- Quantitative Analysis of Agmatine by HPLC in Ischemic Brain
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Hong JS, Chun H, Jeong HS, Kim JH, Lee WT, Park KA, Lee JE
- KMID: 1610757
- Korean J Anat.
- 2003 Aug;36(4):257-264.
Agmatine, a widely distributed molecule in mammalian tissues, shows neuroprotective effects in brain ischemia. We describe the neuroprotective effects of agmatine in the mouse MCAO model and the quantitative change... -
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- The Effect of Agmatine on Expression of MMP2 and MMP9 in Cerebral Ischemia
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Kim JH, Lee YW, Kim JY, Lee WT, Park KA, Lee JE
- KMID: 2092923
- Korean J Anat.
- 2008 Mar;41(1):97-104.
Agmatine is a primary amine formed by decarboxylation of L-arginine synthesized in the mammalian brain. Recent studies have shown that agmatine is neuroprotective in models of trauma and ischemia. The... -
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- Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling
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Song J, Lee B, Kang S, Oh Y, Kim E, Kim CH, Song HT, Lee JE
- KMID: 2165575
- Exp Neurobiol.
- 2016 Feb;25(1):24-32.
- doi: 10.5607/en.2016.25.1.24
Neuronal senescence caused by diabetic neuropathy is considered a common complication of diabetes mellitus. Neuronal senescence leads to the secretion of pro-inflammatory cytokines, the production of reactive oxygen species, and... -
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- Endogenous Agmatine Induced by Ischemic Preconditioning Regulates Ischemic Tolerance Following Cerebral Ischemia
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Kim JH, Kim JY, Jung JY, Lee YW, Lee WT, Huh SK, Lee JE
- KMID: 2398426
- Exp Neurobiol.
- 2017 Dec;26(6):380-389.
- doi: 10.5607/en.2017.26.6.380
Ischemic preconditioning (IP) is one of the most important endogenous mechanisms that protect the cells against ischemia-reperfusion (I/R) injury. However, the exact molecular mechanisms remain unclear. In this study, we... -
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- Suppression of MicroRNA let-7a Expression by Agmatine Regulates Neural Stem Cell Differentiation
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Song J, Oh Y, Kim JY, Cho KJ, Lee JE
- KMID: 2427165
- Yonsei Med J.
- 2016 Nov;57(6):1461-1467.
- doi: 10.3349/ymj.2016.57.6.1461
PURPOSE: Neural stem cells (NSCs) effectively reverse some severe central nervous system (CNS) disorders, due to their ability to differentiate into neurons. Agmatine, a biogenic amine, has cellular protective effects... -
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- Agmatine Modulates the Phenotype of Macrophage Acute Phase after Spinal Cord Injury in Rats
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Kim JH, Kim JY, Mun CH, Suh M, Lee JE
- KMID: 2398432
- Exp Neurobiol.
- 2017 Oct;26(5):278-286.
- doi: 10.5607/en.2017.26.5.278
Agmatine is a decarboxylated arginine by arginine decarboxylase. Agmatine is known to be a neuroprotective agent. It has been reported that agmatine works as a NMDA receptor blocker or a... -
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- Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain
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Mun CH, Lee WT, Park KA, Lee JE
- KMID: 2168878
- Anat Cell Biol.
- 2010 Sep;43(3):230-240.
- doi: 10.5115/acb.2010.43.3.230
Nitric oxide (NO) production by endothelial nitric oxide synthase (eNOS) plays a protective role in cerebral ischemia by maintaining vascular permeability, whereas NO derived from neuronal and inducible NOS is... -
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- Role of Agmatine on Neuroglia in Central Nervous System Injury
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Barua S, Kim JY, Lee JE
- KMID: 2469632
- Brain Neurorehabil.
- 2019 Mar;12(1):e2.
- doi: 10.12786/bn.2019.12.e2
Recovery from central nervous system (CNS) injury, such as stroke or spinal cord injury (SCI), largely depends on axonal regeneration, and the neuronal and glial cells plasticity in the lesioned... -
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- Effects of Intra-articular Injection of Agmatine and Clonidine into the Knee Joint Cavity on the Induction and Maintenance of Arthritic Pain in Rats
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Lee MJ, Shim HS, Seol GH, Kim PJ, Han SH, Yee J, Kim C, Lee KC, Kim HY, Min SS
- KMID: 1763522
- Korean J Anesthesiol.
- 2008 Jun;54(6):656-661.
