Korean J Gastroenterol.  2008 Nov;52(5):286-292.

The Change of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in the Gastric Mucosa One Year after Eradication of Helicobacter pylori

• Kim SS
• Sung YJ
• Park MK
• Lim CH
• Yang HJ
• Kim TH
• Kim CW
• Kim JI
• Han SW
• Chung IS

Abstract

BACKGROUND/AIMS: The cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), the proteins that have the role in the gastric carcinogenesis, are stimulated by H. pylori infection in the gastric mucosa. The aim of this study was to evaluate the expression of COX-2 and iNOS proteins one year after the eradication of H. pylori.
METHODS
Gastric antral mucosa from fifty eight patients with chronic gastritis who were all infected with H. pylori was examined for the expression of COX-2 and iNOS proteins before and one year after the eradication of H. pylori by immunohistochemical stain.
RESULTS
COX-2 and iNOS proteins were expressed in the epithelial cells and interstitial inflammatory cells of gastric mucosa. Percent expressions of COX-2 and iNOS were significantly decreased one year after the eradication in the patients with cured infection, but not in those having persistent H. pylori. COX-2 and iNOS expressions were well correlated with H. pylori density, acute and chronic inflammation of gastric mucosa.
CONCLUSIONS
The eradication of H. pylori can decrease the expression of COX-2 and iNOS in the gastric mucosa in long-term period. This seems to be due to the removal of H. pylori itself and related regression of gastric inflammation.

Keyword

Helicobacter pylori, eradication; Cyclooxygenase-2; Inducible nitric oxide synthase

MeSH Terms

Cyclooxygenase 2/immunology/*metabolism
Drug Therapy, Combination
Gastric Mucosa/*enzymology
Helicobacter Infections/drug therapy
*Helicobacter pylori
Humans
Nitric Oxide Synthase Type II/immunology/*metabolism
Time Factors