Korean J Gastroenterol.  2004 Feb;43(2):96-103.

Comparison of Midazolam versus Midazolam/Meperidine during Colonoscopy in a Prospective, Randomized, Double-Blind Study

• Jung HK
• Bae KS
• Yoon SJ
• Lee JS
• Kwon JM
• Yoo MA

Abstract

BACKGROUND/AIMS: Colonoscopy is a painful procedure. Therefore conscious sedation is often used. However, the value of adding analgesics to sedatives has not been well evaluated. METHODS: The double blind, randomized controlled trial was carried out to compare patients' and endoscopist' assessments in both groups of patients: MP (Midazolam/Placebo) group (n=49) received midazolam plus placebo and MM (Midazolam/Meperidine) group (n=51) received midazolam plus meperidine. RESULTS: There was no significant difference of baseline characteristics except previous operation history. There were no significant difference of grade of tolerance, pain and willingness to another colonoscopy between the two groups. In endoscopist' satisfaction, the degree of difficulty was higher in MP group than in MM group (39.0 vs. 31.7,p<0.05). After the colonoscopy, systolic blood pressure, oxygen saturation, and pulse rate were significantly decreased (p<0.05) in both groups. However, there was no difference in the degree of decrease between the two groups. The incidence of adverse effect was not different in the two groups. However, one case of orthostatic hypotension with presyncope was noted in MM group. CONCLUSIONS: Adding meperidine to the midazolam before the colonoscopy does not seem to bring more beneficial effect to patients, whereas endoscopist favored the use of both medications.

Keyword

Colonoscopy; Midazolam; Meperidine

MeSH Terms

Adult
Aged
Analgesics, Opioid/*administration & dosage/adverse effects
*Colonoscopy
Comparative Study
Double-Blind Method
English Abstract
Female
Humans
Hypnotics and Sedatives/*administration & dosage/adverse effects
Male
Meperidine/*administration & dosage/adverse effects
Midazolam/*administration & dosage/adverse effects
Middle Aged