- doi: 10.4097/kjae.2008.54.6.656
BACKGROUND: Previous studies suggest that systemic administration of agmatine, endogenous ligand for imidazoline receptors has anti-hypernociceptive effects in experimental animal. However the peripheral effects of agmatine on inflammatory pain have... -
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- Agmatine Attenuates Nitric Oxide Synthesis and Protects ER-structure from Global Cerebral Ischemia in Rats
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Mun CH, Kim JH, Park KA, Lee WT, Baik JH, Lee JE
- KMID: 1472487
- Korean J Anat.
- 2009 Sep;42(3):149-160.
In ischemic strokes, apoptosis is caused by excitotoxicity, ionic imbalance, oxidative/nitrosative stress, and apoptotic-like pathways. Nitric oxide (NO), a free radical, is elevated after ischemic insult. NO, which is generated... -
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- Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury
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Kim JY, Lee YW, Kim JH, Lee WT, Park KA, Lee JE
- KMID: 2164481
- J Korean Med Sci.
- 2015 Jul;30(7):943-952.
- doi: 10.3346/jkms.2015.30.7.943
Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after... -
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- Recovered changes in the spleen by agmatine treatment after transient cerebral ischemia
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Uranchimeg D, Kim JH, Kim JY, Lee WT, Park KA, Batbaatar , Tundevrentsen S, Amgalanbaatar D, Lee JE
- KMID: 2168896
- Anat Cell Biol.
- 2010 Mar;43(1):44-53.
- doi: 10.5115/acb.2010.43.1.44
Stroke or cerebrovascular injury is the leading cause of disability and the third leading cause of deaths worldwide. After the initial ischemic injury, sympathetic signals are transmitted to the spleen... -
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- The Effects of Agmatine on Apoptosis Induced by Capsaicin in Mouse Hippocampal Neuron
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Lee SH, Oh SH, Park KA, Lee WT, Lee JE
- KMID: 2224535
- Korean J Anat.
- 2000 Dec;33(6):733-742.
Capsaicin, the pungent algesic substance of the red pepper is known to be a neurotoxic substance, interrupting the pain conducting pathway. Until recently the neurotoxic effects of capsaicin in adult... -
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- Effects of Agmatine on GABAA Receptor Antagonist-induced Tactile Allodynia
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Lee YW, Ishikawa T
- KMID: 1978704
- Korean J Pain.
- 2008 Dec;21(3):173-178.
- doi: 10.3344/kjp.2008.21.3.173
BACKGROUND: The intrathecal (IT) GABAA receptor antagonist, bicuculline (BIC), results in tactile allodynia (TA) through disinhibition in the spinal cord. Such disinhibition is considered to be an important mechanism for... -
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- Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
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Dejanovic , Stevanovic I, Ninkovic M, Stojanovic I, Lavrnja I, Radicevic , Pavlovic M
- KMID: 2363335
- J Vet Sci.
- 2016 Mar;17(1):53-61.
- doi: 10.4142/jvs.2016.17.1.53
This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen... -
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- The Effect of Agmatine on Expression of IL-1beta and TLX Which Promotes Neuronal Differentiation in Lipopolysaccharide-Treated Neural Progenitors
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Song J, Kumar BK, Kang S, Park KA, Lee WT, Lee JE
- KMID: 2284630
- Exp Neurobiol.
- 2013 Dec;22(4):268-276.
- doi: 10.5607/en.2013.22.4.268
Differentiation of neural progenitor cells (NPCs) is important for protecting neural cells and brain tissue during inflammation. Interleukin-1 beta (IL-1beta) is the most common pro- inflammatory cytokine in brain inflammation,... -
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- Agmatine Improves Cognitive Dysfunction and Prevents Cell Death in a Streptozotocin-Induced Alzheimer Rat Model
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Song J, Hur BE, Bokara KK, Yang W, Cho HJ, Park KA, Lee WT, Lee KM, Lee JE
- KMID: 2068679
- Yonsei Med J.
- 2014 May;55(3):689-699.
- doi: 10.3349/ymj.2014.55.3.689
PURPOSE: Alzheimer's disease (AD) results in memory impairment and neuronal cell death in the brain. Previous studies demonstrated that intracerebroventricular administration of streptozotocin (STZ) induces pathological and behavioral alterations similar... -
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- Virulence genes of Streptococcus mutans and dental caries
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You YO
- KMID: 2452744
- Int J Oral Biol.
- 2019 Jun;44(2):31-36.
- doi: 10.11620/IJOB.2019.44.2.31
Streptococcus mutans is one of the important bacteria that forms dental biofilm and cause dental caries. Virulence genes in S. mutans can be classified into the genes involved in bacterial... -
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