J Prev Med Public Health.  2005 Nov;38(4):431-436.

Seroprevalence of Measles Antibody and its Attributable Factors in Elementary Students of Routine 2-dose Schedule Era with Vaccination Record

• Bae GR
• Lim HS
• Goh UY
• Yang BG
• Kim YT
• Lee JK

Abstract

OBJECTIVES
We investigated the seroprevalence of the measles antibody and its attributable factors for the students who underwent routine 2-dose Schedule Era. METHODS: The subjects were 996 students of the national measles seroepidemiologic study in December 2000 who had vaccination records. We conducted a questionnaire survey and we performed serologic testing for the measles specific IgG by using an enzyme linked immunosorbent assay. RESULTS: The coverage for the first dose of the MMR vaccination at 12-15 months of age was 95.1% and the coverage for the second dose of MMR at 4-6 years of age was 35.0%. The proportion of subjects undergoing 2- doses of MMR decreased as the age of the subjects increased. The seropositive rate of the measles antibody was significantly high in the second dose vaccinees (93.5% in the second dose group, 84.7% in the non-second dose group, p< 0.001) and it was 72.0% in the 0-dose group, 85.4% in the 1-dose group and 93.7% in the 2-dose group (p< 0.001). Two point eight percent of the subjects had a past history of measles infection. On the multiple logistic regression analysis, the first and second dose (odds ratio, 8.54; 95% CI.=3.05-23.91), the first dose (odds ratio, 3.06; 95% CI.=1.20-7.81) and the outbreak in the year 2000 (odds ratio, 1.89; 95% CI.=1.24-2.88) were the significant factors for the eropositivity. CONCLUSIONS: Maintaining high coverage with a 2-dose vaccination program would be the decisive factor to prevent an outbreak of measles and to eliminate measles in Korea.

Keyword

Measles; MMR vaccine; Vaccination; Seroprevalence

MeSH Terms

Antibodies, Viral/*blood
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Health Surveys
Humans
Immunization Programs/*utilization
Immunization Schedule
Immunoglobulin G/blood
Infant
Korea
Male
Measles/immunology/*prevention & control
Measles virus/*immunology
Measles-Mumps-Rubella Vaccine/administration & dosage/*immunology
Questionnaires
Schools
Seroepidemiologic Studies
*Students