J Korean Soc Pediatr Nephrol.  2000 Dec;4(2):154-160.

Two Cases of Acute Poststreptococcal Glomerulonephritis Superimposing to IgA Nephropathy

• Kim YK
• Lee JH
• Hahn H
• Ha IS
• Cheong HI
• Choi Y

Abstract

The pathogenesis of IgA nephropathy and acute poststreptococcal glomerulonephritis is not fully understood. In the past, acute poststreptococcal glomerulonephritis was the most common cause of gross hematuria in children, but now IgA nephropathy is the most common one. We experienced two cases of acute poststreptococcal glomerulonephritis superimposing to IgA nephropathy in boys. Case 1 had upper respiratory infection before elevation of anti-streptolysin O, generalized edema, gross hematuria and proteinuria. The complement levels were normal. Electron microscopic findings of renal biopsy at ten days after onset showed a few big subepithelial 'humps' and localized heavy subendothelial and mesangial deposits. Immunofluoroscopic findings revealed predominant IgA deposition in the mesangium. The electron microscopic findings were diagnostic of acute poststreptococcal glomerulonephritis. On the other hand, immunoflorescence microscopic findings were compatible to IgA nephropathy. In case 2, the renal biopsy which was done 2 years after onset showed only finding of IgA nephropathy. To our knowledges, there has been few reports of acute poststreptococcal glomerulonephritis superimposing to IgA nephropathy which was confirmed by renal biopsy. We report two cases of acute poststreptococcal glomerulonephritis superimposing to IgA nephropathy with a brief review of the literatures.

Keyword

Acute poststreptococcal glomerulonephritis; IgA Nephropathy; Superimposing

MeSH Terms

Biopsy
Child
Complement System Proteins
Edema
Glomerulonephritis*
Glomerulonephritis, IGA*
Hand
Hematuria
Humans
Immunoglobulin A*
Proteinuria
Complement System Proteins
Immunoglobulin A