Korean J Gastroenterol.
2006 Aug;48(2):67-74.
Adipocyte Signals in Energy Balance and Digestive Diseases
- Affiliations
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- 1Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea. kumcge@chol.com
- 2Department of Institute of Human Genetics, Korea University College of Medicine, Seoul, Korea
Abstract
- For the regulation of energy balance in various internal organs including gut, pancreas and liver, visceral adipose tissue and brain perform important sensing and signaling roles via neural and endocrine pathway. Among these, adipose tissue has been known as a simple energy-storing organ, which stores excess energy in triglyceride. However, it became apparent that adipocytes have various receptors related to energy homeostasis, and secrete adipocytokines by endocrine, paracrine and autocrine mechanisms. In this review, basic roles of adipocytes in energy homeostasis and the correlation between adipocyte signals and digestive diseases are discussed.
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