- Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study
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Kim YS, Shin JH, Bae MK, Lee CY, Kim DJ, Chung KY, Lee JG
- KMID: 2070194
- Yonsei Med J.
- 2014 Nov;55(6):1484-1488.
- doi: 10.3349/ymj.2014.55.6.1484
PURPOSE: Autophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence... -
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- Expression and Localization of COMMD1 Proteins in Human Placentas from Women with Preeclampsia
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Kwon HS, Park SH, Hwang HS, Sohn IS, Kim SN
- KMID: 1503916
- Yonsei Med J.
- 2013 Mar;54(2):494-499.
- doi: 10.3349/ymj.2013.54.2.494
PURPOSE: Recently, COMMD1 has been identified as a novel interactor and regulator of hypoxia-inducible factor-1 and nuclear factor kappa B transcriptional activity. The goal of this study was to determine... -
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- Pathogenesis and Management of Serrated Polyps: Current Status and Future Directions
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Anderson J
- KMID: 2070073
- Gut Liver.
- 2014 Nov;8(6):582-589.
- doi: 10.5009/gnl14248
Hyperplastic or serrated polyps were once believed to have little to no clinical significance. A subset of these polyps are now considered to be precursors to colorectal cancers (CRC) in... -
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- Three New Single Nucleotide Polymorphisms Identified by a Genome-Wide Association Study in Korean Patients with Vitiligo
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Cheong KA, Kim NH, Noh M, Lee AY
- KMID: 1777568
- J Korean Med Sci.
- 2013 May;28(5):775-779.
- doi: 10.3346/jkms.2013.28.5.775
Genetic susceptibility is involved in the pathogenesis of vitiligo. Association studies with a whole genome-based approach instead of a single or a few candidate genes may be useful for discovering... -
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- Candidates for Tumor Markers of Cervical Cancer Discovered by Proteomic Analysis
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Song JY, Bae HS, Koo DH, Lee JK, Jung HH, Lee KW, Lee NW
- KMID: 2157970
- J Korean Med Sci.
- 2012 Dec;27(12):1479-1485.
- doi: 10.3346/jkms.2012.27.12.1479
Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study... -
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- Functional proteomics, human genetics and cancer biology of GIPC family members
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Katoh M
- KMID: 2154245
- Exp Mol Med.
- 2013 Jun;45(6):e26.
GIPC1, GIPC2 and GIPC3 consist of GIPC homology 1 (GH1) domain, PDZ domain and GH2 domain. The regions around the GH1 and GH2 domains of GIPC1 are involved in dimerization... -
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- Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells
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Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K
- KMID: 2155390
- Exp Mol Med.
- 2014 Dec;46(12):e125.
- doi: 10.1038/emm.2014.77
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have... -
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- The adaptor protein LAD/TSAd mediates laminin-dependent T cell migration via association with the 67 kDa laminin binding protein
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Park E, Choi Y, Ahn E, Park I, Yun Y
- KMID: 1009394
- Exp Mol Med.
- 2009 Oct;41(10):728-736.
- doi: 10.3858/emm.2009.41.10.079
The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further understand the functions of this protein, we performed yeast two-hybrid screening using TSAd as bait and identified... -
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- DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers
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Kato M, Takano M, Miyamoto M, Sasaki N, Goto T, Tsuda H, Furuya K
- KMID: 2158801
- J Gynecol Oncol.
- 2015 Jan;26(1):40-45.
- doi: 10.3802/jgo.2015.26.1.40
OBJECTIVE: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not... -
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- Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity
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Song M, Kim MJ, Ha S, Park JB, Ryu SH, Suh PG
- KMID: 1056227
- Exp Mol Med.
- 2005 Jun;37(3):161-168.
Phospholipase C-gamma1, containing two SH2 and one SH3 domains which participate in the interaction between signaling molecules, plays a significant role in the growth factor-induced signal transduction. However, the role... -
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- Emodin prevents intima thickness via Wnt4/Dvl-1/beta-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats
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Hua JY, He YZ, Xu Y, Jiang XH, Ye W, Pan ZM
- KMID: 2155424
- Exp Mol Med.
- 2015 Jun;47(6):e170.
