- Islet Transplantation and Regeneration for Treatment of Diabetes
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Yamada Y
- KMID: 1726146
- Yonsei Med J.
- 2004 Jun;45(Suppl):S53-S55.
- doi: 10.3349/ymj.2004.45.Suppl.53
Islet transplantation has the potential to restore normoglycemia and prevent the development of diabetic complications such as retinopathy, nephropathy and neuropathy, and could therefore ve a valuable treatment for diabetic... -
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- Transplantation of betacellulin-transduced islets improves glucose intolerance in diabetic mice
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Song MY, Bae UJ, Jang KY, Park BH
- KMID: 2155363
- Exp Mol Med.
- 2014 May;46(5):e98.
- doi: 10.1038/emm.2014.24
Type 1 diabetes is an autoimmune disease caused by permanent destruction of insulin-producing pancreatic beta cells and requires lifelong exogenous insulin therapy. Recently, islet transplantation has been developed, and although... -
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- Effect of nicotinamide on early graft failure following intraportal islet transplantation
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Jung DY, Park JB, Joo SY, Joh JW, Kwon CH, Kwon GY, Kim SJ
- KMID: 1122279
- Exp Mol Med.
- 2009 Nov;41(11):782-792.
- doi: 10.3858/emm.2009.41.11.084
Intraportal islet transplantation (IPIT) may potentially cure Type 1 diabetes mellitus; however, graft failure in the early post-transplantation period presents a major obstacle. In this study, we tested the ability... -
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- Comparison of Four Pancreatic Islet Implantation Sites
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Kim HI, Yu JE, Park CG, Kim SJ
- KMID: 1779248
- J Korean Med Sci.
- 2010 Feb;25(2):203-210.
- doi: 10.3346/jkms.2010.25.2.203
Although the liver is the most common site for pancreatic islet transplantation, it is not optimal. We compared kidney, liver, muscle, and omentum as transplantation sites with regard to operative... -
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- Evaluation of Porcine Pancreatic Islets Transplanted in the Kidney Capsules of Diabetic Mice Using a Clinically Approved Superparamagnetic Iron Oxide (SPIO) and a 1.5T MR Scanner
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Kim HS, Kim H, Park KS, Moon WK
- KMID: 1119231
- Korean J Radiol.
- 2010 Dec;11(6):673-682.
- doi: 10.3348/kjr.2010.11.6.673
OBJECTIVE: To evaluate transplanted porcine pancreatic islets in the kidney capsules of diabetic mice using a clinically approved superparamagnetic iron oxide (SPIO) and a 1.5T MR scanner. MATERIALS AND METHODS:... -
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- Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGF-transfected islets in streptozotocin-induced diabetic mice
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Chae HY, Lee BW, Oh SH, Ahn YR, Chung JH, Min YK, Lee MS, Lee MK, Kim KW
- KMID: 1116196
- Exp Mol Med.
- 2005 Dec;37(6):513-523.
Hypoxic damage is one of the major causes of islet graft failure and VEGF is known to play a crucial role in revascularization. To address the effectiveness of a cationic... -
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- Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation
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Zhu H, Wang J, Jiang H, Ma Y, Pan S, Reddy S, Sun X
- KMID: 994397
- Exp Mol Med.
- 2010 Nov;42(11):739-748.
- doi: 10.3858/emm.2010.42.11.075
Nonspecific inflammatory response is the major cause for failure of islet grafts at the early phase of intraportal islet transplantation (IPIT). Bilirubin, a natural product of heme catabolism, has displayed... -
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- Prolonged survival of islet allografts in mice treated with rosmarinic acid and anti-CD154 antibody
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Jung DY, Kim EY, Joo SY, Park JB, Moon C, Kim SH, Sim EY, Joh JW, Kwon CH, Kwon GY, Kim SJ
- KMID: 1103582
- Exp Mol Med.
- 2008 Feb;40(1):1-10.
- doi: 10.3858/emm.2008.40.1.1
Pancreatic islet transplantation can correct the abnormal glucose metabolism of Type 1 diabetes. Although immunosuppressants greatly reduce the acute rejection rate in transplant patients, the long-term side effects can be... -
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- Increase in Anti-Gal IgM Level is Associated With Early Graft Failure in Intraportal Porcine Islet Xenotransplantation
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Kang HJ, Lee H, Park EM, Kim JM, Shin JS, Kim JS, Park CG, Kim SJ
- KMID: 2363264
- Ann Lab Med.
- 2015 Nov;35(6):611-617.
- doi: 10.3343/alm.2015.35.6.611
BACKGROUND: Anti-Gal is a major antibody induced in non-human primates (NHPs) after xenotransplantation. To understand the mechanism of graft rejection, we investigated the association between anti-Gal responses and graft failure... -
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- Differentiation of human labia minora dermis-derived fibroblasts into insulin-producing cells
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Kim B, Yoon BS, Moon JH, Kim J, Jun EK, Lee JH, Kim JS, Baik CS, Kim A, Whang KY, You S
- KMID: 1120139
- Exp Mol Med.
- 2012 Jan;44(1):26-35.
- doi: 10.3858/emm.2012.44.1.002
Recent evidence has suggested that human skin fibroblasts may represent a novel source of therapeutic stem cells. In this study, we report a 3-stage method to induce the differentiation of... -
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