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Amplification of c-erbB-2 proto-oncogene in cancer foci, adjacent normal, metastatic and normal tissues of human primary gastric adenocarcinomas

Kim JS, Choi CW, Kim BS, Shin SW, Kim YH, Mok YJ, Kim JS, Koo BH

Genetic damages are frequently found in both tumor and normal cells at carcinogen exposed areas in the patients with upper aerodigestive tract cancer. These phenomena are explained by the...
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DNA ploidy patterns in gastric adenocarcinoma

Kim JY, Cho HJ

To assess the value of DNA ploidy, flow cytometric analysis was performed on unfixed fresh materials obtained from 86 patients with gastric cancer who underwent stomach resection. We evaluated the...
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Colorectal adenocarcinoma as a second malignant neoplasm following rhabdomyosarcoma of the urinary bladder: a case report

Park SS, Kim BK, Kim CJ, Kim WS, Kim IO, Park KW, Shin HY, Ahn HS

Following improvements in therapy for childhood malignancies, the striking increase in survival rate over the past 30 years has led to the increase risk of developing second malignant neoplasms (SMNs)....
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Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma

Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES

BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such...
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Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

Hong YS, Chang JH, Kwon OJ, Ham YA, Choi JH

  • KMID: 755008
  • Exp Mol Med.
  • 1998 Dec;30(4):192-198.
The levels of expressions and catalytic activities of cytochrome P450 (CYP1A1) and glutathione-S-transferase class mu (GSTM1) enzymes in lungs and their metabolic balance may be an important determinant host factor underlying lung cancer....
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Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers

Kim JR, Kim SY, Kim MJ, Kim JH

  • KMID: 754996
  • Exp Mol Med.
  • 1998 Jun;30(2):109-114.
The CDKN2 (MTS1/p16INK4A) gene, encoding cyclin dependent kinase inhibitor, was found to be homozygously deleted at a high frequency in cell lines from many different types of cancer and some primary cancers....
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Loss of heterozygosity on chromosome XP22.2-p22.13 and Xq26.1-q27.1 in human breast carcinomas

Choi C, Kim MH, Juhng SW

In an attempt to investigate the X chromosome harboring putative tumor suppressor genes (TSGs) in sporadic breast carcinoma, we performed loss of heterozygosity (LOH) studies on 23 breast carcinomas...
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Growth and Invasion of Sporadic Colorectal Adenocarcinomas in Terms of Genetic Change

Roh SA, Choi EY, Cho DH, Jang SJ, Kim SY, Kim YS, Kim JC

Integrative genetic changes were examined in relation to tumor growth and progression of sporadic colorectal cancers. Ninety-two sporadic colorectal cancer patients and 12 human colorectal cancer cell lines were evaluated....
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Microsatellite instability in Korean patients with gastric adenocarcinoma

Jee MS, Koo C, Kim MH, Choi C, Lee KM, Choi SK, Rew JS, Yoon CM

  • KMID: 1051579
  • Korean J Intern Med.
  • 1997 Jun;12(2):144-154.
OBJECTIVES: Microsatellites are short repeated oligonucleotide sequences found throughout the human genome. High mutation rates in microsatellite sequences have been found in tumors from patients with hereditary non-polyposis colorectal carcinoma...
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In vivo Recombinant Adenovirus-mediated p53 Gene Therapy in a Syngeneic Rat Model for Colorectal Cancer

Baek JH, Agarwal ML, Tubbs RR, Vladisavljevic A, Tomita H, Bukowski R, Milsom JW, Kim JM, Kwak JY

The p53 gene has a significant role in controlling genomic stability of cancer. The purpose of this study was to evaluate the tumor response of allograft colorectal tumor treated with...
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Genetic screening in young women diagnosed with endometrial cancer

Pecorino B, Rubino C, Guardalà FVF, Galia A, Scollo P

OBJECTIVE: To evaluate the importance of Lynch syndrome associated risk screening in the patients aged less than 50 years affected from endometrial cancer. METHODS: From 2007 to 2014, 41 patients affected...
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