Yonsei Med J.  2004 Jun;45(Suppl):S53-S55. 10.3349/ymj.2004.45.Suppl.53.

Islet Transplantation and Regeneration for Treatment of Diabetes

• Yamada Y

• KMID: 1726146
• DOI: http://doi.org/10.3349/ymj.2004.45.Suppl.53

Abstract

Islet transplantation has the potential to restore normoglycemia and prevent the development of diabetic complications such as retinopathy, nephropathy and neuropathy, and could therefore ve a valuable treatment for diabetic patients. The scarcity of available islets is an obstacle for clinically successful islet transplantation. To resolve the problems, we have examined the two methods, islet transplantation with extracellular matrix1 and in vivo expansion of islets with electrically- transfection of growth factors.

Keyword

Insulin; islets; fibronectin; HGF

MeSH Terms

Animals
Diabetes Mellitus/surgery/*therapy
Fibronectins/therapeutic use
Hepatocyte Growth Factor/genetics
Islets of Langerhans/drug effects/*physiopathology
*Islets of Langerhans Transplantation
Male
Rats
Rats, Wistar
*Regeneration
Transfection