- Effect of Pitavastatin Treatment on ApoB-48 and Lp-PLA2 in Patients with Metabolic Syndrome: Substudy of PROspective Comparative Clinical Study Evaluating the Efficacy and Safety of PITavastatin in Patients with Metabolic Syndrome
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Lee HS, Jung CH, Kim SR, Jang HC, Park CY, PROPIT Study Team
- KMID: 2169702
- Endocrinol Metab.
- 2016 Mar;31(1):120-126.
- doi: 10.3803/EnM.2016.31.1.120
BACKGROUND: Apolipoprotein (Apo) B-48 is an intestinally derived lipoprotein that is expected to be a marker for cardiovascular disease (CVD). Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a vascular-specific inflammatory marker and... -
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- Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis
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Zhang J, Xu DL, Liu XB, Bi SJ, Zhao T, Sui SJ, Ji XP, Lu QH
- KMID: 2374035
- Yonsei Med J.
- 2016 Mar;57(2):321-327.
- doi: 10.3349/ymj.2016.57.2.321
PURPOSE: Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and Rho kinase activity may be associated with atherosclerosis. The principal aim of this study was to examine whether darapladib (a selective Lp-PLA2... -
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- Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
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Chung H, Kwon HM, Kim JY, Yoon YW, Rhee J, Choi EY, Min PK, Hong BK, Rim SJ, Yoon JH, Lee SJ, Park JK, Kim MH, Jo M, Yang JH, Lee BK
- KMID: 2070197
- Yonsei Med J.
- 2014 Nov;55(6):1507-1515.
- doi: 10.3349/ymj.2014.55.6.1507
PURPOSE: Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) binds to low-density lipoprotein. The levels of Lp-PLA2 reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic... -
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- Multimarker Approach in Discriminating Patients with Symptomatic and Asymptomatic Atherosclerotic Carotid Artery Stenosis
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Musialek P, Tracz W, Tekieli L, Pieniazek , Kablak-Ziembicka A, Przewlocki T, Stepien E, Kapusta P, Motyl R, Stepniewski J, Undas A, Podolec P
- KMID: 2287555
- J Clin Neurol.
- 2013 Jul;9(3):165-175.
- doi: 10.3988/jcn.2013.9.3.165
BACKGROUND AND PURPOSE: Several circulating biomarkers have been implicated in carotid atherosclerotic plaque rupture and thrombosis; however, their clinical utility remains unknown. The aim of this study was to determine... -
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- Taiwanese Female Vegetarians Have Lower Lipoprotein-Associated Phospholipase A2 Compared with Omnivores
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Chen CW, Lin CT, Lin YL, Lin TK, Lin CL
- KMID: 1106431
- Yonsei Med J.
- 2011 Jan;52(1):13-19.
- doi: 10.3349/ymj.2011.52.1.13
PURPOSE: Many studies supported that vegetarians have a lower risk of cardiac diseases and mortality, partly due to better blood pressure and serum cholesterol profiles. However, the inflammatory markers, especially... -
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- Association of Lipoprotein-Associated Phospholipase A2 with Characteristics of Vulnerable Coronary Atherosclerotic Plaques
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Liu YS, Hu XB, Li HZ, Jiang WD, Wang X, Lin H, Qin AQ, Wang YM, Zhao T, Dong ZQ, Zhang M, Lu QH
- KMID: 1058810
- Yonsei Med J.
- 2011 Nov;52(6):914-922.
- doi: 10.3349/ymj.2011.52.6.914
PURPOSE: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory enzyme expressed in atherosclerotic plaques. We investigated the association of circulating Lp-PLA2 with characteristics of vulnerable coronary atherosclerotic plaques. MATERIALS AND METHODS: We... -
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