Efficacy of 1-week Pantoprazole-Based Triple Therapy in Eradicating Helicobacter pylori without Additional Acid Suppression Therapy

Choi, Il Ju; Lee, Woo Jin; Kim, You Sun; Kim, Joo Sung; Jung, Hyun Chae; Song, In Sung; Kim, Chung Yong

Abstract

BACKGROUND/AIMS: Proton pump inhibitor (PPI)-based triple therapy is effective for Helicobacter pylori (H. pylori) eradication. However, there are some controversies on the duration of the therapy and on the necessity of the acid suppression therapy for ulcer healing after eradication. We evaluated the efficacy and safety of one-week pantoprazole-based triple therapy for H. pylori eradication and ulcer healing.
METHODS
Forty-two patients with H. pylori-positive peptic ulcer received PAC regimen (pantoprazole 40 mg b.i.d., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d.) for one week without further acid suppression therapy. H. pylori infection was assessed before and 4 weeks after the completion of treatment by CLO test and histopathology and the ulcers were also evaluated.
RESULTS
H. pylori eradication rates were 88.1% by intention-to-treat (ITT) analysis and 90% by per-protocol (PP) analysis. Ulcer was completely healed in 90.9% by ITT analysis and in 95.2% by PP analysis. Ulcer symptoms were significantly improved at the end of treatment. There was no serious side effect despite mild adverse events in 31% of the patients.
CONCLUSIONS
One-week pantoprazole-based triple therapy is an effective and safe regimen for H. pylori eradication in patients with peptic ulcer. The regimen is efficacious for healing ulcer and resolving symptoms without further acid suppression therapy.