Korean J Gastroenterol.  2008 Jan;51(1):11-18.

Role of Anti-secretory Treatment in Addition to Helicobacter pylori Eradication Triple Therapy in the Treatment of Peptic Ulcer

• Jung JM
• Shim KN
• Oh HJ
• Na YJ
• Jung HS
• Jung SA
• Yoo K

Abstract

BACKGROUND/AIMS
It is not clear whether the anti-secretory therapy should be continued for symptomatic relief and ulcer healing before or after the eradication of H. pylori in patients with peptic ulcer disease. The aim of this study was to evaluate the effectiveness of additional anti-secretory therapy before or after H. pylori eradication in peptic ulcer disease.
METHODS
Thirty eight patients with H. pylori-positive active peptic ulcer were included. Patients were randomly allocated into 3 groups; standard 1-week triple therapy followed by omeprazole (20 mg, qd) for 3 weeks (group A), standard 1-week triple therapy only (group B), and omeprazole (20 mg, qd) for 3 weeks followed by 1-week triple therapy (group C). Endoscopy with the rapid urease test and histology for H. pylori was performed 4-8 weeks after the completion of treatment. The symptom was scored by a visual analog scale.
RESULTS
Of the 38 patients, 10 were excluded from the per-protocol analysis of this study. The H. pylori eradication rates were 87.5% (group A), 80.0% (group B) and 90.0% (group C) respectively. The peptic ulcer healing rates were 100% in group A, 70.0% in group B, and 90.0% in group C. There was no difference in H. pylori eradication rates and ulcer healing rates among three groups (p>0.05). Symptom score differences between pre-treatment and post-treatment group were not significantly different (p>0.05).
CONCLUSIONS
The standard one week triple therapy with or without 3-weeks anti-secretory treatment with omeprazole before or after the therapy does not affect H. pylori eradication rates, peptic ulcer healing rates, and symptom score improvement.

Keyword

Proton pump inhibitor; Helicobacter pylori; Eradication; Peptic ulcer

MeSH Terms

Adult
Anti-Bacterial Agents/administration & dosage/therapeutic use
Anti-Ulcer Agents/administration & dosage/*therapeutic use
Drug Therapy, Combination
Female
Helicobacter Infections/*drug therapy
*Helicobacter pylori
Humans
Male
Middle Aged
Omeprazole/administration & dosage/therapeutic use
Peptic Ulcer/*drug therapy/microbiology