- doi: 10.1038/emm.2015.36
Neointimal proliferation after vascular injury is a key mechanism of restenosis, a major cause of percutaneous transluminal angioplasty failure and artery bypass occlusion. Emodin, an anthraquinone with multiple physiological activities,... -
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- Shank 2 expression coincides with neuronal differentiation in the developing retina
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Kim JH, Kim JH, Yang E, Park JH, Yu YS, Kim KW
- KMID: 1088598
- Exp Mol Med.
- 2009 Apr;41(4):236-242.
- doi: 10.3858/emm.2009.41.4.026
The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation... -
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- Toll-like receptor signal transduction
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Krishnan J, Selvarajoo K, Tsuchiya M, Lee G, Choi S
- KMID: 756065
- Exp Mol Med.
- 2007 Aug;39(4):421-438.
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing exogenous pathogens. Activation of TLRs is a first line of defense of the immune system, leading to the activation... -
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- Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled
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Jung H, Kim HJ, Lee SK, Kim R, Kopachik W, Han JK, Jho EH
- KMID: 1009391
- Exp Mol Med.
- 2009 Oct;41(10):695-706.
- doi: 10.3858/emm.2009.41.10.076
Wnt signaling is known to be important for diverse embryonic and post-natal cellular events and be regulated by the proteins Dishevelled and Axin. Although Dishevelled is activated by Wnt and... -
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- Is Immunohistochemistry for MLH1 and MSH2 Proteins a Useful Method for Detection of Microsatellite Instability in Sporadic Colorectal Cancer?
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Do JH, Chang SK, Ahnn JY, Cha BK, Cheong SM, Kim DW, Cheong HR, Kim HJ, Kim JG, Lee TJ, Park ES, Park SM
- KMID: 1112187
- Korean J Gastroenterol.
- 2003 Nov;42(5):369-376.
BACKGROUND/AIMS: In order to identify microsatellite instability (MSI), the test based on the polymerase chain reaction (PCR) can be used. However, PCR is not routinely performed in all hospital... -
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- Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65
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Lee EJ, Hyun S, Chun J, Shin SH, Kang SS
- KMID: 1119321
- Exp Mol Med.
- 2009 Aug;41(8):555-568.
- doi: 10.3858/emm.2009.41.8.061
Fe65 has been characterized as an adaptor protein, originally identified as an expressed sequence tag (EST) corresponding to an mRNA expressed at high levels in the rat brain. It contains... -
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- Clinicopathological Characteristics of Colorectal Cancer with Family History: an Evaluation of Family History as a Predictive Factor for Microsatellite Instability
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Park IJ, Kim HC, Yoon YS, Yu CS, Jang SJ, Kim JC
- KMID: 1785795
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S91-S97.
- doi: 10.3346/jkms.2007.22.S.S91
To determine whether family history of cancer may be a risk factor for the mutator phenotype in colorectal cancer, we recruited 143 consecutive colorectal cancer patients with a family history... -
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- Time-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines
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Kim KH, Yoo HY, Joo KM, Jung Y, Jin J, Kim Y, Yoon SJ, Choi SH, Seol HJ, Park WY, Nam DH
- KMID: 1015461
- Exp Mol Med.
- 2011 Jul;43(7):419-426.
- doi: 10.3858/emm.2011.43.7.046
Radiation is the most useful treatment modality for cancer patients. It initiates a series of signal cascades such as DNA damage response (DDR) signaling for repairing damaged DNA, arresting the... -
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- Mutation analysis of p31(comet) gene, a negative regulator of Mad2, in human hepatocellular carcinoma
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Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH
- KMID: 756074
- Exp Mol Med.
- 2007 Aug;39(4):508-513.
Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment... -
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- Methylation Pattern of DNA Repair Genes and Microsatellite Instability in Hepatocelluar Carcinoma
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Park JH, Cho SB, Lee WS, Park CH, Joo YE, Kim HS, Choi SK, Rew JS, Lee JH, Kim SJ
- KMID: 1113480
- Korean J Gastroenterol.
- 2006 Nov;48(5):327-336.
BACKGROUND/AIMS: Epigenetic silencing of DNA repair genes, O6-methylguanine-DNA methyltransferase (MGMT), hMLH1 and hMSH3, by promoter hypermethylation have been observed in various cancers. However, the relationship between hypermethylation of DNA... -
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