- Regulation of Cartilage Development and Diseases by Transcription Factors
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Nishimura , Hata K, Takahata Y, Murakami T, Nakamura E, Yagi H
- KMID: 2415952
- J Bone Metab.
- 2017 Aug;24(3):147-153.
- doi: 10.11005/jbm.2017.24.3.147
Genetic studies and molecular cloning approaches have been successfully used to identify several transcription factors that regulate the numerous stages of cartilage development. Sex-determining region Y (SRY)-box 9 (Sox9) is... -
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- Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress
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Kim B, Kim J, Kim YS
- KMID: 2399898
- Anat Cell Biol.
- 2017 Dec;50(4):293-300.
- doi: 10.5115/acb.2017.50.4.293
Cyclooxygenase-2 (COX-2) is an enzyme induced by various proinflammatory and mitogenic stimuli. Celecoxib is a selective inhibitor of COX-2 that have been shown to affect cell growth and apoptosis. Lung... -
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- 4-phenylbutyric Acid Regulates Collagen Synthesis and Secretion Induced by High Concentrations of Glucose in Human Gingival Fibroblasts
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Lee GH, Oh HW, Lim HD, Lee W, Chae HJ, Kim HR
- KMID: 2285421
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):345-351.
- doi: 10.4196/kjpp.2011.15.6.345
High glucose leads to physio/pathological alterations in diabetes patients. We investigated collagen production in human gingival cells that were cultured in high concentrations of glucose. Collagen synthesis and secretion were... -
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- Guanabenz Acetate Induces Endoplasmic Reticulum Stress–Related Cell Death in Hepatocellular Carcinoma Cells
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Kang HJ, Seol HS, Lee SE, Suh YA, Kim J, Jang SJ, Yu E
- KMID: 2465448
- J Pathol Transl Med.
- 2019 Mar;53(2):94-103.
- doi: 10.4132/jptm.2019.01.14
BACKGROUND: Development of chemotherapeutics for the treatment of advanced hepatocellular carcinoma (HCC) has been lagging. Screening of candidate therapeutic agents by using patient-derived preclinical models may facilitate drug discovery for... -
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- Remote Ischemic Preconditioning Enhances the Expression of Genes Encoding Antioxidant Enzymes and Endoplasmic Reticulum Stress-Related Proteins in Rat Skeletal Muscle
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Park UJ, Kim HT, Cho WH, Park JH, Jung HR, Kim MY
- KMID: 2364675
- Vasc Spec Int.
- 2016 Dec;32(4):141-149.
- doi: 10.5758/vsi.2016.32.4.141
PURPOSE: Ischemic preconditioning (IPC), including remote IPC (rIPC) and direct IPC (dIPC), is a promising method to decrease ischemia-reperfusion (IR) injury. This study tested the effect of both rIPC and... -
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- rBMSCs/ITGA5B1 Promotes Human Vascular Smooth Muscle Cell Differentiation via Enhancing Nitric Oxide Production
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Zhang Y, Ding J, Xu C, Yang H, Xia P, Ma S, Chen H
- KMID: 2429549
- Int J Stem Cells.
- 2018 Nov;11(2):168-176.
- doi: 10.15283/ijsc18079
BACKGROUND AND OBJECTIVES: Previous studies have shown that integrins alpha5beta1 (ITGA5B1) gene-modified rat bone marrow mesenchymal stem cells (rBMSCs) could prevent cell anoikis and increase the nitric oxide (NO) production.... -
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- Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells
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Cho YM, Jang YS, Jang YM, Chung SM, Kim HS, Lee JH, Jeong SW, Kim IK, Kim JJ, Kim KS, Kwon OJ
- KMID: 756236
- Exp Mol Med.
- 2009 Jun;41(6):440-452.
- doi: 10.3858/emm.2009.41.6.049
When we treated rat bone marrow stromal cells (rBMSCs) with neuronal differentiation induction media, typical unfolded protein response (UPR) was observed. BIP/GRP78 protein expression was time-dependently increased, and three branches... -
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