The Study of Clinical Characteristic Changes in Acute Poststreptococcal Glomerulonephtritis: Comparision of Clinical Manifestations between Recent 5 Years and Past 5 Years

Yoon, Hye Won; Park, Kyung Soo; Lee, Jae Ho

Abstract

PURPOSE
The purpose of this study is to evaluate the clinical characteristic changes of acute poststeptococcal glomerulonephritis (APSGN) in recent. The cases of APSGN occurred for the last ten years were divided into group I and II by the unit of 5 years and clinical manifestations and laboratory findings of each groups were analyzed. METHODS: Total of 74 cases of APSGN, diagnosed at the department of Pediatrics, Chungnam National University Hospital from January 1995 to August 2004 were divided into group I (31 cases from January 1995 to December 1999) & II (43 cases from January 2000 to August 2004). In addition, the clinical records of each group were reviewed retrospectively and compared. RESULTS: In both groups, the prevalence rate was much higher in males than females, the seasonal prevalence rate was higher in winter, the upper respiratory infection was most frequent predisposing illness, and one to two weeks of latent period was the highest. However, the average age for group II were younger than group I. The prevalence rate of gross hematuria was higher in group II, but there was no significant difference between two groups. In the course of clinical symptoms, edema and hypertension were relieved within two weeks in both groups. In group II, the prevalence rate of proteinuria was higher, and the duration of proteinuria and gross hematuria were longer than group I. CONCLUSION: In this comparative study, the average age became younger. Clinically the duration of gross hematuria and proteinuria became longer, and the prevalence rate of proteinuria increased in recent 5 years. However, there was no difference between two groups in clinical courses and prognosis.