Oxidative Stress
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Kim BH, Son SM
- KMID: 2391899
- J Korean Endocr Soc.
- 2006 Dec;21(6):448-459.
Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in the patients with diabetes mellitus. Oxidative stress has been postulated to be a major contributor to... -
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- High Expression of Aldo-Keto Reductase 1B10 Is an Independent Predictor of Favorable Prognosis in Patients with Hepatocellular Carcinoma
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Ha SY, Song DH, Lee JJ, Lee HW, Cho SY, Park CK
- KMID: 2070083
- Gut Liver.
- 2014 Nov;8(6):648-654.
- doi: 10.5009/gnl13406
BACKGROUND/AIMS: Upregulation of aldo-keto reductase 1B10 (AKR1B10) through the mitogenic activator protein-1 signaling pathway might promote hepatocarcinogenesis and tumor progression. The goal of this study was to evaluate the prognostic... -
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- Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage
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Cho SB, Eum WS, Shin MJ, Kwon HJ, Park JH, Choi YJ, Park J, Han KH, Kang JH, Kim DS, Cho SW, Kim DW, Choi SY
- KMID: 2463716
- Exp Neurobiol.
- 2019 Oct;28(5):612-627.
- doi: 10.5607/en.2019.28.5.612
Aldose reductase (AR) protein, a member of the NADPH-dependent aldo-keto reductase family, reduces a wide range of aldehydes and enhances cell survival by inhibition of oxidative stress. Oxidative stress is... -
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- The Abundance and Nuclear Distribution of TonEBP in Response to Changes of Tonicity in Hyperglycemic Cells
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Park WK
- KMID: 1515286
- J Korean Soc Endocrinol.
- 2004 Oct;19(5):501-510.
BACKGROUND: TonEBP (Tonicity-responsive enhancer binding protein) regulates the transcription of tonicity responsive genes, such as sodium-myo-inositol and the sodium- chloride-betaine co- transporters (SMIT & BGT1), heat shock protein 70 (HSP70)... -
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- High Glucose Potentiates PC12 Cell Apoptosis Induced by Hypoxia through Reactive Oxygen Species
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Byun JS, Lee SH, Lee KY
- KMID: 2116751
- Chonnam Med J.
- 2002 Jun;38(2):83-88.
Diabetic hyperglycemia increases brain damage after cerebral ischemia, although the underlining mechanisms remain unclear. Some experimental evidences of the high glucose effects on the cell death were shown on the... -
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- Alteration of Hypertonic Responses in Hyperglycemic Human Retinal Pigment Epithelial and Placental Cells
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Park WK
- KMID: 1575478
- J Korean Diabetes Assoc.
- 2004 Jun;28(3):164-176.
BACKGROUND: In mammals, cellular protection from hypertonic damage is achieved by increasing the expression of genes, such as aldose reductase(AR) and Na+/myo-inositol transporter(SMIT). Recent studies have revealed that tonicityresponsive enhancer... -
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- Effect of High Glucose on Nitric Oxide Production in Culteured Rat Mesangial Cells
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Noh HJ, Ha HJ, Yoo MR, Shin SK, Song HY, Hwang JH, Kang SW, Choi KH, Han DS, Lee HY
- KMID: 2307276
- Korean J Nephrol.
- 1999 Nov;18(6):856-868.
Diabetic nephopathy is one of the leading causes of end-stage renal disease and characterized pathologically by the glomerular mesangial expansion and increased extracellular matrix(ECM) formation. Glomerular hyper-filtration and increased vascular... -
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- Identification of Proteins Differentially Expressed in the Conventional Renal Cell Carcinoma by Proteomic Analysis
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Hwa JS, Park HJ, Jung JH, Kam SC, Park HC, Kim CW, Kang KR, Hyun JS, Chung KH
- KMID: 1778505
- J Korean Med Sci.
- 2005 Jun;20(3):450-455.
- doi: 10.3346/jkms.2005.20.3.450
Renal cell carcinoma (RCC) is one of the most malignant tumors in urology, and due to its insidious onset patients frequently have advanced disease at the time of clinical presentation.... -
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